AutismKB 2.0

Annotation Detail for TNFAIP3


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Basic Information Top
Gene Symbol:TNFAIP3 ( A20,MGC104522,MGC138687,MGC138688,OTUD7C,TNFA1P2 )
Gene Full Name: tumor necrosis factor, alpha-induced protein 3
Band: 6q23.3
Quick LinksEntrez ID:7128; OMIM: 191163; Uniprot ID:TNAP3_HUMAN; ENSEMBL ID: ENSG00000118503; HGNC ID: 11896
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult137 / 193912170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor4 / 34366116
chondrosarcoma7 / 8282384
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma4 / 10688337
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma6 / 7175583
non-neoplasia3 / 9725030
normal165 / 336030749
ovarian tumor5 / 7668265
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone0 / 716550 
bone marrow6 / 48801122
brain16 / 110098914
cervix4 / 4817183
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye7 / 21105433
heart2 / 8962622
intestine12 / 23447251
kidney10 / 21177747
larynx4 / 24145165
liver4 / 20774319
lung35 / 336974103
lymph1 / 4427022
lymph node17 / 91610185
mammary gland1 / 1532716
mouth3 / 6705244
muscle4 / 10771537
nerve0 / 157680 
ovary7 / 10205168
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate1 / 1893455
salivary gland0 / 201550 
skin7 / 21057433
spleen5 / 5395292
stomach3 / 9661931
testis13 / 33044239
thymus14 / 81131172
thyroid0 / 474730 
tonsil0 / 169990 
trachea23 / 52413438
umbilical cord0 / 136800 
uterus13 / 23287855
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202644_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts995
Adipocyte6.4
AdrenalCortex22.35
Adrenalgland28.6
Amygdala4
Appendix7.55
AtrioventricularNode5.05
BDCA4+_DentriticCells854.65
Bonemarrow21.5
BronchialEpithelialCells106.65
CD105+_Endothelial39.8
CD14+_Monocytes143.25
CD19+_BCells(neg._sel.)214.2
CD33+_Myeloid1292.15
CD34+117.45
CD4+_Tcells992.5
CD56+_NKCells1033.5
CD71+_EarlyErythroid3.7
CD8+_Tcells853.6
CardiacMyocytes48.85
Caudatenucleus4.1
Cerebellum3.15
CerebellumPeduncles5.5
CiliaryGanglion5.2
CingulateCortex4.6
Colorectaladenocarcinoma3.7
DorsalRootGanglion4.05
FetalThyroid5.8
Fetalbrain10.3
Fetalliver5.3
Fetallung333.4
GlobusPallidus2.95
Heart5.15
Hypothalamus6.1
Kidney3.15
Leukemia_chronicMyelogenousK-5626.5
Leukemia_promyelocytic-HL-60109.1
Leukemialymphoblastic(MOLT-4)91.75
Liver6.85
Lung304.4
Lymphnode252.3
Lymphoma_burkitts(Daudi)10.45
Lymphoma_burkitts(Raji)295.05
MedullaOblongata4.45
OccipitalLobe3.3
OlfactoryBulb16.5
Ovary122.05
Pancreas5.9
PancreaticIslet41.15
ParietalLobe4
Pituitary17.35
Placenta58.7
Pons5.3
PrefrontalCortex4.55
Prostate29.65
Salivarygland19.25
SkeletalMuscle4.45
Skin23.45
SmoothMuscle493.95
Spinalcord6.15
SubthalamicNucleus3.4
SuperiorCervicalGanglion7.65
TemporalLobe3.35
Testis29.4
TestisGermCell8.45
TestisIntersitial6.05
TestisLeydigCell4.55
TestisSeminiferousTubule3.5
Thalamus3.9
Thymus262.95
Thyroid14.6
Tongue3.75
Tonsil145.3
Trachea139.5
TrigeminalGanglion7.05
Uterus40.4
UterusCorpus3.4
WholeBlood300.25
Wholebrain4.05
colon65.65
pineal_day7.08
pineal_night13.06
retina47.95
small_intestine120.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P166527
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.7 ± 1.02
Basal Forebrain2.3 ± 0.4
Basal Part of Pons1.85 ± 0.38
Cerebellar Cortex1.95 ± 0.65
Cerebellar Nuclei2.57 ± 0.89
Claustrum3.04 ± 0.67
Epithalamus2.13 ± 0.63
Frontal Lobe2.17 ± 0.84
Globus Pallidus3.45 ± 0.54
Hypothalamus1.96 ± 0.68
Insula2.49 ± 1.26
Limbic Lobe2.18 ± 0.79
Mesencephalon2.54 ± 0.81
Myelencephalon2.33 ± 0.67
Occipital Lobe2.23 ± 0.5
Parietal Lobe2.29 ± 0.76
Pontine Tegmentum2.33 ± 0.78
Striatum2.55 ± 0.66
Subthalamus2.54 ± 0.97
Temporal Lobe2.13 ± 0.62
Thalamus2.46 ± 0.78
White Matter3.11 ± 1.04
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfaip3CBCerebellum0.67
1.09
Tnfaip3CTXCerebral cortex0.65
0.46
Tnfaip3HIPHippocampal region1.44
1.02
Tnfaip3HPFHippocampal formation1.44
0.86
Tnfaip3HYHypothalamus0.47
0.39
Tnfaip3LSXLateral septal complex0.4
0.4
Tnfaip3MBMidbrain0.89
0.62
Tnfaip3MYMedulla0.55
0.66
Tnfaip3OLFOlfactory bulb1.19
0.79
Tnfaip3PPons0.64
0.78
Tnfaip3PALPallidum0.86
0.68
Tnfaip3RHPRetrohippocampal region1.4
0.66
Tnfaip3sAMYStriatum-like amygdalar nuclei0.63
0.65
Tnfaip3STRStriatum0.72
0.69
Tnfaip3STRdStriatum dorsal region0.55
0.53
Tnfaip3STRvStriatum ventral region0.89
0.68
Tnfaip3THThalamus0.67
0.46
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
TNAP3_HUMAN_2 15 2 16 AEQVLPQALYLSNMR PRIDE
TNAP3_HUMAN_421 19 421 439 LNSKPGPEGLPGMALGASR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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