Annotation Detail for TLE1
Basic Information Top
| Gene Symbol: | TLE1 ( ESG,ESG1,GRG1 ) |
|---|---|
| Gene Full Name: | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
| Band: | 9q21.32 |
| Quick Links | Entrez ID:7088; OMIM: 600189; Uniprot ID:TLE1_HUMAN; ENSEMBL ID: ENSG00000196781; HGNC ID: 11837 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.689805
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 3 / 70761 | 42 |  |
| blastocyst | 10 / 62319 | 160 |  |
| fetus | 57 / 564012 | 101 | |
| neonate | 0 / 31097 | 0 | |
| infant | 2 / 23620 | 84 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 150 / 1939121 | 77 | |
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 0 / 564012 | 0 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 0 / 1939121 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 2 / 12794 | 156 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 8 / 82823 | 96 | |
| colorectal tumor | 9 / 114246 | 78 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 87 / 119369 | 728 |  |
| germ cell tumor | 26 / 263845 | 98 | |
| glioma | 14 / 106883 | 130 | |
| head and neck tumor | 3 / 136302 | 22 | |
| kidney tumor | 10 / 68959 | 145 | |
| leukemia | 6 / 95842 | 62 | |
| liver tumor | 4 / 96359 | 41 | |
| lung tumor | 10 / 103127 | 96 | |
| lymphoma | 1 / 71755 | 13 | |
| non-neoplasia | 4 / 97250 | 41 | |
| normal | 230 / 3360307 | 68 | |
| ovarian tumor | 11 / 76682 | 143 | |
| pancreatic tumor | 7 / 104616 | 66 | |
| primitive neuroectodermal tumor of the CNS | 14 / 125680 | 111 | |
| prostate cancer | 1 / 102680 | 9 |  |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 11 / 124949 | 88 | |
| soft tissue/muscle tissue tumor | 7 / 125191 | 55 | |
| uterine tumor | 12 / 90257 | 132 | |
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 1 / 3360307 | 0 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 75 / 40015 | 1874 |  |
| bladder | 1 / 29757 | 33 | |
| blood | 6 / 123478 | 48 | |
| bone | 4 / 71655 | 55 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 49 / 1100989 | 44 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 9 / 149255 | 60 | |
| ear | 2 / 16212 | 123 | |
| embryonic tissue | 20 / 215722 | 92 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 27 / 211054 | 127 | |
| heart | 16 / 89626 | 178 | |
| intestine | 22 / 234472 | 93 | |
| kidney | 15 / 211777 | 70 | |
| larynx | 0 / 24145 | 0 | |
| liver | 12 / 207743 | 57 | |
| lung | 34 / 336974 | 100 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 10 / 91610 | 109 | |
| mammary gland | 7 / 153271 | 45 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 6 / 107715 | 55 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 15 / 102051 | 146 | |
| pancreas | 20 / 214812 | 93 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 24 / 280825 | 85 | |
| prostate | 7 / 189345 | 36 | |
| salivary gland | 2 / 20155 | 99 | |
| skin | 27 / 210574 | 128 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 8 / 96619 | 82 | |
| testis | 24 / 330442 | 72 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 17 / 232878 | 72 | |
| vascular | 1 / 51780 | 19 | |
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 0 / 1100989 | 0 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203222_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.6 | |
| Adipocyte | 9 | |
| AdrenalCortex | 12.2 | |
| Adrenalgland | 9.4 | |
| Amygdala | 20.9 | |
| Appendix | 9.9 | |
| AtrioventricularNode | 8.1 | |
| BDCA4+_DentriticCells | 10.65 | |
| Bonemarrow | 10.7 | |
| BronchialEpithelialCells | 8.25 | |
| CD105+_Endothelial | 19.4 | |
| CD14+_Monocytes | 9.1 | |
| CD19+_BCells(neg._sel.) | 29.4 | |
| CD33+_Myeloid | 11.4 | |
| CD34+ | 13.1 | |
| CD4+_Tcells | 8.05 | |
| CD56+_NKCells | 49.45 | |
| CD71+_EarlyErythroid | 9.65 | |
| CD8+_Tcells | 7.1 | |
| CardiacMyocytes | 18.8 | |
| Caudatenucleus | 8.75 | |
| Cerebellum | 7.55 | |
| CerebellumPeduncles | 11.25 | |
| CiliaryGanglion | 7.3 | |
| CingulateCortex | 12.95 | |
| Colorectaladenocarcinoma | 9.4 | |
| DorsalRootGanglion | 7.35 | |
| FetalThyroid | 9.2 | |
| Fetalbrain | 11.45 | |
| Fetalliver | 8.45 | |
| Fetallung | 8.3 | |
| GlobusPallidus | 7.1 | |
| Heart | 45.5 | |
| Hypothalamus | 8.65 | |
| Kidney | 7.75 | |
| Leukemia_chronicMyelogenousK-562 | 7.25 | |
| Leukemia_promyelocytic-HL-60 | 8 | |
| Leukemialymphoblastic(MOLT-4) | 7.45 | |
| Liver | 18.05 | |
| Lung | 38.25 | |
| Lymphnode | 8.2 | |
| Lymphoma_burkitts(Daudi) | 11.55 | |
| Lymphoma_burkitts(Raji) | 14.3 | |
| MedullaOblongata | 8.1 | |
| OccipitalLobe | 8.8 | |
| OlfactoryBulb | 10.45 | |
| Ovary | 9.3 | |
| Pancreas | 8.7 | |
| PancreaticIslet | 9.45 | |
| ParietalLobe | 10.2 | |
| Pituitary | 10.8 | |
| Placenta | 12.65 | |
| Pons | 9.25 | |
| PrefrontalCortex | 12.3 | |
| Prostate | 11.95 | |
| Salivarygland | 7.95 | |
| SkeletalMuscle | 14.1 | |
| Skin | 8.85 | |
| SmoothMuscle | 11.1 | |
| Spinalcord | 9.85 | |
| SubthalamicNucleus | 8.75 | |
| SuperiorCervicalGanglion | 14.45 | |
| TemporalLobe | 8.5 | |
| Testis | 11.75 | |
| TestisGermCell | 8.25 | |
| TestisIntersitial | 8.4 | |
| TestisLeydigCell | 9.35 | |
| TestisSeminiferousTubule | 8.3 | |
| Thalamus | 9.45 | |
| Thymus | 7.4 | |
| Thyroid | 22.05 | |
| Tongue | 10.85 | |
| Tonsil | 9.35 | |
| Trachea | 7.65 | |
| TrigeminalGanglion | 11.35 | |
| Uterus | 51.55 | |
| UterusCorpus | 8.75 | |
| WholeBlood | 8.9 | |
| Wholebrain | 15.8 | |
| colon | 8.7 | |
| pineal_day | 35.54 | |
| pineal_night | 29 | |
| retina | 12.7 | |
| small_intestine | 7.8 | |
- Probe name: CUST_13994_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 8.18 ± 0.3 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.86 ± 0.12 | |
| Basal Part of Pons | 7.42 ± 0.25 | |
| Cerebellar Cortex | 7.65 ± 0.16 | |
| Cerebellar Nuclei | 7.49 ± 0.22 | |
| Claustrum | 7.3 ± 0.35 | |
| Epithalamus | 7.59 ± 0.28 | |
| Frontal Lobe | 7.7 ± 0.33 | |
| Globus Pallidus | 7.57 ± 0.12 | |
| Hypothalamus | 7.58 ± 0.35 | |
| Insula | 8.09 ± 0.23 | |
| Limbic Lobe | 8.03 ± 0.45 | |
| Mesencephalon | 7.79 ± 0.33 | |
| Myelencephalon | 7.84 ± 0.36 | |
| Occipital Lobe | 7.83 ± 0.37 | |
| Parietal Lobe | 7.91 ± 0.37 | |
| Pontine Tegmentum | 7.89 ± 0.27 | |
| Striatum | 8.44 ± 0.23 | |
| Subthalamus | 8.12 ± 0.31 | |
| Temporal Lobe | 8.1 ± 0.29 | |
| Thalamus | 7.85 ± 0.42 | |
| White Matter | 6.72 ± 0.35 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Tle1 | CB | Cerebellum | 3.92 | |
| 3.28 | | |||
| Tle1 | CTX | Cerebral cortex | 11.41 | |
| 8.71 | | |||
| Tle1 | HIP | Hippocampal region | 39.03 | |
| 40.09 | | |||
| Tle1 | HPF | Hippocampal formation | 32.72 | |
| 30.85 | | |||
| Tle1 | HY | Hypothalamus | 5.51 | |
| 3.67 | | |||
| Tle1 | LSX | Lateral septal complex | 5.81 | |
| 3.27 | | |||
| Tle1 | MB | Midbrain | 5.97 | |
| 4.34 | | |||
| Tle1 | MY | Medulla | 8.26 | |
| 7.71 | | |||
| Tle1 | OLF | Olfactory bulb | 10.57 | |
| 7.15 | | |||
| Tle1 | P | Pons | 7.09 | |
| 6.29 | | |||
| Tle1 | PAL | Pallidum | 4.21 | |
| 3.42 | | |||
| Tle1 | RHP | Retrohippocampal region | 21.45 | |
| 18.96 | | |||
| Tle1 | sAMY | Striatum-like amygdalar nuclei | 5.58 | |
| 3.85 | | |||
| Tle1 | STR | Striatum | 11.29 | |
| 7.79 | | |||
| Tle1 | STRd | Striatum dorsal region | 12.96 | |
| 9.29 | | |||
| Tle1 | STRv | Striatum ventral region | 10.29 | |
| 6.43 | | |||
| Tle1 | TH | Thalamus | 4.17 | |
| 2.9 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00028848 | 14 | 692 | 705 | YQLHLHESCVLSLK | Peptide Atlas |