AutismKB 2.0

Annotation Detail for TIAL1


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Basic Information Top
Gene Symbol:TIAL1 ( MGC33401,TCBP,TIAR )
Gene Full Name: TIA1 cytotoxic granule-associated RNA binding protein-like 1
Band: 10q26.11
Quick LinksEntrez ID:7073; OMIM: 603413; Uniprot ID:TIAR_HUMAN; ENSEMBL ID: ENSG00000151923; HGNC ID: 11804
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst9 / 62319144
fetus34 / 56401260
neonate0 / 310970 
infant0 / 236200 
juvenile9 / 55556161
adult186 / 193912195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor1 / 3436629
chondrosarcoma13 / 82823156
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor34 / 119369284
germ cell tumor18 / 26384568
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor6 / 6895987
leukemia14 / 95842146
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma8 / 71755111
non-neoplasia9 / 9725092
normal216 / 336030764
ovarian tumor12 / 76682156
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland2 / 3319760
ascites4 / 4001599
bladder1 / 2975733
blood18 / 123478145
bone11 / 71655153
bone marrow1 / 4880120
brain44 / 110098939
cervix3 / 4817162
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue25 / 215722115
esophagus0 / 202090 
eye9 / 21105442
heart11 / 89626122
intestine17 / 23447272
kidney24 / 211777113
larynx4 / 24145165
liver15 / 20774372
lung30 / 33697489
lymph3 / 4427067
lymph node13 / 91610141
mammary gland15 / 15327197
mouth1 / 6705214
muscle12 / 107715111
nerve1 / 1576863
ovary13 / 102051127
pancreas17 / 21481279
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta15 / 28082553
prostate2 / 18934510
salivary gland3 / 20155148
skin4 / 21057418
spleen3 / 5395255
stomach30 / 96619310
testis18 / 33044254
thymus9 / 81131110
thyroid3 / 4747363
tonsil2 / 16999117
trachea3 / 5241357
umbilical cord0 / 136800 
uterus27 / 232878115
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202406_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1169.1
Adipocyte85.05
AdrenalCortex51.85
Adrenalgland42.4
Amygdala62.25
Appendix44.55
AtrioventricularNode37.7
BDCA4+_DentriticCells761.35
Bonemarrow62.5
BronchialEpithelialCells259.35
CD105+_Endothelial631.3
CD14+_Monocytes390.05
CD19+_BCells(neg._sel.)902.05
CD33+_Myeloid1121.7
CD34+1015.7
CD4+_Tcells962.35
CD56+_NKCells1143.65
CD71+_EarlyErythroid638
CD8+_Tcells1012.3
CardiacMyocytes183.5
Caudatenucleus42.75
Cerebellum24.2
CerebellumPeduncles34.1
CiliaryGanglion13.6
CingulateCortex60.7
Colorectaladenocarcinoma202.1
DorsalRootGanglion29
FetalThyroid123.75
Fetalbrain109.7
Fetalliver48.4
Fetallung231.35
GlobusPallidus16.85
Heart48.25
Hypothalamus114.5
Kidney31.1
Leukemia_chronicMyelogenousK-562376.5
Leukemia_promyelocytic-HL-60497.15
Leukemialymphoblastic(MOLT-4)612.3
Liver62.65
Lung52.55
Lymphnode332.75
Lymphoma_burkitts(Daudi)739.2
Lymphoma_burkitts(Raji)697.7
MedullaOblongata37.95
OccipitalLobe54.1
OlfactoryBulb93.1
Ovary30.25
Pancreas146.65
PancreaticIslet199.45
ParietalLobe56.75
Pituitary97.4
Placenta179.4
Pons34.55
PrefrontalCortex90.55
Prostate98.65
Salivarygland176.3
SkeletalMuscle41.15
Skin24.65
SmoothMuscle196.3
Spinalcord105.6
SubthalamicNucleus30.6
SuperiorCervicalGanglion23.6
TemporalLobe20.7
Testis91.95
TestisGermCell156.8
TestisIntersitial99.45
TestisLeydigCell98.75
TestisSeminiferousTubule146.55
Thalamus61.65
Thymus172.35
Thyroid154.45
Tongue81.55
Tonsil235.45
Trachea76.7
TrigeminalGanglion24.15
Uterus141.4
UterusCorpus72.5
WholeBlood336.25
Wholebrain54.4
colon95
pineal_day136.52
pineal_night137.88
retina112.025
small_intestine90.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7505_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.28 ± 0.49
Basal Forebrain7.62 ± 0.22
Basal Part of Pons7.59 ± 0.25
Cerebellar Cortex7.85 ± 0.12
Cerebellar Nuclei7.71 ± 0.2
Claustrum7.17 ± 0.48
Epithalamus7.68 ± 0.23
Frontal Lobe7.55 ± 0.26
Globus Pallidus7.61 ± 0.27
Hypothalamus7.63 ± 0.13
Insula7.59 ± 0.12
Limbic Lobe7.48 ± 0.27
Mesencephalon7.52 ± 0.38
Myelencephalon7.52 ± 0.31
Occipital Lobe7.53 ± 0.31
Parietal Lobe7.53 ± 0.31
Pontine Tegmentum7.58 ± 0.28
Striatum7.45 ± 0.29
Subthalamus7.49 ± 0.32
Temporal Lobe7.56 ± 0.22
Thalamus7.57 ± 0.29
White Matter8.72 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tial1CBCerebellum62.55
100
Tial1CTXCerebral cortex100
100
Tial1HIPHippocampal region98.76
100
Tial1HPFHippocampal formation100
100
Tial1HYHypothalamus100
100
Tial1LSXLateral septal complex100
100
Tial1MBMidbrain93.98
97.82
Tial1MYMedulla63.56
74.04
Tial1OLFOlfactory bulb100
100
Tial1PPons64.5
71.62
Tial1PALPallidum100
100
Tial1RHPRetrohippocampal region100
100
Tial1sAMYStriatum-like amygdalar nuclei100
100
Tial1STRStriatum100
100
Tial1STRdStriatum dorsal region100
100
Tial1STRvStriatum ventral region100
100
Tial1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00434421 27 50 76 VNSSVGFSVLQHTSNDPYCFVEFYEHR Peptide Atlas
TIAR_HUMAN_1 9 1 9 MMEDDGQPR PRIDE
TIAR_HUMAN_2 8 2 9 MEDDGQPR PRIDE
TIAR_HUMAN_60 12 60 71 DAAAALAAMNGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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