AutismKB 2.0

Annotation Detail for TNNT2


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Basic Information Top
Gene Symbol:TNNT2 ( CMH2,CMPD2,LVNC6,MGC3889,RCM3,TnTC,cTnT )
Gene Full Name: troponin T type 2 (cardiac)
Band: 1q32.1
Quick LinksEntrez ID:7139; OMIM: 191045; Uniprot ID:TNNT2_HUMAN; ENSEMBL ID: ENSG00000118194; HGNC ID: 11949
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus55 / 56401297
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult40 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal121 / 336030736
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye3 / 21105414
heart142 / 896261584
intestine2 / 2344728
kidney4 / 21177718
larynx2 / 2414582
liver2 / 2077439
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215389_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13
Adipocyte15.55
AdrenalCortex19.75
Adrenalgland13.1
Amygdala11.65
Appendix21.95
AtrioventricularNode16.95
BDCA4+_DentriticCells10.35
Bonemarrow16.75
BronchialEpithelialCells12.7
CD105+_Endothelial13.4
CD14+_Monocytes14.85
CD19+_BCells(neg._sel.)13.7
CD33+_Myeloid16.9
CD34+15.4
CD4+_Tcells13.35
CD56+_NKCells15.2
CD71+_EarlyErythroid13.85
CD8+_Tcells10.1
CardiacMyocytes29.05
Caudatenucleus12.8
Cerebellum11.65
CerebellumPeduncles21.05
CiliaryGanglion19.6
CingulateCortex22.85
Colorectaladenocarcinoma14.1
DorsalRootGanglion15.65
FetalThyroid15.8
Fetalbrain13.55
Fetalliver13.9
Fetallung10.4
GlobusPallidus11.5
Heart7272.8
Hypothalamus14.8
Kidney14.6
Leukemia_chronicMyelogenousK-56212.55
Leukemia_promyelocytic-HL-6012.55
Leukemialymphoblastic(MOLT-4)10.4
Liver22.5
Lung14.95
Lymphnode11.25
Lymphoma_burkitts(Daudi)19.65
Lymphoma_burkitts(Raji)21.05
MedullaOblongata12.9
OccipitalLobe12.65
OlfactoryBulb10.75
Ovary12.35
Pancreas12.55
PancreaticIslet15.35
ParietalLobe16.75
Pituitary16.75
Placenta13.35
Pons14.65
PrefrontalCortex24.45
Prostate14
Salivarygland11.85
SkeletalMuscle26.05
Skin19.85
SmoothMuscle15.8
Spinalcord15.15
SubthalamicNucleus14.15
SuperiorCervicalGanglion24.85
TemporalLobe14.95
Testis11.6
TestisGermCell11.25
TestisIntersitial12.75
TestisLeydigCell14.65
TestisSeminiferousTubule12.25
Thalamus14.95
Thymus9.9
Thyroid12.5
Tongue20.25
Tonsil14.1
Trachea11.65
TrigeminalGanglion17.85
Uterus9.65
UterusCorpus18.15
WholeBlood14.35
Wholebrain10.3
colon12.9
pineal_day14.86
pineal_night14.1
retina16.675
small_intestine12.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P257022
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.84 ± 0.93
Basal Forebrain4.18 ± 0.3
Basal Part of Pons4.63 ± 1.26
Cerebellar Cortex4.12 ± 0.74
Cerebellar Nuclei4.36 ± 0.69
Claustrum5.52 ± 1.05
Epithalamus4.02 ± 0.91
Frontal Lobe5.68 ± 0.84
Globus Pallidus3.26 ± 1.23
Hypothalamus4.58 ± 0.68
Insula5.14 ± 0.75
Limbic Lobe4.9 ± 1.75
Mesencephalon4.92 ± 0.78
Myelencephalon4.63 ± 0.71
Occipital Lobe3.62 ± 1.31
Parietal Lobe5.98 ± 0.69
Pontine Tegmentum4.85 ± 1.21
Striatum3.14 ± 1.48
Subthalamus4.49 ± 0.75
Temporal Lobe4.84 ± 1.03
Thalamus4.37 ± 0.86
White Matter3.88 ± 1.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnnt2CBCerebellum0.57
0.98
Tnnt2CTXCerebral cortex0.62
0.57
Tnnt2HIPHippocampal region0.41
0.76
Tnnt2HPFHippocampal formation0.34
0.63
Tnnt2HYHypothalamus0.06
0.04
Tnnt2LSXLateral septal complex0.03
0
Tnnt2MBMidbrain0.18
0.29
Tnnt2MYMedulla4.19
5.81
Tnnt2OLFOlfactory bulb0.83
2.36
Tnnt2PPons0.39
0.55
Tnnt2PALPallidum0.1
0.1
Tnnt2RHPRetrohippocampal region0.18
0.36
Tnnt2sAMYStriatum-like amygdalar nuclei0.23
0.24
Tnnt2STRStriatum0.2
0.16
Tnnt2STRdStriatum dorsal region0.22
0.16
Tnnt2STRvStriatum ventral region0.15
0.1
Tnnt2THThalamus0.28
0.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
TNNT2_HUMAN_108 16 108 123 DLNELQALIEAHFENR PRIDE
TNNT2_HUMAN_187 14 187 200 ALSNMMHFGGYIQK PRIDE
TNNT2_HUMAN_228 13 228 240 VLAIDHLNEDQLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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