Annotation Detail for TLR4
Basic Information Top
| Gene Symbol: | TLR4 ( ARMD10,CD284,TOLL,hToll ) |
|---|---|
| Gene Full Name: | toll-like receptor 4 |
| Band: | 9q33.1 |
| Quick Links | Entrez ID:7099; OMIM: 603030; Uniprot ID:TLR4_HUMAN; ENSEMBL ID: ENSG00000136869; HGNC ID: 11850 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.174312
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 1 / 62319 | 16 | |
| fetus | 7 / 564012 | 12 | |
| neonate | 2 / 31097 | 64 |  |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 23 / 1939121 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 1 / 114246 | 8 |  |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 | |
| germ cell tumor | 1 / 263845 | 3 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 2 / 95842 | 20 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 6 / 97250 | 61 | |
| normal | 81 / 3360307 | 24 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 8 / 123478 | 64 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 4 / 48801 | 81 | |
| brain | 26 / 1100989 | 23 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 7 / 149255 | 46 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 4 / 215722 | 18 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 5 / 211054 | 23 | |
| heart | 0 / 89626 | 0 | |
| intestine | 2 / 234472 | 8 | |
| kidney | 9 / 211777 | 42 | |
| larynx | 0 / 24145 | 0 | |
| liver | 6 / 207743 | 28 | |
| lung | 5 / 336974 | 14 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 6 / 280825 | 21 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 3 / 210574 | 14 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 1 / 96619 | 10 | |
| testis | 3 / 330442 | 9 | |
| thymus | 1 / 81131 | 12 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 8 / 52413 | 152 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 4 / 232878 | 17 | |
| vascular | 3 / 51780 | 57 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 221060_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6.4 | |
| Adipocyte | 4.95 | |
| AdrenalCortex | 5.5 | |
| Adrenalgland | 4.3 | |
| Amygdala | 5.25 | |
| Appendix | 5.5 | |
| AtrioventricularNode | 4.1 | |
| BDCA4+_DentriticCells | 5.75 | |
| Bonemarrow | 5.3 | |
| BronchialEpithelialCells | 5.05 | |
| CD105+_Endothelial | 5.25 | |
| CD14+_Monocytes | 45.1 | |
| CD19+_BCells(neg._sel.) | 5.45 | |
| CD33+_Myeloid | 197.25 | |
| CD34+ | 6.55 | |
| CD4+_Tcells | 5.45 | |
| CD56+_NKCells | 6.15 | |
| CD71+_EarlyErythroid | 4.75 | |
| CD8+_Tcells | 4.75 | |
| CardiacMyocytes | 6.55 | |
| Caudatenucleus | 4.55 | |
| Cerebellum | 4.1 | |
| CerebellumPeduncles | 5.85 | |
| CiliaryGanglion | 4.15 | |
| CingulateCortex | 5.25 | |
| Colorectaladenocarcinoma | 5.05 | |
| DorsalRootGanglion | 4.15 | |
| FetalThyroid | 4.95 | |
| Fetalbrain | 5.1 | |
| Fetalliver | 4.5 | |
| Fetallung | 4.25 | |
| GlobusPallidus | 3.85 | |
| Heart | 6.6 | |
| Hypothalamus | 5.6 | |
| Kidney | 4.35 | |
| Leukemia_chronicMyelogenousK-562 | 4.6 | |
| Leukemia_promyelocytic-HL-60 | 4.45 | |
| Leukemialymphoblastic(MOLT-4) | 4.05 | |
| Liver | 6.7 | |
| Lung | 5.55 | |
| Lymphnode | 4.4 | |
| Lymphoma_burkitts(Daudi) | 6.5 | |
| Lymphoma_burkitts(Raji) | 7.1 | |
| MedullaOblongata | 4.7 | |
| OccipitalLobe | 4.55 | |
| OlfactoryBulb | 4.05 | |
| Ovary | 3.55 | |
| Pancreas | 4.05 | |
| PancreaticIslet | 5.4 | |
| ParietalLobe | 5.45 | |
| Pituitary | 5.95 | |
| Placenta | 5.35 | |
| Pons | 4.85 | |
| PrefrontalCortex | 6.45 | |
| Prostate | 5.9 | |
| Salivarygland | 4.15 | |
| SkeletalMuscle | 6.8 | |
| Skin | 4.2 | |
| SmoothMuscle | 5.95 | |
| Spinalcord | 5.45 | |
| SubthalamicNucleus | 4.65 | |
| SuperiorCervicalGanglion | 6.35 | |
| TemporalLobe | 4.7 | |
| Testis | 4.4 | |
| TestisGermCell | 4.25 | |
| TestisIntersitial | 4.4 | |
| TestisLeydigCell | 5.1 | |
| TestisSeminiferousTubule | 4.35 | |
| Thalamus | 5.2 | |
| Thymus | 4 | |
| Thyroid | 6.2 | |
| Tongue | 5.15 | |
| Tonsil | 5 | |
| Trachea | 4.25 | |
| TrigeminalGanglion | 8.35 | |
| Uterus | 4.1 | |
| UterusCorpus | 5.1 | |
| WholeBlood | 71.35 | |
| Wholebrain | 4.2 | |
| colon | 5.15 | |
| pineal_day | 6.9 | |
| pineal_night | 6.28 | |
| retina | 6.225 | |
| small_intestine | 4.9 | |
- Probe name: A_32_P66881
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.17 ± 0.59 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.19 ± 0.74 | |
| Basal Part of Pons | 4.61 ± 0.87 | |
| Cerebellar Cortex | 4.49 ± 0.35 | |
| Cerebellar Nuclei | 4.9 ± 0.83 | |
| Claustrum | 4.28 ± 1.1 | |
| Epithalamus | 5.07 ± 0.54 | |
| Frontal Lobe | 5.03 ± 0.56 | |
| Globus Pallidus | 6.61 ± 0.41 | |
| Hypothalamus | 5.43 ± 0.68 | |
| Insula | 5.28 ± 0.4 | |
| Limbic Lobe | 4.77 ± 0.72 | |
| Mesencephalon | 5.61 ± 0.63 | |
| Myelencephalon | 5.25 ± 0.75 | |
| Occipital Lobe | 5.53 ± 0.48 | |
| Parietal Lobe | 5.17 ± 0.65 | |
| Pontine Tegmentum | 5.28 ± 0.59 | |
| Striatum | 6.44 ± 0.54 | |
| Subthalamus | 5.71 ± 0.44 | |
| Temporal Lobe | 5.23 ± 0.47 | |
| Thalamus | 5.51 ± 0.59 | |
| White Matter | 3.64 ± 0.11 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Tlr4 | CB | Cerebellum | 0.23 | |
| 0.62 | | |||
| Tlr4 | CTX | Cerebral cortex | 1.03 | |
| 1.03 | | |||
| Tlr4 | HIP | Hippocampal region | 0.26 | |
| 0.33 | | |||
| Tlr4 | HPF | Hippocampal formation | 0.24 | |
| 0.28 | | |||
| Tlr4 | HY | Hypothalamus | 0.25 | |
| 0.33 | | |||
| Tlr4 | LSX | Lateral septal complex | 0.2 | |
| 0.15 | | |||
| Tlr4 | MB | Midbrain | 0.52 | |
| 0.81 | | |||
| Tlr4 | MY | Medulla | 0.25 | |
| 0.3 | | |||
| Tlr4 | OLF | Olfactory bulb | 1.27 | |
| 2.38 | | |||
| Tlr4 | P | Pons | 0.4 | |
| 0.77 | | |||
| Tlr4 | PAL | Pallidum | 0.04 | |
| 0.02 | | |||
| Tlr4 | RHP | Retrohippocampal region | 0.2 | |
| 0.21 | | |||
| Tlr4 | sAMY | Striatum-like amygdalar nuclei | 0.36 | |
| 0.69 | | |||
| Tlr4 | STR | Striatum | 0.28 | |
| 0.7 | | |||
| Tlr4 | STRd | Striatum dorsal region | 0.33 | |
| 0.96 | | |||
| Tlr4 | STRv | Striatum ventral region | 0.08 | |
| 0.07 | | |||
| Tlr4 | TH | Thalamus | 0.39 | |
| 0.37 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| TLR4_HUMAN_561 | 34 | 561 | 594 | QELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIK | PRIDE |