AutismKB 2.0

Annotation Detail for TLR3


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Basic Information Top
Gene Symbol:TLR3 ( CD283 )
Gene Full Name: toll-like receptor 3
Band: 4q35.1
Quick LinksEntrez ID:7098; OMIM: 603029; Uniprot ID:TLR3_HUMAN; ENSEMBL ID: ENSG00000164342; HGNC ID: 11849
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal58 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine2 / 2344728
kidney4 / 21177718
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta26 / 28082592
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach2 / 9661920
testis3 / 3304429
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206271_at
Cell line Expression level Expression bar
721_B_lymphoblasts8
Adipocyte6.5
AdrenalCortex8.3
Adrenalgland5.9
Amygdala6.55
Appendix8.3
AtrioventricularNode6.75
BDCA4+_DentriticCells7.1
Bonemarrow7.2
BronchialEpithelialCells6.4
CD105+_Endothelial6.8
CD14+_Monocytes7.15
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid8
CD34+8.35
CD4+_Tcells7.15
CD56+_NKCells7.8
CD71+_EarlyErythroid6.5
CD8+_Tcells5.9
CardiacMyocytes10.95
Caudatenucleus6.1
Cerebellum5.45
CerebellumPeduncles8.05
CiliaryGanglion5.5
CingulateCortex7.05
Colorectaladenocarcinoma6.8
DorsalRootGanglion5.9
FetalThyroid6.8
Fetalbrain6.6
Fetalliver6.05
Fetallung5.15
GlobusPallidus5.2
Heart11.1
Hypothalamus6.95
Kidney5.9
Leukemia_chronicMyelogenousK-5626.15
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.15
Liver10.15
Lung7.5
Lymphnode5.8
Lymphoma_burkitts(Daudi)8.9
Lymphoma_burkitts(Raji)10.5
MedullaOblongata6.25
OccipitalLobe5.9
OlfactoryBulb5.2
Ovary5.1
Pancreas5.65
PancreaticIslet7.25
ParietalLobe7.45
Pituitary7.85
Placenta11.7
Pons6.7
PrefrontalCortex7.9
Prostate7.8
Salivarygland5.55
SkeletalMuscle9.8
Skin6.05
SmoothMuscle7.75
Spinalcord7.15
SubthalamicNucleus6.4
SuperiorCervicalGanglion9.75
TemporalLobe6.4
Testis5.75
TestisGermCell5.6
TestisIntersitial10.5
TestisLeydigCell7.35
TestisSeminiferousTubule5.85
Thalamus6.95
Thymus4.9
Thyroid8.65
Tongue7.65
Tonsil6.7
Trachea5.55
TrigeminalGanglion8.5
Uterus5.5
UterusCorpus6.85
WholeBlood7.25
Wholebrain5.15
colon6.85
pineal_day8.2
pineal_night7.98
retina8.075
small_intestine6.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16146_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.36 ± 0.69
Basal Forebrain4.26 ± 0.37
Basal Part of Pons3.67 ± 0.45
Cerebellar Cortex3.81 ± 0.34
Cerebellar Nuclei4.72 ± 0.56
Claustrum4.2 ± 1.05
Epithalamus4.96 ± 0.51
Frontal Lobe4.1 ± 0.58
Globus Pallidus5.75 ± 0.34
Hypothalamus4.19 ± 0.64
Insula3.99 ± 0.49
Limbic Lobe4.2 ± 0.64
Mesencephalon4.28 ± 0.56
Myelencephalon4.28 ± 0.64
Occipital Lobe4.13 ± 0.63
Parietal Lobe4.06 ± 0.61
Pontine Tegmentum4.33 ± 0.59
Striatum4.74 ± 0.54
Subthalamus4.39 ± 0.25
Temporal Lobe4.04 ± 0.56
Thalamus4.2 ± 0.4
White Matter5.27 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tlr3CBCerebellum1.06
1.13
Tlr3CTXCerebral cortex0.77
0.72
Tlr3HIPHippocampal region1.03
0.87
Tlr3HPFHippocampal formation0.89
0.74
Tlr3HYHypothalamus0.15
0.19
Tlr3LSXLateral septal complex0.15
0.14
Tlr3MBMidbrain0.87
1.58
Tlr3MYMedulla0.67
0.82
Tlr3OLFOlfactory bulb3.29
3.43
Tlr3PPons0.59
0.82
Tlr3PALPallidum0.11
0.12
Tlr3RHPRetrohippocampal region0.46
0.43
Tlr3sAMYStriatum-like amygdalar nuclei0.24
0.2
Tlr3STRStriatum0.28
0.21
Tlr3STRdStriatum dorsal region0.33
0.25
Tlr3STRvStriatum ventral region0.2
0.11
Tlr3THThalamus0.27
0.26
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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