AutismKB 2.0

Annotation Detail for TNS1


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Basic Information Top
Gene Symbol:TNS1 ( DKFZp586K0617,MGC88584,MST091,MST122,MST127,MSTP122,MSTP127,MXRA6,TNS )
Gene Full Name: tensin 1
Band: 2q35
Quick LinksEntrez ID:7145; OMIM: 600076; Uniprot ID:TENS1_HUMAN; ENSEMBL ID: ENSG00000079308; HGNC ID: 11973
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus45 / 56401279
neonate1 / 3109732
infant1 / 2362042
juvenile1 / 5555617
adult226 / 1939121116
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor19 / 114246166
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma8 / 10688374
head and neck tumor9 / 13630266
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia11 / 97250113
normal259 / 336030777
ovarian tumor10 / 76682130
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor15 / 124949120
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone15 / 71655209
bone marrow0 / 488010 
brain41 / 110098937
cervix0 / 481710 
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye25 / 211054118
heart10 / 89626111
intestine31 / 234472132
kidney9 / 21177742
larynx2 / 2414582
liver6 / 20774328
lung45 / 336974133
lymph0 / 442700 
lymph node0 / 916100 
mammary gland19 / 153271123
mouth4 / 6705259
muscle15 / 107715139
nerve2 / 15768126
ovary11 / 102051107
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta23 / 28082581
prostate24 / 189345126
salivary gland0 / 201550 
skin20 / 21057494
spleen7 / 53952129
stomach8 / 9661982
testis14 / 33044242
thymus5 / 8113161
thyroid9 / 47473189
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus20 / 23287885
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218863_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts41.35
Adipocyte33.95
AdrenalCortex50.4
Adrenalgland29.65
Amygdala25.95
Appendix36.3
AtrioventricularNode61.8
BDCA4+_DentriticCells29.45
Bonemarrow35
BronchialEpithelialCells32.85
CD105+_Endothelial33.95
CD14+_Monocytes34.35
CD19+_BCells(neg._sel.)36
CD33+_Myeloid30.1
CD34+42.15
CD4+_Tcells35.7
CD56+_NKCells35.25
CD71+_EarlyErythroid447.95
CD8+_Tcells31.25
CardiacMyocytes48.75
Caudatenucleus32.1
Cerebellum28.15
CerebellumPeduncles39.95
CiliaryGanglion54.95
CingulateCortex37.45
Colorectaladenocarcinoma34.75
DorsalRootGanglion36
FetalThyroid32.55
Fetalbrain34.9
Fetalliver33.25
Fetallung22.55
GlobusPallidus36.35
Heart45.2
Hypothalamus36.45
Kidney29.3
Leukemia_chronicMyelogenousK-56231.6
Leukemia_promyelocytic-HL-6029.25
Leukemialymphoblastic(MOLT-4)27
Liver51.35
Lung30
Lymphnode29.75
Lymphoma_burkitts(Daudi)47.05
Lymphoma_burkitts(Raji)49.7
MedullaOblongata30.65
OccipitalLobe31.05
OlfactoryBulb33.65
Ovary26.15
Pancreas26.85
PancreaticIslet42
ParietalLobe39.4
Pituitary39.8
Placenta36.9
Pons40.85
PrefrontalCortex41.6
Prostate30.75
Salivarygland28.2
SkeletalMuscle56.7
Skin45.35
SmoothMuscle26.1
Spinalcord50.5
SubthalamicNucleus46.4
SuperiorCervicalGanglion60.6
TemporalLobe33.75
Testis28.6
TestisGermCell33.2
TestisIntersitial29.7
TestisLeydigCell39.9
TestisSeminiferousTubule55.7
Thalamus65.8
Thymus24.05
Thyroid26.1
Tongue36.85
Tonsil35.05
Trachea29.05
TrigeminalGanglion42.2
Uterus22.5
UterusCorpus46.1
WholeBlood20.65
Wholebrain26.4
colon16.7
pineal_day70.46
pineal_night65.64
retina45.925
small_intestine15.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P105733
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.93 ± 0.94
Basal Forebrain4.65 ± 0.84
Basal Part of Pons4.23 ± 1.02
Cerebellar Cortex3.51 ± 0.64
Cerebellar Nuclei5.67 ± 0.64
Claustrum4.66 ± 0.88
Epithalamus4.52 ± 0.57
Frontal Lobe4.15 ± 0.9
Globus Pallidus6.59 ± 0.57
Hypothalamus4.01 ± 1.08
Insula3.68 ± 0.85
Limbic Lobe3.94 ± 1
Mesencephalon4.8 ± 0.91
Myelencephalon4.31 ± 0.76
Occipital Lobe4.47 ± 0.82
Parietal Lobe4.25 ± 0.86
Pontine Tegmentum4.4 ± 0.9
Striatum5.12 ± 0.76
Subthalamus4.81 ± 0.3
Temporal Lobe3.93 ± 0.81
Thalamus4.41 ± 0.76
White Matter6.78 ± 0.61
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00476310 20 1621 1640 ATSETLAADPTPAATIVHFK Peptide Atlas
TENS1_HUMAN_1105 12 1105 1116 TPTQPLLESGFR PRIDE
TENS1_HUMAN_1117 13 1117 1129 SGSLGQPSPSAQR PRIDE
TENS1_HUMAN_1440 11 1440 1450 YSMPDNSPETR PRIDE
TENS1_HUMAN_1479 10 1479 1488 DQEPGAFIIR PRIDE
TENS1_HUMAN_1503 13 1503 1515 VSSPPPTIMQQNK PRIDE
TENS1_HUMAN_154 10 154 163 IVPIGQPSQR PRIDE
TENS1_HUMAN_164 15 164 178 RYVHYFSGLLSGSIK PRIDE
TENS1_HUMAN_1641 13 1641 1653 VSAQGITLTDNQR PRIDE
TENS1_HUMAN_300 11 300 310 VEFVFSYGPEK PRIDE
TENS1_HUMAN_311 25 311 335 IQGMEHLENGPSVSVDYNTSDPLIR PRIDE
TENS1_HUMAN_347 22 347 368 DDGMEEVVGHTQGPLDGSLYAK PRIDE
TENS1_HUMAN_38 11 38 48 SNLREVAQMLK PRIDE
TENS1_HUMAN_418 20 418 437 TDEPVPGASSATAALSPQEK PRIDE
TENS1_HUMAN_443 9 443 451 LLSGFGLER PRIDE
TENS1_HUMAN_454 11 454 464 QGAMYHTQHLR PRIDE
TENS1_HUMAN_454 25 454 478 QGAMYHTQHLRSRPAGGSAVPSSGR PRIDE
TENS1_HUMAN_465 14 465 478 SRPAGGSAVPSSGR PRIDE
TENS1_HUMAN_764 18 764 781 SGYIPSGHSLGTPEPAPR PRIDE
TENS1_HUMAN_860 16 860 875 TPEEEPLNLEGLVAHR PRIDE
TENS1_HUMAN_951 20 951 970 EAFEEMEGTSPSSPPPSGVR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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