AutismKB 2.0

Annotation Detail for TJP1


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Basic Information Top
Gene Symbol:TJP1 ( DKFZp686M05161,MGC133289,ZO-1 )
Gene Full Name: tight junction protein 1 (zona occludens 1)
Band: 15q13.1
Quick LinksEntrez ID:7082; OMIM: 601009; Uniprot ID:ZO1_HUMAN; ENSEMBL ID: ENSG00000104067; HGNC ID: 11827
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal22 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate8 / 18934542
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202011_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte122.65
AdrenalCortex63.8
Adrenalgland104.65
Amygdala417.15
Appendix191.35
AtrioventricularNode256.35
BDCA4+_DentriticCells6.65
Bonemarrow9.65
BronchialEpithelialCells330.8
CD105+_Endothelial6.3
CD14+_Monocytes6.5
CD19+_BCells(neg._sel.)8.95
CD33+_Myeloid9
CD34+7.3
CD4+_Tcells7.7
CD56+_NKCells7.9
CD71+_EarlyErythroid5.3
CD8+_Tcells6.45
CardiacMyocytes53.55
Caudatenucleus459.85
Cerebellum52.35
CerebellumPeduncles160
CiliaryGanglion203.5
CingulateCortex283.45
Colorectaladenocarcinoma251.45
DorsalRootGanglion231
FetalThyroid242.75
Fetalbrain193.4
Fetalliver36.45
Fetallung405.8
GlobusPallidus115.85
Heart48.2
Hypothalamus654.6
Kidney51.9
Leukemia_chronicMyelogenousK-56251.05
Leukemia_promyelocytic-HL-608.9
Leukemialymphoblastic(MOLT-4)5.8
Liver17
Lung226.05
Lymphnode101.9
Lymphoma_burkitts(Daudi)8.25
Lymphoma_burkitts(Raji)10.1
MedullaOblongata386.1
OccipitalLobe441.3
OlfactoryBulb686.95
Ovary52.05
Pancreas118.3
PancreaticIslet218.8
ParietalLobe382.4
Pituitary258.6
Placenta356.45
Pons212.05
PrefrontalCortex1050.1
Prostate277.6
Salivarygland157.4
SkeletalMuscle17.9
Skin118.45
SmoothMuscle228.2
Spinalcord773.1
SubthalamicNucleus186.45
SuperiorCervicalGanglion326.15
TemporalLobe148.9
Testis201.55
TestisGermCell719.8
TestisIntersitial288
TestisLeydigCell199.85
TestisSeminiferousTubule295.25
Thalamus252.9
Thymus16.35
Thyroid307.6
Tongue205.55
Tonsil109.45
Trachea112.35
TrigeminalGanglion63.05
Uterus664.65
UterusCorpus90
WholeBlood7.65
Wholebrain282.45
colon276.5
pineal_day278
pineal_night351.98
retina577.3
small_intestine291.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P205828
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.65 ± 0.43
Basal Forebrain8.84 ± 0.12
Basal Part of Pons8.55 ± 0.45
Cerebellar Cortex8.38 ± 0.5
Cerebellar Nuclei9.01 ± 0.36
Claustrum8.61 ± 0.41
Epithalamus8.32 ± 0.46
Frontal Lobe8.46 ± 0.41
Globus Pallidus9.44 ± 0.27
Hypothalamus8.28 ± 0.49
Insula8.37 ± 0.13
Limbic Lobe8.49 ± 0.45
Mesencephalon8.65 ± 0.39
Myelencephalon8.63 ± 0.39
Occipital Lobe8.72 ± 0.39
Parietal Lobe8.47 ± 0.36
Pontine Tegmentum8.61 ± 0.42
Striatum9.06 ± 0.49
Subthalamus8.55 ± 0.13
Temporal Lobe8.41 ± 0.33
Thalamus8.67 ± 0.29
White Matter9.86 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tjp1CBCerebellum13.19
15.29
Tjp1CTXCerebral cortex32.73
25.01
Tjp1HIPHippocampal region19.69
20.37
Tjp1HPFHippocampal formation15.73
15.09
Tjp1HYHypothalamus5.92
5.65
Tjp1LSXLateral septal complex2.04
1.53
Tjp1MBMidbrain8.01
7.83
Tjp1MYMedulla13.23
13.31
Tjp1OLFOlfactory bulb45.26
37.24
Tjp1PPons6.01
6.12
Tjp1PALPallidum7.8
6.63
Tjp1RHPRetrohippocampal region9.1
7.76
Tjp1sAMYStriatum-like amygdalar nuclei13.36
11.48
Tjp1STRStriatum10.29
7.71
Tjp1STRdStriatum dorsal region8.92
6.81
Tjp1STRvStriatum ventral region17
11.21
Tjp1THThalamus12.08
12.51
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039919 29 1678 1706 DNSILPPLDKEKGETLLSPLVMCGPHGLK Peptide Atlas
ZO1_HUMAN_75 22 75 96 VAMVNGVSMDNVEHAFAVQQLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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