AutismKB 2.0

Annotation Detail for TPM1


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Basic Information Top
Gene Symbol:TPM1 ( C15orf13,CMD1Y,HTM-alpha,TMSA )
Gene Full Name: tropomyosin 1 (alpha)
Band: 15q22.2
Quick LinksEntrez ID:7168; OMIM: 191010; Uniprot ID:TPM1_HUMAN; ENSEMBL ID: ENSG00000140416; HGNC ID: 12010
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body137 / 707611936
blastocyst54 / 62319866
fetus230 / 564012407
neonate27 / 31097868
infant1 / 2362042
juvenile19 / 55556341
adult709 / 1939121365
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor14 / 94178148
cervical tumor4 / 34366116
chondrosarcoma19 / 82823229
colorectal tumor26 / 114246227
esophageal tumor0 / 172900 
gastrointestinal tumor48 / 119369402
germ cell tumor72 / 263845272
glioma13 / 106883121
head and neck tumor24 / 136302176
kidney tumor39 / 68959565
leukemia11 / 95842114
liver tumor71 / 96359736
lung tumor7 / 10312767
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal1343 / 3360307399
ovarian tumor14 / 76682182
pancreatic tumor24 / 104616229
primitive neuroectodermal tumor of the CNS31 / 125680246
prostate cancer16 / 102680155
retinoblastoma2 / 4635643
skin tumor1 / 1249498
soft tissue/muscle tissue tumor20 / 125191159
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland3 / 3319790
ascites2 / 4001549
bladder8 / 29757268
blood13 / 123478105
bone36 / 71655502
bone marrow7 / 48801143
brain132 / 1100989119
cervix9 / 48171186
connective tissue10 / 14925566
ear8 / 16212493
embryonic tissue250 / 2157221158
esophagus7 / 20209346
eye80 / 211054379
heart269 / 896263001
intestine86 / 234472366
kidney70 / 211777330
larynx1 / 2414541
liver92 / 207743442
lung55 / 336974163
lymph0 / 442700 
lymph node11 / 91610120
mammary gland35 / 153271228
mouth11 / 67052164
muscle226 / 1077152098
nerve4 / 15768253
ovary14 / 102051137
pancreas44 / 214812204
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland3 / 16585180
placenta102 / 280825363
prostate71 / 189345374
salivary gland3 / 20155148
skin38 / 210574180
spleen5 / 5395292
stomach54 / 96619558
testis35 / 330442105
thymus2 / 8113124
thyroid15 / 47473315
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord27 / 136801973
uterus84 / 232878360
vascular53 / 517801023
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206117_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.35
Adipocyte4.45
AdrenalCortex4.8
Adrenalgland3.8
Amygdala4.7
Appendix4.6
AtrioventricularNode3.65
BDCA4+_DentriticCells4.75
Bonemarrow4.5
BronchialEpithelialCells4.35
CD105+_Endothelial4.5
CD14+_Monocytes4.75
CD19+_BCells(neg._sel.)4.7
CD33+_Myeloid5.65
CD34+5.6
CD4+_Tcells4.75
CD56+_NKCells5.2
CD71+_EarlyErythroid4.2
CD8+_Tcells4.2
CardiacMyocytes6.7
Caudatenucleus4
Cerebellum3.65
CerebellumPeduncles5.15
CiliaryGanglion3.25
CingulateCortex4.6
Colorectaladenocarcinoma4.45
DorsalRootGanglion3.55
FetalThyroid148.5
Fetalbrain4.4
Fetalliver3.9
Fetallung3.7
GlobusPallidus3.25
Heart4986.35
Hypothalamus4.85
Kidney3.75
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.55
Liver6
Lung4.9
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.45
MedullaOblongata4.05
OccipitalLobe4
OlfactoryBulb3.55
Ovary2.95
Pancreas3.6
PancreaticIslet4.8
ParietalLobe4.85
Pituitary5.2
Placenta4.55
Pons4.25
PrefrontalCortex5.5
Prostate10.25
Salivarygland3.65
SkeletalMuscle1316.3
Skin3.5
SmoothMuscle11.35
Spinalcord4.8
SubthalamicNucleus4.1
SuperiorCervicalGanglion5.25
TemporalLobe4.1
Testis9.1
TestisGermCell3.65
TestisIntersitial3.75
TestisLeydigCell4.45
TestisSeminiferousTubule3.85
Thalamus4.6
Thymus3.5
Thyroid484
Tongue1761.5
Tonsil4.35
Trachea3.75
TrigeminalGanglion4.45
Uterus10.85
UterusCorpus4.1
WholeBlood4.85
Wholebrain3.8
colon6.85
pineal_day11.12
pineal_night6
retina144.75
small_intestine5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14754_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.51 ± 0.45
Basal Forebrain4.25 ± 0.37
Basal Part of Pons3.99 ± 0.63
Cerebellar Cortex4.38 ± 0.38
Cerebellar Nuclei3.68 ± 0.52
Claustrum3.81 ± 0.72
Epithalamus5.06 ± 0.47
Frontal Lobe4.41 ± 0.44
Globus Pallidus5.69 ± 0.34
Hypothalamus4.28 ± 0.49
Insula4.34 ± 0.27
Limbic Lobe4.3 ± 0.56
Mesencephalon4.5 ± 0.58
Myelencephalon4.45 ± 0.52
Occipital Lobe4.12 ± 0.72
Parietal Lobe4.33 ± 0.43
Pontine Tegmentum4.59 ± 0.49
Striatum4.8 ± 0.45
Subthalamus4.54 ± 0.49
Temporal Lobe4.63 ± 0.42
Thalamus4.73 ± 0.41
White Matter3.62 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tpm1CBCerebellum44.39
79.55
Tpm1CTXCerebral cortex100
100
Tpm1HIPHippocampal region100
100
Tpm1HPFHippocampal formation100
100
Tpm1HYHypothalamus45.87
44.78
Tpm1LSXLateral septal complex100
100
Tpm1MBMidbrain58.77
65.7
Tpm1MYMedulla76.44
100
Tpm1OLFOlfactory bulb100
100
Tpm1PPons59.18
78.68
Tpm1PALPallidum52.87
61.72
Tpm1RHPRetrohippocampal region100
100
Tpm1sAMYStriatum-like amygdalar nuclei95.51
89.55
Tpm1STRStriatum100
100
Tpm1STRdStriatum dorsal region100
100
Tpm1STRvStriatum ventral region100
100
Tpm1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00035015 10 92 101 IQLVEEELDR Peptide Atlas
TPM1_HUMAN_0 0 0 0 IQLVEEELDR PRIDE
TPM1_HUMAN_0 0 0 0 IQLVEEELDRAQER PRIDE
TPM1_HUMAN_0 0 0 0 LATALQKLEEAEK PRIDE
TPM1_HUMAN_0 0 0 0 LEEAEKAADESER PRIDE
TPM1_HUMAN_0 0 0 0 RIQLVEEELDRAQER PRIDE
TPM1_HUMAN_105 13 105 117 LATALQKLEEAEK PRIDE
TPM1_HUMAN_105 20 105 124 LATALQKLEEAEKAADESER PRIDE
TPM1_HUMAN_106 7 106 112 LATALQK PRIDE
TPM1_HUMAN_112 13 112 124 LEEAEKAADESER PRIDE
TPM1_HUMAN_112 16 112 127 LEEAEKAADESERGMK PRIDE
TPM1_HUMAN_113 13 113 125 LEEAEKAADESER PRIDE
TPM1_HUMAN_133 16 133 148 AQKDEEKMEIQEIQLK PRIDE
TPM1_HUMAN_140 9 140 148 MEIQEIQLK PRIDE
TPM1_HUMAN_141 9 141 149 MEIQEIQLK PRIDE
TPM1_HUMAN_152 15 152 166 HIAEDADRKYEEVAR PRIDE
TPM1_HUMAN_167 15 167 181 KLVIIESDLERAEER PRIDE
TPM1_HUMAN_168 11 168 178 KLVIIESDLER PRIDE
TPM1_HUMAN_169 10 169 178 LVIIESDLER PRIDE
TPM1_HUMAN_169 14 169 182 LVIIESDLERAEER PRIDE
TPM1_HUMAN_190 9 190 198 CAELEEELK PRIDE
TPM1_HUMAN_2 4 2 5 DAIK PRIDE
TPM1_HUMAN_226 12 226 237 VLSDKLKEAETR PRIDE
TPM1_HUMAN_233 11 233 243 EAETRAEFAER PRIDE
TPM1_HUMAN_249 16 249 264 LEKSIDDLEDELYAQK PRIDE
TPM1_HUMAN_252 13 252 264 SIDDLEDELYAQK PRIDE
TPM1_HUMAN_269 16 269 284 AISEELDHALNDMTSI PRIDE
TPM1_HUMAN_35 13 35 47 SKQLEDELVSLQK PRIDE
TPM1_HUMAN_35 14 35 48 SKQLEDELVSLQKK PRIDE
TPM1_HUMAN_36 13 36 48 SKQLEDELVSLQK PRIDE
TPM1_HUMAN_37 11 37 47 QLEDELVSLQK PRIDE
TPM1_HUMAN_38 11 38 48 QLEDELVSLQK PRIDE
TPM1_HUMAN_71 6 71 76 LELAEK PRIDE
TPM1_HUMAN_76 14 76 89 KATDAEADVASLNR PRIDE
TPM1_HUMAN_77 13 77 89 ATDAEADVASLNR PRIDE
TPM1_HUMAN_77 14 77 90 ATDAEADVASLNRR PRIDE
TPM1_HUMAN_77 14 77 90 KATDAEADVASLNR PRIDE
TPM1_HUMAN_78 13 78 90 ATDAEADVASLNR PRIDE
TPM1_HUMAN_90 11 90 100 RIQLVEEELDR PRIDE
TPM1_HUMAN_90 15 90 104 RIQLVEEELDRAQER PRIDE
TPM1_HUMAN_91 10 91 100 IQLVEEELDR PRIDE
TPM1_HUMAN_91 11 91 101 RIQLVEEELDR PRIDE
TPM1_HUMAN_91 14 91 104 IQLVEEELDRAQER PRIDE
TPM1_HUMAN_92 10 92 101 IQLVEEELDR PRIDE
TPM1_HUMAN_92 14 92 105 IQLVEEELDRAQER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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