AutismKB 2.0

Annotation Detail for TPBG


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Basic Information Top
Gene Symbol:TPBG ( 5T4,5T4AG,M6P1 )
Gene Full Name: trophoblast glycoprotein
Band: 6q14.1
Quick LinksEntrez ID:7162; OMIM: 190920; Uniprot ID:TPBG_HUMAN; ENSEMBL ID: ENSG00000146242; HGNC ID: 12004
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst12 / 62319192
fetus31 / 56401254
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor6 / 11936950
germ cell tumor30 / 263845113
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia4 / 9725041
normal134 / 336030739
ovarian tumor2 / 7668226
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer12 / 102680116
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain27 / 110098924
cervix1 / 4817120
connective tissue6 / 14925540
ear3 / 16212185
embryonic tissue27 / 215722125
esophagus1 / 2020949
eye10 / 21105447
heart5 / 8962655
intestine8 / 23447234
kidney6 / 21177728
larynx0 / 241450 
liver1 / 2077434
lung19 / 33697456
lymph4 / 4427090
lymph node0 / 916100 
mammary gland10 / 15327165
mouth3 / 6705244
muscle7 / 10771564
nerve0 / 157680 
ovary7 / 10205168
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta11 / 28082539
prostate19 / 189345100
salivary gland0 / 201550 
skin9 / 21057442
spleen1 / 5395218
stomach3 / 9661931
testis19 / 33044257
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus10 / 23287842
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203476_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte43.95
AdrenalCortex6.2
Adrenalgland5.05
Amygdala5.4
Appendix8.7
AtrioventricularNode4.8
BDCA4+_DentriticCells4.65
Bonemarrow4.2
BronchialEpithelialCells506.4
CD105+_Endothelial5.65
CD14+_Monocytes4.5
CD19+_BCells(neg._sel.)5.25
CD33+_Myeloid10.4
CD34+7.75
CD4+_Tcells4.7
CD56+_NKCells6.3
CD71+_EarlyErythroid3.95
CD8+_Tcells5.15
CardiacMyocytes96.6
Caudatenucleus92.75
Cerebellum3.4
CerebellumPeduncles4.85
CiliaryGanglion4.35
CingulateCortex6.35
Colorectaladenocarcinoma67.25
DorsalRootGanglion4.5
FetalThyroid14.5
Fetalbrain4.7
Fetalliver4
Fetallung5.55
GlobusPallidus4.45
Heart5.65
Hypothalamus7.9
Kidney4.95
Leukemia_chronicMyelogenousK-5625.25
Leukemia_promyelocytic-HL-604.3
Leukemialymphoblastic(MOLT-4)3.75
Liver5.6
Lung6.7
Lymphnode5.25
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)6
MedullaOblongata31.15
OccipitalLobe10.15
OlfactoryBulb4.65
Ovary4
Pancreas19.65
PancreaticIslet9.25
ParietalLobe6.5
Pituitary39.95
Placenta108.2
Pons9.8
PrefrontalCortex25.1
Prostate22.85
Salivarygland11.7
SkeletalMuscle6.8
Skin6.95
SmoothMuscle402.75
Spinalcord8.2
SubthalamicNucleus5.5
SuperiorCervicalGanglion6.7
TemporalLobe8.35
Testis6.75
TestisGermCell6.7
TestisIntersitial4.85
TestisLeydigCell5.75
TestisSeminiferousTubule4.35
Thalamus5.85
Thymus10.6
Thyroid44.8
Tongue15.7
Tonsil5.8
Trachea42.5
TrigeminalGanglion6.65
Uterus44.8
UterusCorpus32.1
WholeBlood5.8
Wholebrain31
colon12.2
pineal_day9.4
pineal_night17.58
retina15.175
small_intestine7.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1950_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.24 ± 0.94
Basal Forebrain3.49 ± 0.51
Basal Part of Pons3.87 ± 0.33
Cerebellar Cortex2.68 ± 0.62
Cerebellar Nuclei3.03 ± 0.56
Claustrum3.4 ± 0.57
Epithalamus2.98 ± 0.88
Frontal Lobe3.13 ± 0.7
Globus Pallidus3.2 ± 0.77
Hypothalamus3.07 ± 0.83
Insula2.79 ± 0.52
Limbic Lobe3.01 ± 0.85
Mesencephalon3.3 ± 0.85
Myelencephalon3.13 ± 0.84
Occipital Lobe2.97 ± 0.95
Parietal Lobe3.39 ± 0.76
Pontine Tegmentum3.02 ± 0.83
Striatum4.75 ± 0.64
Subthalamus2.97 ± 1.19
Temporal Lobe2.89 ± 0.73
Thalamus2.92 ± 0.81
White Matter2.84 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TpbgCBCerebellum19.37
23.17
TpbgCTXCerebral cortex47.36
36.42
TpbgHIPHippocampal region6.1
5.95
TpbgHPFHippocampal formation18.77
17.74
TpbgHYHypothalamus20.02
14.05
TpbgLSXLateral septal complex7.09
3.97
TpbgMBMidbrain34.25
35.15
TpbgMYMedulla36.25
37.22
TpbgOLFOlfactory bulb52.51
51.73
TpbgPPons26.5
27.97
TpbgPALPallidum24.6
18.34
TpbgRHPRetrohippocampal region35.73
30.33
TpbgsAMYStriatum-like amygdalar nuclei38.21
26.29
TpbgSTRStriatum36.2
23.71
TpbgSTRdStriatum dorsal region32.5
21.52
TpbgSTRvStriatum ventral region57.29
34.75
TpbgTHThalamus10.44
9.79
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00500345 11 135 145 AGAFEHLPSLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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