AutismKB 2.0

Annotation Detail for TOP2B


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Basic Information Top
Gene Symbol:TOP2B ( TOPIIB,top2beta )
Gene Full Name: topoisomerase (DNA) II beta 180kDa
Band: 3p24.2
Quick LinksEntrez ID:7155; OMIM: 126431; Uniprot ID:TOP2B_HUMAN; ENSEMBL ID: ENSG00000077097; HGNC ID: 11990
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body20 / 70761282
blastocyst10 / 62319160
fetus117 / 564012207
neonate3 / 3109796
infant0 / 236200 
juvenile6 / 55556107
adult267 / 1939121137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma8 / 8282396
colorectal tumor13 / 114246113
esophageal tumor2 / 17290115
gastrointestinal tumor15 / 119369125
germ cell tumor101 / 263845382
glioma7 / 10688365
head and neck tumor15 / 136302110
kidney tumor4 / 6895958
leukemia22 / 95842229
liver tumor12 / 96359124
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia9 / 9725092
normal428 / 3360307127
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer8 / 10268077
retinoblastoma4 / 4635686
skin tumor11 / 12494988
soft tissue/muscle tissue tumor26 / 125191207
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites4 / 4001599
bladder10 / 29757336
blood8 / 12347864
bone7 / 7165597
bone marrow15 / 48801307
brain144 / 1100989130
cervix2 / 4817141
connective tissue22 / 149255147
ear1 / 1621261
embryonic tissue45 / 215722208
esophagus2 / 2020998
eye25 / 211054118
heart23 / 89626256
intestine45 / 234472191
kidney18 / 21177784
larynx1 / 2414541
liver22 / 207743105
lung40 / 336974118
lymph4 / 4427090
lymph node16 / 91610174
mammary gland15 / 15327197
mouth9 / 67052134
muscle5 / 10771546
nerve0 / 157680 
ovary3 / 10205129
pancreas15 / 21481269
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta31 / 280825110
prostate14 / 18934573
salivary gland1 / 2015549
skin15 / 21057471
spleen6 / 53952111
stomach16 / 96619165
testis48 / 330442145
thymus9 / 81131110
thyroid11 / 47473231
tonsil1 / 1699958
trachea9 / 52413171
umbilical cord1 / 1368073
uterus41 / 232878176
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211987_at
Cell line Expression level Expression bar
721_B_lymphoblasts129.6
Adipocyte8.6
AdrenalCortex8.45
Adrenalgland5.05
Amygdala70.85
Appendix8.35
AtrioventricularNode4.85
BDCA4+_DentriticCells114.15
Bonemarrow5.6
BronchialEpithelialCells18.45
CD105+_Endothelial99.8
CD14+_Monocytes50.25
CD19+_BCells(neg._sel.)58.4
CD33+_Myeloid74.8
CD34+269.4
CD4+_Tcells91.95
CD56+_NKCells145.2
CD71+_EarlyErythroid7.6
CD8+_Tcells139.05
CardiacMyocytes12.8
Caudatenucleus23.25
Cerebellum10.4
CerebellumPeduncles17.25
CiliaryGanglion4.5
CingulateCortex20.65
Colorectaladenocarcinoma16.4
DorsalRootGanglion4.8
FetalThyroid28.3
Fetalbrain127.65
Fetalliver12.95
Fetallung34.65
GlobusPallidus9.25
Heart6.85
Hypothalamus62.95
Kidney4.4
Leukemia_chronicMyelogenousK-56234.95
Leukemia_promyelocytic-HL-6054.05
Leukemialymphoblastic(MOLT-4)134.4
Liver7.05
Lung6
Lymphnode44.15
Lymphoma_burkitts(Daudi)57.5
Lymphoma_burkitts(Raji)36.4
MedullaOblongata23.75
OccipitalLobe42.05
OlfactoryBulb12.4
Ovary9.85
Pancreas9.95
PancreaticIslet14.7
ParietalLobe21.35
Pituitary31.65
Placenta7.25
Pons11.25
PrefrontalCortex64.3
Prostate18
Salivarygland12.4
SkeletalMuscle6.25
Skin6.85
SmoothMuscle38.15
Spinalcord32.35
SubthalamicNucleus16.55
SuperiorCervicalGanglion6.8
TemporalLobe11.4
Testis4.85
TestisGermCell9.25
TestisIntersitial6.8
TestisLeydigCell7.1
TestisSeminiferousTubule5.55
Thalamus15.3
Thymus28.55
Thyroid54.15
Tongue7.9
Tonsil27.95
Trachea7.45
TrigeminalGanglion5.75
Uterus83.35
UterusCorpus6.4
WholeBlood96.8
Wholebrain14.9
colon15.9
pineal_day110.3
pineal_night113.64
retina13.875
small_intestine9.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7694_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.57 ± 0.3
Basal Forebrain10.37 ± 0.35
Basal Part of Pons10.43 ± 0.18
Cerebellar Cortex10.41 ± 0.43
Cerebellar Nuclei10.17 ± 0.36
Claustrum10.86 ± 0.56
Epithalamus10.46 ± 0.43
Frontal Lobe10.1 ± 0.41
Globus Pallidus10.5 ± 0.28
Hypothalamus10.14 ± 0.41
Insula10.15 ± 0.37
Limbic Lobe10.47 ± 0.43
Mesencephalon10.34 ± 0.44
Myelencephalon10.32 ± 0.48
Occipital Lobe10.68 ± 0.52
Parietal Lobe10.35 ± 0.42
Pontine Tegmentum10.27 ± 0.49
Striatum10.27 ± 0.37
Subthalamus10.29 ± 0.26
Temporal Lobe10.24 ± 0.4
Thalamus10.18 ± 0.46
White Matter10.98 ± 0.56
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002601 11 193 203 FTVETACKEYK Peptide Atlas
TOP2B_HUMAN_1093 9 1093 1101 DLIQMLVQR PRIDE
TOP2B_HUMAN_1464 19 1464 1482 FDSNEEDSASVFSPSFGLK PRIDE
TOP2B_HUMAN_1516 17 1516 1532 VVEAVNSDSDSEFGIPK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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