AutismKB 2.0

Annotation Detail for TPM4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TPM4 ( - )
Gene Full Name: tropomyosin 4
Band: 19p13.12-p13.11
Quick LinksEntrez ID:7171; OMIM: 600317; Uniprot ID:TPM4_HUMAN; ENSEMBL ID: ENSG00000167460; HGNC ID: 12013
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst8 / 62319128
fetus20 / 56401235
neonate9 / 31097289
infant3 / 23620127
juvenile4 / 5555671
adult199 / 1939121102
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor17 / 94178180
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor18 / 114246157
esophageal tumor6 / 17290347
gastrointestinal tumor12 / 119369100
germ cell tumor27 / 263845102
glioma8 / 10688374
head and neck tumor11 / 13630280
kidney tumor7 / 68959101
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor9 / 10312787
lymphoma2 / 7175527
non-neoplasia17 / 97250174
normal278 / 336030782
ovarian tumor10 / 76682130
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer5 / 10268048
retinoblastoma4 / 4635686
skin tumor7 / 12494956
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites4 / 4001599
bladder8 / 29757268
blood7 / 12347856
bone6 / 7165583
bone marrow3 / 4880161
brain69 / 110098962
cervix6 / 48171124
connective tissue21 / 149255140
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus7 / 20209346
eye7 / 21105433
heart5 / 8962655
intestine35 / 234472149
kidney15 / 21177770
larynx1 / 2414541
liver8 / 20774338
lung25 / 33697474
lymph2 / 4427045
lymph node1 / 9161010
mammary gland41 / 153271267
mouth8 / 67052119
muscle6 / 10771555
nerve0 / 157680 
ovary11 / 102051107
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta14 / 28082549
prostate13 / 18934568
salivary gland2 / 2015599
skin26 / 210574123
spleen11 / 53952203
stomach28 / 96619289
testis11 / 33044233
thymus0 / 811310 
thyroid2 / 4747342
tonsil3 / 16999176
trachea1 / 5241319
umbilical cord4 / 13680292
uterus53 / 232878227
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209344_at
Cell line Expression level Expression bar
721_B_lymphoblasts605.65
Adipocyte1010.85
AdrenalCortex34.45
Adrenalgland31.95
Amygdala32.45
Appendix48.4
AtrioventricularNode79
BDCA4+_DentriticCells121.15
Bonemarrow39.85
BronchialEpithelialCells387.1
CD105+_Endothelial20.15
CD14+_Monocytes173.85
CD19+_BCells(neg._sel.)54.2
CD33+_Myeloid74.85
CD34+56.85
CD4+_Tcells43.25
CD56+_NKCells88.3
CD71+_EarlyErythroid23.45
CD8+_Tcells32.4
CardiacMyocytes872.6
Caudatenucleus27.75
Cerebellum70.05
CerebellumPeduncles192
CiliaryGanglion46.75
CingulateCortex29.6
Colorectaladenocarcinoma250.75
DorsalRootGanglion61.9
FetalThyroid27.45
Fetalbrain29.1
Fetalliver21.3
Fetallung282.35
GlobusPallidus25.05
Heart36.75
Hypothalamus25.2
Kidney30.5
Leukemia_chronicMyelogenousK-56246.15
Leukemia_promyelocytic-HL-6026.6
Leukemialymphoblastic(MOLT-4)87.7
Liver37.4
Lung45.1
Lymphnode51.8
Lymphoma_burkitts(Daudi)27.4
Lymphoma_burkitts(Raji)41.5
MedullaOblongata23.35
OccipitalLobe32.1
OlfactoryBulb50.65
Ovary149.7
Pancreas32.65
PancreaticIslet75
ParietalLobe32.65
Pituitary34.9
Placenta331.7
Pons25.8
PrefrontalCortex31.45
Prostate38.15
Salivarygland17.6
SkeletalMuscle36.05
Skin37.45
SmoothMuscle866.5
Spinalcord29.2
SubthalamicNucleus34.25
SuperiorCervicalGanglion70.8
TemporalLobe26.4
Testis14.55
TestisGermCell35.8
TestisIntersitial23.35
TestisLeydigCell28.75
TestisSeminiferousTubule23
Thalamus27.95
Thymus18.35
Thyroid39.2
Tongue51.95
Tonsil78
Trachea72.75
TrigeminalGanglion29.25
Uterus125.4
UterusCorpus103.9
WholeBlood172.5
Wholebrain18.4
colon54.05
pineal_day33.08
pineal_night35.28
retina72.9
small_intestine65.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P82880
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.61 ± 0.29
Basal Forebrain9.57 ± 0.34
Basal Part of Pons9.57 ± 0.18
Cerebellar Cortex9.95 ± 0.17
Cerebellar Nuclei10.02 ± 0.18
Claustrum9.63 ± 0.28
Epithalamus9.29 ± 0.37
Frontal Lobe9.5 ± 0.27
Globus Pallidus10.15 ± 0.41
Hypothalamus9.17 ± 0.29
Insula9.45 ± 0.26
Limbic Lobe9.72 ± 0.39
Mesencephalon9.63 ± 0.36
Myelencephalon9.68 ± 0.34
Occipital Lobe9.92 ± 0.28
Parietal Lobe9.65 ± 0.33
Pontine Tegmentum9.65 ± 0.43
Striatum9.73 ± 0.46
Subthalamus9.86 ± 0.12
Temporal Lobe9.55 ± 0.27
Thalamus9.66 ± 0.2
White Matter10.68 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tpm4CBCerebellum2.2
3.4
Tpm4CTXCerebral cortex1.02
1.03
Tpm4HIPHippocampal region1.13
1.34
Tpm4HPFHippocampal formation1.19
1.4
Tpm4HYHypothalamus0.67
0.49
Tpm4LSXLateral septal complex1.85
1.49
Tpm4MBMidbrain1.32
1.18
Tpm4MYMedulla3.43
3.54
Tpm4OLFOlfactory bulb1.26
1.19
Tpm4PPons1.53
1.98
Tpm4PALPallidum0.23
0.17
Tpm4RHPRetrohippocampal region1.33
1.56
Tpm4sAMYStriatum-like amygdalar nuclei0.13
0.17
Tpm4STRStriatum1.43
1.45
Tpm4STRdStriatum dorsal region1.85
2.01
Tpm4STRvStriatum ventral region0.63
0.51
Tpm4THThalamus0.84
0.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000303 23 147 169 AEVSELKCGDLEEELKNVTNNLK Peptide Atlas
TPM4_HUMAN_0 0 0 0 HIAEEADRKYEEVAR PRIDE
TPM4_HUMAN_0 0 0 0 IQALQQQADEAEDR PRIDE
TPM4_HUMAN_0 0 0 0 IQLVEEELDR PRIDE
TPM4_HUMAN_0 0 0 0 IQLVEEELDRAQER PRIDE
TPM4_HUMAN_0 0 0 0 KIQALQQQADEAEDR PRIDE
TPM4_HUMAN_0 0 0 0 KLVILEGELER PRIDE
TPM4_HUMAN_0 0 0 0 LATALQKLEEAEK PRIDE
TPM4_HUMAN_0 0 0 0 LEEAEKAADESER PRIDE
TPM4_HUMAN_0 0 0 0 LLSDKLKEAETR PRIDE
TPM4_HUMAN_0 0 0 0 RIQLVEEELDRAQER PRIDE
TPM4_HUMAN_0 0 0 0 YSEKEDKYEEEIK PRIDE
TPM4_HUMAN_1 11 1 11 AGLNSLEAVKR PRIDE
TPM4_HUMAN_104 9 104 112 MEIQEMQLK PRIDE
TPM4_HUMAN_11 16 11 26 RKIQALQQQADEAEDR PRIDE
TPM4_HUMAN_116 15 116 130 HIAEEADRKYEEVAR PRIDE
TPM4_HUMAN_116 8 116 123 HIAEEADR PRIDE
TPM4_HUMAN_12 15 12 26 KIQALQQQADEAEDR PRIDE
TPM4_HUMAN_12 21 12 32 KIQALQQQADEAEDRAQGLQR PRIDE
TPM4_HUMAN_13 14 13 26 IQALQQQADEAEDR PRIDE
TPM4_HUMAN_13 20 13 32 IQALQQQADEAEDRAQGLQR PRIDE
TPM4_HUMAN_131 11 131 141 KLVILEGELER PRIDE
TPM4_HUMAN_131 15 131 145 KLVILEGELERAEER PRIDE
TPM4_HUMAN_132 10 132 141 LVILEGELER PRIDE
TPM4_HUMAN_132 14 132 145 LVILEGELERAEER PRIDE
TPM4_HUMAN_132 21 132 152 LVILEGELERAEERAEVSELK PRIDE
TPM4_HUMAN_142 11 142 152 AEERAEVSELK PRIDE
TPM4_HUMAN_146 23 146 168 AEVSELKCGDLEEELKNVTNNLK PRIDE
TPM4_HUMAN_153 16 153 168 CGDLEEELKNVTNNLK PRIDE
TPM4_HUMAN_153 9 153 161 CGDLEEELK PRIDE
TPM4_HUMAN_177 13 177 189 YSEKEDKYEEEIK PRIDE
TPM4_HUMAN_190 12 190 201 LLSDKLKEAETR PRIDE
TPM4_HUMAN_190 7 190 196 LLSDKLK PRIDE
TPM4_HUMAN_197 11 197 207 EAETRAEFAER PRIDE
TPM4_HUMAN_2 11 2 12 AGLNSLEAVKR PRIDE
TPM4_HUMAN_215 13 215 227 TIDDLEEKLAQAK PRIDE
TPM4_HUMAN_215 33 215 247 TIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI PRIDE
TPM4_HUMAN_223 25 223 247 LAQAKEENVGLHQTLDQTLNELNCI PRIDE
TPM4_HUMAN_228 20 228 247 EENVGLHQTLDQTLNELNCI PRIDE
TPM4_HUMAN_3 9 3 11 LNSLEAVKR PRIDE
TPM4_HUMAN_41 13 41 53 REKAEGDVAALNR PRIDE
TPM4_HUMAN_42 12 42 53 EKAEGDVAALNR PRIDE
TPM4_HUMAN_42 13 42 54 EKAEGDVAALNRR PRIDE
TPM4_HUMAN_54 11 54 64 RIQLVEEELDR PRIDE
TPM4_HUMAN_54 15 54 68 RIQLVEEELDRAQER PRIDE
TPM4_HUMAN_55 10 55 64 IQLVEEELDR PRIDE
TPM4_HUMAN_55 14 55 68 IQLVEEELDRAQER PRIDE
TPM4_HUMAN_69 13 69 81 LATALQKLEEAEK PRIDE
TPM4_HUMAN_69 20 69 88 LATALQKLEEAEKAADESER PRIDE
TPM4_HUMAN_76 13 76 88 LEEAEKAADESER PRIDE
TPM4_HUMAN_76 16 76 91 LEEAEKAADESERGMK PRIDE
TPM4_HUMAN_97 16 97 112 AMKDEEKMEIQEMQLK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved