AutismKB 2.0

Annotation Detail for TPM3


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Basic Information Top
Gene Symbol:TPM3 ( FLJ41118,MGC14582,MGC3261,MGC72094,NEM1,OK/SW-cl.5,TM-5,TM3,TM30,TM30nm,TPMsk3,TRK,hscp30 )
Gene Full Name: tropomyosin 3
Band: 1q21.3
Quick LinksEntrez ID:7170; OMIM: 191030; Uniprot ID:TPM3_HUMAN; ENSEMBL ID: ENSG00000143549; HGNC ID: 12012
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body20 / 70761282
blastocyst13 / 62319208
fetus106 / 564012187
neonate4 / 31097128
infant3 / 23620127
juvenile11 / 55556197
adult664 / 1939121342
embryoid body12 / 70761169
blastocyst20 / 62319320
fetus10 / 56401217
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor40 / 94178424
cervical tumor15 / 34366436
chondrosarcoma31 / 82823374
colorectal tumor29 / 114246253
esophageal tumor4 / 17290231
gastrointestinal tumor26 / 119369217
germ cell tumor86 / 263845325
glioma33 / 106883308
head and neck tumor19 / 136302139
kidney tumor35 / 68959507
leukemia33 / 95842344
liver tumor24 / 96359249
lung tumor36 / 103127349
lymphoma9 / 71755125
non-neoplasia13 / 97250133
normal800 / 3360307238
ovarian tumor31 / 76682404
pancreatic tumor44 / 104616420
primitive neuroectodermal tumor of the CNS30 / 125680238
prostate cancer55 / 102680535
retinoblastoma15 / 46356323
skin tumor44 / 124949352
soft tissue/muscle tissue tumor65 / 125191519
uterine tumor20 / 90257221
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor12 / 94178127
cervical tumor10 / 34366290
chondrosarcoma7 / 8282384
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor34 / 263845128
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor14 / 68959203
leukemia5 / 9584252
liver tumor6 / 9635962
lung tumor21 / 103127203
lymphoma11 / 71755153
non-neoplasia5 / 9725051
normal151 / 336030744
ovarian tumor6 / 7668278
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer27 / 102680262
retinoblastoma17 / 46356366
skin tumor28 / 124949224
soft tissue/muscle tissue tumor22 / 125191175
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites8 / 40015199
bladder5 / 29757168
blood44 / 123478356
bone36 / 71655502
bone marrow9 / 48801184
brain166 / 1100989150
cervix17 / 48171352
connective tissue50 / 149255334
ear4 / 16212246
embryonic tissue60 / 215722278
esophagus4 / 20209197
eye46 / 211054217
heart23 / 89626256
intestine54 / 234472230
kidney53 / 211777250
larynx12 / 24145496
liver57 / 207743274
lung107 / 336974317
lymph4 / 4427090
lymph node19 / 91610207
mammary gland59 / 153271384
mouth9 / 67052134
muscle256 / 1077152376
nerve4 / 15768253
ovary38 / 102051372
pancreas51 / 214812237
parathyroid2 / 2053997
pharynx10 / 41328241
pituitary gland2 / 16585120
placenta41 / 280825145
prostate97 / 189345512
salivary gland4 / 20155198
skin71 / 210574337
spleen8 / 53952148
stomach24 / 96619248
testis57 / 330442172
thymus6 / 8113173
thyroid9 / 47473189
tonsil19 / 169991117
trachea0 / 524130 
umbilical cord3 / 13680219
uterus70 / 232878300
vascular12 / 51780231
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites5 / 40015124
bladder1 / 2975733
blood7 / 12347856
bone2 / 7165527
bone marrow1 / 4880120
brain26 / 110098923
cervix10 / 48171207
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue50 / 215722231
esophagus0 / 202090 
eye25 / 211054118
heart1 / 8962611
intestine12 / 23447251
kidney15 / 21177770
larynx0 / 241450 
liver7 / 20774333
lung25 / 33697474
lymph11 / 44270248
lymph node1 / 9161010
mammary gland12 / 15327178
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary8 / 10205178
pancreas32 / 214812148
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta21 / 28082574
prostate29 / 189345153
salivary gland2 / 2015599
skin31 / 210574147
spleen4 / 5395274
stomach0 / 966190 
testis10 / 33044230
thymus3 / 8113136
thyroid2 / 4747342
tonsil6 / 16999352
trachea1 / 5241319
umbilical cord0 / 136800 
uterus27 / 232878115
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214365_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte7.15
AdrenalCortex7.5
Adrenalgland6.3
Amygdala12.2
Appendix7.55
AtrioventricularNode6.6
BDCA4+_DentriticCells8.5
Bonemarrow7.3
BronchialEpithelialCells7.2
CD105+_Endothelial7.7
CD14+_Monocytes7.5
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid9.8
CD34+9.1
CD4+_Tcells7.25
CD56+_NKCells8.85
CD71+_EarlyErythroid6.95
CD8+_Tcells7.15
CardiacMyocytes11.3
Caudatenucleus7.95
Cerebellum12.35
CerebellumPeduncles9.3
CiliaryGanglion5.2
CingulateCortex8.2
Colorectaladenocarcinoma7.4
DorsalRootGanglion5.6
FetalThyroid13.55
Fetalbrain8.9
Fetalliver6.35
Fetallung6
GlobusPallidus5.95
Heart10.35
Hypothalamus9.85
Kidney6.05
Leukemia_chronicMyelogenousK-5626.65
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)5.8
Liver9.95
Lung8.05
Lymphnode6.2
Lymphoma_burkitts(Daudi)9.65
Lymphoma_burkitts(Raji)10.5
MedullaOblongata8.55
OccipitalLobe7.5
OlfactoryBulb6
Ovary4.95
Pancreas6.1
PancreaticIslet7.95
ParietalLobe9.35
Pituitary8.5
Placenta7.65
Pons7.3
PrefrontalCortex9.6
Prostate10.35
Salivarygland6
SkeletalMuscle1276.65
Skin5.65
SmoothMuscle8.6
Spinalcord9.65
SubthalamicNucleus14.2
SuperiorCervicalGanglion8.6
TemporalLobe12.55
Testis10.9
TestisGermCell6.2
TestisIntersitial6.3
TestisLeydigCell7.5
TestisSeminiferousTubule6.45
Thalamus11.7
Thymus5.7
Thyroid124.25
Tongue352.25
Tonsil7.35
Trachea6.2
TrigeminalGanglion8.75
Uterus6.05
UterusCorpus6.7
WholeBlood8.25
Wholebrain11.95
colon7.7
pineal_day9.42
pineal_night9.14
retina10.05
small_intestine9.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P161244
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.38 ± 0.48
Basal Forebrain4.95 ± 0.32
Basal Part of Pons4.66 ± 0.52
Cerebellar Cortex4.45 ± 0.35
Cerebellar Nuclei4.75 ± 0.31
Claustrum5.99 ± 0.54
Epithalamus4.87 ± 0.48
Frontal Lobe5.11 ± 0.52
Globus Pallidus5.21 ± 0.35
Hypothalamus4.86 ± 0.47
Insula5.08 ± 0.62
Limbic Lobe5.28 ± 0.42
Mesencephalon4.97 ± 0.55
Myelencephalon4.96 ± 0.55
Occipital Lobe4.47 ± 0.52
Parietal Lobe4.92 ± 0.44
Pontine Tegmentum5.04 ± 0.56
Striatum5.21 ± 0.47
Subthalamus4.68 ± 0.23
Temporal Lobe5.11 ± 0.48
Thalamus4.72 ± 0.54
White Matter5.03 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tpm3CBCerebellum60.69
100
Tpm3CTXCerebral cortex100
100
Tpm3HIPHippocampal region100
100
Tpm3HPFHippocampal formation100
100
Tpm3HYHypothalamus100
100
Tpm3LSXLateral septal complex100
100
Tpm3MBMidbrain100
100
Tpm3MYMedulla89.2
100
Tpm3OLFOlfactory bulb100
100
Tpm3PPons99.5
100
Tpm3PALPallidum100
100
Tpm3RHPRetrohippocampal region100
100
Tpm3sAMYStriatum-like amygdalar nuclei100
100
Tpm3STRStriatum100
100
Tpm3STRdStriatum dorsal region100
100
Tpm3STRvStriatum ventral region100
100
Tpm3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001180 8 170 177 CLSAAEEK Peptide Atlas
TPM3_HUMAN_0 0 0 0 AADAEAEVASLNR PRIDE
TPM3_HUMAN_0 0 0 0 AADAEAEVASLNRR PRIDE
TPM3_HUMAN_0 0 0 0 HIAEEADRKYEEVAR PRIDE
TPM3_HUMAN_0 0 0 0 IQLVEEELDR PRIDE
TPM3_HUMAN_0 0 0 0 IQLVEEELDRAQER PRIDE
TPM3_HUMAN_0 0 0 0 KLVIIEGDLERTEER PRIDE
TPM3_HUMAN_0 0 0 0 LATALQKLEEAEK PRIDE
TPM3_HUMAN_0 0 0 0 LEEAEKAADESER PRIDE
TPM3_HUMAN_0 0 0 0 RIQLVEEELDRAQER PRIDE
TPM3_HUMAN_0 0 0 0 YSQKEDKYEEEIK PRIDE
TPM3_HUMAN_1 21 1 21 MEAIKKKMQMLKLDKENALDR PRIDE
TPM3_HUMAN_105 13 105 117 LATALQKLEEAEK PRIDE
TPM3_HUMAN_105 20 105 124 LATALQKLEEAEKAADESER PRIDE
TPM3_HUMAN_106 13 106 118 LATALQKLEEAEK PRIDE
TPM3_HUMAN_112 13 112 124 LEEAEKAADESER PRIDE
TPM3_HUMAN_112 16 112 127 LEEAEKAADESERGMK PRIDE
TPM3_HUMAN_133 16 133 148 ALKDEEKMELQEIQLK PRIDE
TPM3_HUMAN_140 9 140 148 MELQEIQLK PRIDE
TPM3_HUMAN_152 15 152 166 HIAEEADRKYEEVAR PRIDE
TPM3_HUMAN_167 11 167 177 KLVIIEGDLER PRIDE
TPM3_HUMAN_167 15 167 181 KLVIIEGDLERTEER PRIDE
TPM3_HUMAN_168 10 168 177 LVIIEGDLER PRIDE
TPM3_HUMAN_168 14 168 181 LVIIEGDLERTEER PRIDE
TPM3_HUMAN_213 13 213 225 YSQKEDKYEEEIK PRIDE
TPM3_HUMAN_226 12 226 237 ILTDKLKEAETR PRIDE
TPM3_HUMAN_226 7 226 232 ILTDKLK PRIDE
TPM3_HUMAN_233 11 233 243 EAETRAEFAER PRIDE
TPM3_HUMAN_77 13 77 89 AADAEAEVASLNR PRIDE
TPM3_HUMAN_77 14 77 90 AADAEAEVASLNRR PRIDE
TPM3_HUMAN_90 11 90 100 RIQLVEEELDR PRIDE
TPM3_HUMAN_90 15 90 104 RIQLVEEELDRAQER PRIDE
TPM3_HUMAN_91 10 91 100 IQLVEEELDR PRIDE
TPM3_HUMAN_91 14 91 104 IQLVEEELDRAQER PRIDE
TPM3_HUMAN_92 10 92 101 IQLVEEELDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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