AutismKB 2.0

Annotation Detail for TPI1


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Basic Information Top
Gene Symbol:TPI1 ( MGC88108,TPI )
Gene Full Name: triosephosphate isomerase 1
Band: 12p13.31
Quick LinksEntrez ID:7167; OMIM: 190450; Uniprot ID:TPIS_HUMAN; ENSEMBL ID: ENSG00000111669; HGNC ID: 12009
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body44 / 70761621
blastocyst34 / 62319545
fetus137 / 564012242
neonate3 / 3109796
infant9 / 23620381
juvenile18 / 55556323
adult1046 / 1939121539
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor28 / 127942188
bladder carcinoma6 / 17475343
breast (mammary gland) tumor54 / 94178573
cervical tumor34 / 34366989
chondrosarcoma50 / 82823603
colorectal tumor86 / 114246752
esophageal tumor6 / 17290347
gastrointestinal tumor90 / 119369753
germ cell tumor192 / 263845727
glioma142 / 1068831328
head and neck tumor79 / 136302579
kidney tumor99 / 689591435
leukemia63 / 95842657
liver tumor71 / 96359736
lung tumor144 / 1031271396
lymphoma93 / 717551296
non-neoplasia16 / 97250164
normal1443 / 3360307429
ovarian tumor71 / 76682925
pancreatic tumor119 / 1046161137
primitive neuroectodermal tumor of the CNS94 / 125680747
prostate cancer63 / 102680613
retinoblastoma48 / 463561035
skin tumor168 / 1249491344
soft tissue/muscle tissue tumor120 / 125191958
uterine tumor80 / 90257886
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland35 / 331971054
ascites23 / 40015574
bladder16 / 29757537
blood84 / 123478680
bone47 / 71655655
bone marrow136 / 488012786
brain401 / 1100989364
cervix35 / 48171726
connective tissue28 / 149255187
ear0 / 162120 
embryonic tissue146 / 215722676
esophagus6 / 20209296
eye138 / 211054653
heart45 / 89626502
intestine125 / 234472533
kidney133 / 211777628
larynx15 / 24145621
liver127 / 207743611
lung237 / 336974703
lymph75 / 442701694
lymph node24 / 91610261
mammary gland70 / 153271456
mouth18 / 67052268
muscle112 / 1077151039
nerve5 / 15768317
ovary92 / 102051901
pancreas130 / 214812605
parathyroid14 / 20539681
pharynx162 / 413283919
pituitary gland6 / 16585361
placenta112 / 280825398
prostate102 / 189345538
salivary gland47 / 201552331
skin201 / 210574954
spleen6 / 53952111
stomach66 / 96619683
testis124 / 330442375
thymus1 / 8113112
thyroid4 / 4747384
tonsil23 / 169991353
trachea1 / 5241319
umbilical cord5 / 13680365
uterus201 / 232878863
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200822_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts3556.45
Adipocyte653.7
AdrenalCortex692.15
Adrenalgland1001
Amygdala1196.8
Appendix253.7
AtrioventricularNode145.35
BDCA4+_DentriticCells684.65
Bonemarrow762.9
BronchialEpithelialCells2270
CD105+_Endothelial1015.45
CD14+_Monocytes1329.5
CD19+_BCells(neg._sel.)762.9
CD33+_Myeloid1418
CD34+1616.35
CD4+_Tcells518.85
CD56+_NKCells1035.8
CD71+_EarlyErythroid377.1
CD8+_Tcells411.2
CardiacMyocytes1807.45
Caudatenucleus884.45
Cerebellum1473.05
CerebellumPeduncles1401.65
CiliaryGanglion255.8
CingulateCortex1056.95
Colorectaladenocarcinoma1387.6
DorsalRootGanglion347.15
FetalThyroid759.7
Fetalbrain847.65
Fetalliver409.35
Fetallung939.45
GlobusPallidus701.7
Heart2547.9
Hypothalamus1494.25
Kidney1273.7
Leukemia_chronicMyelogenousK-562915.65
Leukemia_promyelocytic-HL-601996
Leukemialymphoblastic(MOLT-4)1634.55
Liver1172.9
Lung791.05
Lymphnode472.55
Lymphoma_burkitts(Daudi)2166.8
Lymphoma_burkitts(Raji)3061.05
MedullaOblongata846.35
OccipitalLobe1072.3
OlfactoryBulb453.75
Ovary591.7
Pancreas691.2
PancreaticIslet923
ParietalLobe1104.9
Pituitary528.75
Placenta997.65
Pons692.15
PrefrontalCortex1810.1
Prostate764.95
Salivarygland368
SkeletalMuscle795.2
Skin302.45
SmoothMuscle2689.05
Spinalcord758.95
SubthalamicNucleus1178.3
SuperiorCervicalGanglion220.3
TemporalLobe1296.7
Testis896.8
TestisGermCell726.4
TestisIntersitial515.05
TestisLeydigCell439.6
TestisSeminiferousTubule375.3
Thalamus2254.45
Thymus719.85
Thyroid940.8
Tongue1017.15
Tonsil742.45
Trachea499.6
TrigeminalGanglion327.15
Uterus289.9
UterusCorpus630.45
WholeBlood828.9
Wholebrain1998.85
colon727.35
pineal_day1297.22
pineal_night1254.12
retina1397.7
small_intestine915.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P53546
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.43 ± 0.33
Basal Forebrain8.35 ± 0.26
Basal Part of Pons9.01 ± 0.18
Cerebellar Cortex8.89 ± 0.11
Cerebellar Nuclei8.9 ± 0.4
Claustrum8.57 ± 0.28
Epithalamus8.06 ± 0.36
Frontal Lobe8.76 ± 0.28
Globus Pallidus8.02 ± 0.16
Hypothalamus8.36 ± 0.41
Insula8.77 ± 0.14
Limbic Lobe8.56 ± 0.34
Mesencephalon8.54 ± 0.32
Myelencephalon8.54 ± 0.39
Occipital Lobe8.29 ± 0.4
Parietal Lobe8.7 ± 0.31
Pontine Tegmentum8.53 ± 0.31
Striatum8.03 ± 0.36
Subthalamus9.01 ± 0.31
Temporal Lobe8.74 ± 0.22
Thalamus8.65 ± 0.27
White Matter7.29 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tpi1PPons0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000216 17 163 179 ACIGEKLDEREAGITEK Peptide Atlas
TPIS_HUMAN_0 0 0 0 DCGATWVVLGHSER PRIDE
TPIS_HUMAN_0 0 0 0 HVFGESDELIGQK PRIDE
TPIS_HUMAN_0 0 0 0 IAVAAQNCYK PRIDE
TPIS_HUMAN_0 0 0 0 IIYGGSVTGATCK PRIDE
TPIS_HUMAN_0 0 0 0 KFFVGGNWK PRIDE
TPIS_HUMAN_0 0 0 0 KQSLGELIGTLNAAK PRIDE
TPIS_HUMAN_0 0 0 0 QSLGELIGTLNAAK PRIDE
TPIS_HUMAN_0 0 0 0 SNVSDAVAQSTR PRIDE
TPIS_HUMAN_0 0 0 0 TATPQQAQEVHEK PRIDE
TPIS_HUMAN_0 0 0 0 VIADNVKDWSK PRIDE
TPIS_HUMAN_0 0 0 0 VPADTEVVCAPPTAYIDFAR PRIDE
TPIS_HUMAN_0 0 0 0 VTNGAFTGEISPGMIK PRIDE
TPIS_HUMAN_0 0 0 0 VVLAYEPVWAIGTGK PRIDE
TPIS_HUMAN_100 13 100 112 HVFGESDELIGQK PRIDE
TPIS_HUMAN_100 14 100 113 RHVFGESDELIGQK PRIDE
TPIS_HUMAN_100 31 100 130 HVFGESDELIGQKVAHALAEGLGVIACIGEK PRIDE
TPIS_HUMAN_101 13 101 113 HVFGESDELIGQK PRIDE
TPIS_HUMAN_113 18 113 130 VAHALAEGLGVIACIGEK PRIDE
TPIS_HUMAN_113 22 113 134 VAHALAEGLGVIACIGEKLDER PRIDE
TPIS_HUMAN_113 29 113 141 VAHALAEGLGVIACIGEKLDEREAGITEK PRIDE
TPIS_HUMAN_114 18 114 131 VAHALAEGLGVIACIGEK PRIDE
TPIS_HUMAN_114 22 114 135 VAHALAEGLGVIACIGEKLDER PRIDE
TPIS_HUMAN_131 11 131 141 LDEREAGITEK PRIDE
TPIS_HUMAN_135 14 135 148 EAGITEKVVFEQTK PRIDE
TPIS_HUMAN_142 18 142 159 VVFEQTKVIADNVKDWSK PRIDE
TPIS_HUMAN_143 7 143 149 VVFEQTK PRIDE
TPIS_HUMAN_149 11 149 159 VIADNVKDWSK PRIDE
TPIS_HUMAN_149 26 149 174 VIADNVKDWSKVVLAYEPVWAIGTGK PRIDE
TPIS_HUMAN_150 7 150 156 VIADNVK PRIDE
TPIS_HUMAN_160 15 160 174 VVLAYEPVWAIGTGK PRIDE
TPIS_HUMAN_161 15 161 175 VVLAYEPVWAIGTGK PRIDE
TPIS_HUMAN_175 13 175 187 TATPQQAQEVHEK PRIDE
TPIS_HUMAN_175 15 175 189 TATPQQAQEVHEKLR PRIDE
TPIS_HUMAN_176 13 176 188 TATPQQAQEVHEK PRIDE
TPIS_HUMAN_18 15 18 32 KQSLGELIGTLNAAK PRIDE
TPIS_HUMAN_18 35 18 52 KQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFAR PRIDE
TPIS_HUMAN_19 14 19 32 QSLGELIGTLNAAK PRIDE
TPIS_HUMAN_19 15 19 33 KQSLGELIGTLNAAK PRIDE
TPIS_HUMAN_190 16 190 205 GWLKSNVSDAVAQSTR PRIDE
TPIS_HUMAN_191 16 191 206 GWLKSNVSDAVAQSTR PRIDE
TPIS_HUMAN_192 14 192 205 LKSNVSDAVAQSTR PRIDE
TPIS_HUMAN_193 13 193 205 KSNVSDAVAQSTR PRIDE
TPIS_HUMAN_194 12 194 205 SNVSDAVAQSTR PRIDE
TPIS_HUMAN_195 12 195 206 SNVSDAVAQSTR PRIDE
TPIS_HUMAN_195 25 195 219 SNVSDAVAQSTRIIYGGSVTGATCK PRIDE
TPIS_HUMAN_20 14 20 33 QSLGELIGTLNAAK PRIDE
TPIS_HUMAN_206 13 206 218 IIYGGSVTGATCK PRIDE
TPIS_HUMAN_207 13 207 219 IIYGGSVTGATCK PRIDE
TPIS_HUMAN_219 29 219 247 ELASQPDVDGFLVGGASLKPEFVDIINAK PRIDE
TPIS_HUMAN_219 30 219 248 ELASQPDVDGFLVGGASLKPEFVDIINAKQ PRIDE
TPIS_HUMAN_220 29 220 248 ELASQPDVDGFLVGGASLKPEFVDIINAK PRIDE
TPIS_HUMAN_33 20 33 52 VPADTEVVCAPPTAYIDFAR PRIDE
TPIS_HUMAN_34 20 34 53 VPADTEVVCAPPTAYIDFAR PRIDE
TPIS_HUMAN_5 9 5 13 KFFVGGNWK PRIDE
TPIS_HUMAN_53 13 53 65 QKLDPKIAVAAQN PRIDE
TPIS_HUMAN_53 15 53 67 QKLDPKIAVAAQNCY PRIDE
TPIS_HUMAN_59 10 59 68 IAVAAQNCYK PRIDE
TPIS_HUMAN_6 8 6 13 FFVGGNWK PRIDE
TPIS_HUMAN_60 10 60 69 IAVAAQNCYK PRIDE
TPIS_HUMAN_69 16 69 84 VTNGAFTGEISPGMIK PRIDE
TPIS_HUMAN_69 30 69 98 VTNGAFTGEISPGMIKDCGATWVVLGHSER PRIDE
TPIS_HUMAN_7 8 7 14 FFVGGNWK PRIDE
TPIS_HUMAN_70 16 70 85 VTNGAFTGEISPGMIK PRIDE
TPIS_HUMAN_70 30 70 99 VTNGAFTGEISPGMIKDCGATWVVLGHSER PRIDE
TPIS_HUMAN_85 14 85 98 DCGATWVVLGHSER PRIDE
TPIS_HUMAN_85 15 85 99 DCGATWVVLGHSERR PRIDE
TPIS_HUMAN_86 14 86 99 DCGATWVVLGHSER PRIDE
TPIS_HUMAN_99 14 99 112 RHVFGESDELIGQK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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