AutismKB 2.0

Annotation Detail for TNFAIP2


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Basic Information Top
Gene Symbol:TNFAIP2 ( B94 )
Gene Full Name: tumor necrosis factor, alpha-induced protein 2
Band: 14q32
Quick LinksEntrez ID:7127; OMIM: 603300; Uniprot ID:TNAP2_HUMAN; ENSEMBL ID: ENSG00000185215; HGNC ID: 11895
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus28 / 56401249
neonate0 / 310970 
infant4 / 23620169
juvenile0 / 555560 
adult171 / 193912188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma5 / 17475286
breast (mammary gland) tumor2 / 9417821
cervical tumor4 / 34366116
chondrosarcoma5 / 8282360
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor3 / 26384511
glioma6 / 10688356
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor21 / 103127203
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal163 / 336030748
ovarian tumor6 / 7668278
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer13 / 102680126
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites6 / 40015149
bladder8 / 29757268
blood8 / 12347864
bone10 / 71655139
bone marrow3 / 4880161
brain22 / 110098919
cervix4 / 4817183
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye11 / 21105452
heart6 / 8962666
intestine6 / 23447225
kidney8 / 21177737
larynx2 / 2414582
liver8 / 20774338
lung59 / 336974175
lymph0 / 442700 
lymph node0 / 916100 
mammary gland18 / 153271117
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary7 / 10205168
pancreas18 / 21481283
parathyroid9 / 20539438
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta18 / 28082564
prostate20 / 189345105
salivary gland2 / 2015599
skin5 / 21057423
spleen2 / 5395237
stomach4 / 9661941
testis7 / 33044221
thymus6 / 8113173
thyroid6 / 47473126
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus30 / 232878128
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202510_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.8
Adipocyte4.75
AdrenalCortex6
Adrenalgland7.35
Amygdala4.95
Appendix4.8
AtrioventricularNode3.6
BDCA4+_DentriticCells110.2
Bonemarrow5.25
BronchialEpithelialCells4.55
CD105+_Endothelial24.7
CD14+_Monocytes862.6
CD19+_BCells(neg._sel.)4.9
CD33+_Myeloid1102.2
CD34+20.5
CD4+_Tcells5.05
CD56+_NKCells23.1
CD71+_EarlyErythroid4.45
CD8+_Tcells4.5
CardiacMyocytes5.9
Caudatenucleus4.3
Cerebellum3.85
CerebellumPeduncles5.4
CiliaryGanglion3.5
CingulateCortex5.9
Colorectaladenocarcinoma17.1
DorsalRootGanglion3.65
FetalThyroid4.65
Fetalbrain6.7
Fetalliver4.2
Fetallung247.45
GlobusPallidus3.5
Heart6.55
Hypothalamus5.3
Kidney3.9
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.25
Leukemialymphoblastic(MOLT-4)3.75
Liver6.3
Lung5.9
Lymphnode198.05
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)6.65
MedullaOblongata4.3
OccipitalLobe4.2
OlfactoryBulb3.8
Ovary3.2
Pancreas3.85
PancreaticIslet20.4
ParietalLobe4.95
Pituitary5.6
Placenta28.4
Pons4.5
PrefrontalCortex5.9
Prostate5.7
Salivarygland8.85
SkeletalMuscle6.5
Skin3.85
SmoothMuscle8.75
Spinalcord5.5
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.7
TemporalLobe4.35
Testis5.9
TestisGermCell4.3
TestisIntersitial9.95
TestisLeydigCell4.75
TestisSeminiferousTubule4.5
Thalamus4.95
Thymus8.15
Thyroid5.9
Tongue4.8
Tonsil78.85
Trachea12
TrigeminalGanglion5
Uterus3.9
UterusCorpus5.75
WholeBlood585.05
Wholebrain4
colon4.8
pineal_day5.8
pineal_night5.62
retina6.875
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P421423
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.46 ± 0.43
Basal Forebrain8.69 ± 0.19
Basal Part of Pons9.09 ± 0.2
Cerebellar Cortex8.03 ± 0.25
Cerebellar Nuclei8.7 ± 0.26
Claustrum8.13 ± 0.45
Epithalamus8.39 ± 0.36
Frontal Lobe8.4 ± 0.38
Globus Pallidus8.65 ± 0.39
Hypothalamus8.83 ± 0.36
Insula8.81 ± 0.31
Limbic Lobe8.19 ± 0.61
Mesencephalon8.43 ± 0.46
Myelencephalon8.52 ± 0.52
Occipital Lobe8.26 ± 0.51
Parietal Lobe8.39 ± 0.44
Pontine Tegmentum8.3 ± 0.45
Striatum8.9 ± 0.49
Subthalamus8.11 ± 0.24
Temporal Lobe8.59 ± 0.44
Thalamus8.79 ± 0.53
White Matter6.92 ± 0.02
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfaip2CBCerebellum1.58
1.81
Tnfaip2CTXCerebral cortex2.04
1.43
Tnfaip2HIPHippocampal region1.17
1.06
Tnfaip2HPFHippocampal formation1.19
1.03
Tnfaip2HYHypothalamus0.24
0.27
Tnfaip2LSXLateral septal complex0.46
0.39
Tnfaip2MBMidbrain0.98
1
Tnfaip2MYMedulla0.76
0.58
Tnfaip2OLFOlfactory bulb3.87
4.3
Tnfaip2PPons0.52
0.77
Tnfaip2PALPallidum0.48
0.33
Tnfaip2RHPRetrohippocampal region1.22
0.98
Tnfaip2sAMYStriatum-like amygdalar nuclei0.69
0.76
Tnfaip2STRStriatum0.41
0.35
Tnfaip2STRdStriatum dorsal region0.39
0.31
Tnfaip2STRvStriatum ventral region0.4
0.37
Tnfaip2THThalamus0.83
0.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096349 23 352 374 LDGHCHSELAIDIIQITSQAQAK Peptide Atlas
TNAP2_HUMAN_2 20 2 21 SEASSEDLVPPLEAGAAPYR PRIDE
TNAP2_HUMAN_206 17 206 222 PAAGAEVPESVFLHLGR PRIDE
TNAP2_HUMAN_295 17 295 311 LVGELQGMGLGSLLPPR PRIDE
TNAP2_HUMAN_96 7 96 102 PLLALER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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