AutismKB 2.0

Annotation Detail for TPM2


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Basic Information Top
Gene Symbol:TPM2 ( AMCD1,DA1,DA2B,NEM4,TMSB )
Gene Full Name: tropomyosin 2 (beta)
Band: 9p13.3
Quick LinksEntrez ID:7169; OMIM: 190990; Uniprot ID:TPM2_HUMAN; ENSEMBL ID: ENSG00000198467; HGNC ID: 12011
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body25 / 70761353
blastocyst3 / 6231948
fetus57 / 564012101
neonate15 / 31097482
infant0 / 236200 
juvenile3 / 5555653
adult804 / 1939121414
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma39 / 82823470
colorectal tumor28 / 114246245
esophageal tumor4 / 17290231
gastrointestinal tumor27 / 119369226
germ cell tumor5 / 26384518
glioma6 / 10688356
head and neck tumor20 / 136302146
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor9 / 9635993
lung tumor67 / 103127649
lymphoma0 / 717550 
non-neoplasia15 / 97250154
normal983 / 3360307292
ovarian tumor12 / 76682156
pancreatic tumor38 / 104616363
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer9 / 10268087
retinoblastoma0 / 463560 
skin tumor14 / 124949112
soft tissue/muscle tissue tumor41 / 125191327
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland3 / 3319790
ascites4 / 4001599
bladder0 / 297570 
blood0 / 1234780 
bone16 / 71655223
bone marrow12 / 48801245
brain32 / 110098929
cervix7 / 48171145
connective tissue13 / 14925587
ear1 / 1621261
embryonic tissue40 / 215722185
esophagus4 / 20209197
eye37 / 211054175
heart56 / 89626624
intestine68 / 234472290
kidney9 / 21177742
larynx15 / 24145621
liver16 / 20774377
lung119 / 336974353
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth7 / 67052104
muscle605 / 1077155616
nerve6 / 15768380
ovary19 / 102051186
pancreas42 / 214812195
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta33 / 280825117
prostate77 / 189345406
salivary gland0 / 201550 
skin40 / 210574189
spleen4 / 5395274
stomach33 / 96619341
testis13 / 33044239
thymus2 / 8113124
thyroid9 / 47473189
tonsil0 / 169990 
trachea14 / 52413267
umbilical cord15 / 136801096
uterus210 / 232878901
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204083_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.15
Adipocyte890.2
AdrenalCortex203.75
Adrenalgland104.45
Amygdala18.7
Appendix1149.15
AtrioventricularNode69.9
BDCA4+_DentriticCells594.75
Bonemarrow17.45
BronchialEpithelialCells224
CD105+_Endothelial25.35
CD14+_Monocytes23.65
CD19+_BCells(neg._sel.)18
CD33+_Myeloid18.55
CD34+44.9
CD4+_Tcells53.95
CD56+_NKCells19.75
CD71+_EarlyErythroid23.75
CD8+_Tcells41.2
CardiacMyocytes950.9
Caudatenucleus18.55
Cerebellum15.6
CerebellumPeduncles38.25
CiliaryGanglion105.85
CingulateCortex28.35
Colorectaladenocarcinoma117.65
DorsalRootGanglion39.6
FetalThyroid78.45
Fetalbrain16.4
Fetalliver13.45
Fetallung254.2
GlobusPallidus19.55
Heart471.75
Hypothalamus51.45
Kidney28.3
Leukemia_chronicMyelogenousK-56216.15
Leukemia_promyelocytic-HL-6010.3
Leukemialymphoblastic(MOLT-4)17.85
Liver42.35
Lung544.8
Lymphnode112.65
Lymphoma_burkitts(Daudi)15.6
Lymphoma_burkitts(Raji)35.45
MedullaOblongata10.4
OccipitalLobe15.5
OlfactoryBulb182.15
Ovary431.55
Pancreas75.95
PancreaticIslet74.9
ParietalLobe34
Pituitary36.55
Placenta182.6
Pons26.55
PrefrontalCortex48.25
Prostate2979.5
Salivarygland43.95
SkeletalMuscle4826.65
Skin35.95
SmoothMuscle2195.05
Spinalcord46.1
SubthalamicNucleus33.8
SuperiorCervicalGanglion44.4
TemporalLobe25.15
Testis178
TestisGermCell1144.35
TestisIntersitial126.6
TestisLeydigCell194.85
TestisSeminiferousTubule94.65
Thalamus29.5
Thymus26.3
Thyroid803.05
Tongue888.25
Tonsil21.3
Trachea180.85
TrigeminalGanglion47.65
Uterus4286.9
UterusCorpus380.75
WholeBlood12.5
Wholebrain21.7
colon1594.2
pineal_day28.86
pineal_night38.2
retina283.725
small_intestine1203.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15803_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.34 ± 0.27
Basal Forebrain7.2 ± 0.23
Basal Part of Pons7.15 ± 0.34
Cerebellar Cortex7.32 ± 0.49
Cerebellar Nuclei7.57 ± 0.33
Claustrum7.04 ± 0.35
Epithalamus7.42 ± 0.39
Frontal Lobe7.21 ± 0.57
Globus Pallidus8.11 ± 0.38
Hypothalamus6.72 ± 0.54
Insula7.5 ± 0.35
Limbic Lobe7.47 ± 0.55
Mesencephalon7.27 ± 0.5
Myelencephalon7.4 ± 0.54
Occipital Lobe7.6 ± 0.45
Parietal Lobe7.26 ± 0.5
Pontine Tegmentum7.43 ± 0.62
Striatum7.79 ± 0.48
Subthalamus7.39 ± 0.4
Temporal Lobe7.36 ± 0.47
Thalamus7.43 ± 0.41
White Matter7.38 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tpm2CBCerebellum21.75
35.41
Tpm2CTXCerebral cortex1.76
1.63
Tpm2HIPHippocampal region2.85
3.21
Tpm2HPFHippocampal formation2.86
2.87
Tpm2HYHypothalamus0.21
0.34
Tpm2LSXLateral septal complex0.27
0.29
Tpm2MBMidbrain0.86
1.46
Tpm2MYMedulla2.7
3.58
Tpm2OLFOlfactory bulb5.02
3.73
Tpm2PPons0.66
1
Tpm2PALPallidum0.15
0.13
Tpm2RHPRetrohippocampal region2.88
2.42
Tpm2sAMYStriatum-like amygdalar nuclei0.76
0.77
Tpm2STRStriatum1.27
1.1
Tpm2STRdStriatum dorsal region1.73
1.48
Tpm2STRvStriatum ventral region0.81
0.64
Tpm2THThalamus0.55
0.64
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000992 9 190 198 CGDLEEELK Peptide Atlas
TPM2_HUMAN_0 0 0 0 IQLVEEELDR PRIDE
TPM2_HUMAN_0 0 0 0 IQLVEEELDRAQER PRIDE
TPM2_HUMAN_0 0 0 0 KLVILEGELER PRIDE
TPM2_HUMAN_0 0 0 0 LATALQKLEEAEK PRIDE
TPM2_HUMAN_0 0 0 0 LEEAEKAADESER PRIDE
TPM2_HUMAN_0 0 0 0 RIQLVEEELDRAQER PRIDE
TPM2_HUMAN_1 21 1 21 MDAIKKKMQMLKLDKENAIDR PRIDE
TPM2_HUMAN_105 13 105 117 LATALQKLEEAEK PRIDE
TPM2_HUMAN_105 20 105 124 LATALQKLEEAEKAADESER PRIDE
TPM2_HUMAN_112 13 112 124 LEEAEKAADESER PRIDE
TPM2_HUMAN_112 16 112 127 LEEAEKAADESERGMK PRIDE
TPM2_HUMAN_133 16 133 148 AMKDEEKMELQEMQLK PRIDE
TPM2_HUMAN_140 9 140 148 MELQEMQLK PRIDE
TPM2_HUMAN_167 11 167 177 KLVILEGELER PRIDE
TPM2_HUMAN_168 10 168 177 LVILEGELER PRIDE
TPM2_HUMAN_168 11 168 178 KLVILEGELER PRIDE
TPM2_HUMAN_169 10 169 178 LVILEGELER PRIDE
TPM2_HUMAN_189 9 189 197 CGDLEEELK PRIDE
TPM2_HUMAN_233 11 233 243 EAETRAEFAER PRIDE
TPM2_HUMAN_37 11 37 47 QLEEEQQALQK PRIDE
TPM2_HUMAN_38 11 38 48 QLEEEQQALQK PRIDE
TPM2_HUMAN_76 14 76 89 KATDAEADVASLNR PRIDE
TPM2_HUMAN_77 13 77 89 ATDAEADVASLNR PRIDE
TPM2_HUMAN_77 14 77 90 ATDAEADVASLNRR PRIDE
TPM2_HUMAN_77 14 77 90 KATDAEADVASLNR PRIDE
TPM2_HUMAN_78 13 78 90 ATDAEADVASLNR PRIDE
TPM2_HUMAN_90 11 90 100 RIQLVEEELDR PRIDE
TPM2_HUMAN_90 15 90 104 RIQLVEEELDRAQER PRIDE
TPM2_HUMAN_91 10 91 100 IQLVEEELDR PRIDE
TPM2_HUMAN_91 14 91 104 IQLVEEELDRAQER PRIDE
TPM2_HUMAN_92 10 92 101 IQLVEEELDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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