AutismKB 2.0

Annotation Detail for TLE2


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Basic Information Top
Gene Symbol:TLE2 ( ESG,ESG2,FLJ41188,GRG2 )
Gene Full Name: transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Band: 19p13.3
Quick LinksEntrez ID:7089; OMIM: 601041; Uniprot ID:TLE2_HUMAN; ENSEMBL ID: ENSG00000065717; HGNC ID: 11838
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult77 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor4 / 26384515
glioma13 / 106883121
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal118 / 336030735
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain48 / 110098943
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye16 / 21105475
heart1 / 8962611
intestine12 / 23447251
kidney2 / 2117779
larynx0 / 241450 
liver6 / 20774328
lung21 / 33697462
lymph0 / 442700 
lymph node0 / 916100 
mammary gland14 / 15327191
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate19 / 189345100
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach4 / 9661941
testis4 / 33044212
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204431_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.75
Adipocyte5.05
AdrenalCortex5.9
Adrenalgland4.3
Amygdala6.45
Appendix5.2
AtrioventricularNode5.45
BDCA4+_DentriticCells5.25
Bonemarrow6.3
BronchialEpithelialCells5
CD105+_Endothelial5.2
CD14+_Monocytes4.7
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid6.7
CD34+6.45
CD4+_Tcells6.65
CD56+_NKCells6.15
CD71+_EarlyErythroid5.1
CD8+_Tcells5.45
CardiacMyocytes6.5
Caudatenucleus4.55
Cerebellum24.35
CerebellumPeduncles20
CiliaryGanglion3.55
CingulateCortex5.05
Colorectaladenocarcinoma5.2
DorsalRootGanglion3.95
FetalThyroid7.45
Fetalbrain8.15
Fetalliver3.85
Fetallung15.9
GlobusPallidus3.7
Heart28.15
Hypothalamus5.7
Kidney4.05
Leukemia_chronicMyelogenousK-56210
Leukemia_promyelocytic-HL-603.9
Leukemialymphoblastic(MOLT-4)3.95
Liver6.7
Lung28.05
Lymphnode4.25
Lymphoma_burkitts(Daudi)5.7
Lymphoma_burkitts(Raji)10.4
MedullaOblongata4.5
OccipitalLobe4.45
OlfactoryBulb5.1
Ovary3.35
Pancreas4.05
PancreaticIslet5.45
ParietalLobe5.25
Pituitary5.95
Placenta7.25
Pons4.8
PrefrontalCortex6.45
Prostate26
Salivarygland4.05
SkeletalMuscle6.85
Skin3.9
SmoothMuscle5.65
Spinalcord7.5
SubthalamicNucleus4.55
SuperiorCervicalGanglion5.95
TemporalLobe4.55
Testis4.4
TestisGermCell4.35
TestisIntersitial5.1
TestisLeydigCell5
TestisSeminiferousTubule4.2
Thalamus5.15
Thymus4.05
Thyroid82.3
Tongue4.9
Tonsil4.85
Trachea4.35
TrigeminalGanglion5.1
Uterus23.6
UterusCorpus4.55
WholeBlood5.25
Wholebrain4.4
colon5.65
pineal_day6.06
pineal_night6.26
retina101.275
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P153676
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.99 ± 0.45
Basal Forebrain8.29 ± 0.73
Basal Part of Pons8.11 ± 0.24
Cerebellar Cortex8.27 ± 0.53
Cerebellar Nuclei8.01 ± 0.24
Claustrum8.72 ± 0.42
Epithalamus6.44 ± 0.88
Frontal Lobe7.26 ± 0.61
Globus Pallidus7.02 ± 0.37
Hypothalamus7.59 ± 1.08
Insula7.43 ± 0.42
Limbic Lobe7.01 ± 0.52
Mesencephalon7.56 ± 0.75
Myelencephalon7.47 ± 0.74
Occipital Lobe7.91 ± 0.68
Parietal Lobe7.54 ± 0.56
Pontine Tegmentum7.2 ± 0.61
Striatum6.13 ± 0.52
Subthalamus8.08 ± 0.27
Temporal Lobe7.39 ± 0.45
Thalamus7.13 ± 0.52
White Matter7.46 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tle2CBCerebellum8.69
9.72
Tle2CTXCerebral cortex5.42
4.13
Tle2HIPHippocampal region5.36
5.17
Tle2HPFHippocampal formation4.78
4.04
Tle2HYHypothalamus3.11
1.99
Tle2LSXLateral septal complex3.77
2.36
Tle2MBMidbrain6.22
5.23
Tle2MYMedulla4.46
3.44
Tle2OLFOlfactory bulb11.93
10.08
Tle2PPons6.48
5.17
Tle2PALPallidum2.85
1.98
Tle2RHPRetrohippocampal region3.73
2.45
Tle2sAMYStriatum-like amygdalar nuclei1.83
1.02
Tle2STRStriatum3.08
1.87
Tle2STRdStriatum dorsal region2.83
1.75
Tle2STRvStriatum ventral region4.25
2.46
Tle2THThalamus2.74
2.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00028848 14 665 678 YQLHLHESCVLSLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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