AutismKB 2.0

Annotation Detail for TPMT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TPMT ( - )
Gene Full Name: thiopurine S-methyltransferase
Band: 6p22.3
Quick LinksEntrez ID:7172; OMIM: 187680; Uniprot ID:TPMT_HUMAN; ENSEMBL ID: ENSG00000137364; HGNC ID: 12014
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst6 / 6231996
fetus10 / 56401217
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma3 / 17475171
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor9 / 11424678
esophageal tumor2 / 17290115
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia15 / 95842156
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal122 / 336030736
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor13 / 124949104
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder2 / 2975767
blood5 / 12347840
bone3 / 7165541
bone marrow12 / 48801245
brain41 / 110098937
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus2 / 2020998
eye6 / 21105428
heart1 / 8962611
intestine13 / 23447255
kidney14 / 21177766
larynx0 / 241450 
liver12 / 20774357
lung15 / 33697444
lymph0 / 442700 
lymph node6 / 9161065
mammary gland6 / 15327139
mouth4 / 6705259
muscle3 / 10771527
nerve1 / 1576863
ovary1 / 1020519
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta1 / 2808253
prostate11 / 18934558
salivary gland2 / 2015599
skin13 / 21057461
spleen1 / 5395218
stomach1 / 9661910
testis12 / 33044236
thymus1 / 8113112
thyroid9 / 47473189
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203672_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.95
Adipocyte18.6
AdrenalCortex22.5
Adrenalgland6.95
Amygdala8.15
Appendix32.95
AtrioventricularNode123.65
BDCA4+_DentriticCells9.15
Bonemarrow7.55
BronchialEpithelialCells9.75
CD105+_Endothelial23.15
CD14+_Monocytes46.5
CD19+_BCells(neg._sel.)10.45
CD33+_Myeloid39.8
CD34+18.3
CD4+_Tcells6.45
CD56+_NKCells37.25
CD71+_EarlyErythroid13.8
CD8+_Tcells7.7
CardiacMyocytes17.05
Caudatenucleus11.5
Cerebellum9.1
CerebellumPeduncles9.8
CiliaryGanglion89.35
CingulateCortex9.4
Colorectaladenocarcinoma7.2
DorsalRootGanglion100.6
FetalThyroid68.85
Fetalbrain7.9
Fetalliver9.7
Fetallung8.75
GlobusPallidus25.35
Heart8.6
Hypothalamus9.45
Kidney11.1
Leukemia_chronicMyelogenousK-56214.65
Leukemia_promyelocytic-HL-609.6
Leukemialymphoblastic(MOLT-4)8.55
Liver9.65
Lung7.6
Lymphnode9.15
Lymphoma_burkitts(Daudi)10.35
Lymphoma_burkitts(Raji)10.1
MedullaOblongata8.15
OccipitalLobe8.3
OlfactoryBulb6.3
Ovary37.25
Pancreas8.15
PancreaticIslet9.85
ParietalLobe7.75
Pituitary16.85
Placenta7.25
Pons10.45
PrefrontalCortex9.45
Prostate8.8
Salivarygland30.7
SkeletalMuscle28.5
Skin99.9
SmoothMuscle26.1
Spinalcord8.35
SubthalamicNucleus25.25
SuperiorCervicalGanglion90
TemporalLobe11.25
Testis5.85
TestisGermCell7.95
TestisIntersitial8.7
TestisLeydigCell48.5
TestisSeminiferousTubule10.3
Thalamus9.8
Thymus6.7
Thyroid82.4
Tongue38.45
Tonsil11.45
Trachea7.8
TrigeminalGanglion80.3
Uterus6.2
UterusCorpus7.65
WholeBlood10.25
Wholebrain6.8
colon8.7
pineal_day9.04
pineal_night8.44
retina14.675
small_intestine11.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P67375
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.68 ± 0.66
Basal Forebrain5.46 ± 0.51
Basal Part of Pons5.81 ± 0.33
Cerebellar Cortex5.8 ± 0.26
Cerebellar Nuclei5.12 ± 0.58
Claustrum6.43 ± 0.27
Epithalamus5.35 ± 0.55
Frontal Lobe5.58 ± 0.37
Globus Pallidus4.79 ± 0.34
Hypothalamus5.23 ± 0.37
Insula5.71 ± 0.25
Limbic Lobe5.25 ± 0.51
Mesencephalon5.54 ± 0.5
Myelencephalon5.41 ± 0.57
Occipital Lobe5.46 ± 0.56
Parietal Lobe5.68 ± 0.43
Pontine Tegmentum5.37 ± 0.51
Striatum4.79 ± 0.52
Subthalamus5.24 ± 0.33
Temporal Lobe5.65 ± 0.49
Thalamus5.6 ± 0.44
White Matter4.62 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TpmtCBCerebellum2.4
3.83
TpmtCTXCerebral cortex0.82
0.88
TpmtHIPHippocampal region0.49
0.42
TpmtHPFHippocampal formation0.4
0.32
TpmtHYHypothalamus0.32
0.19
TpmtLSXLateral septal complex0
0
TpmtMBMidbrain0.46
0.36
TpmtMYMedulla1.05
0.62
TpmtOLFOlfactory bulb0.64
1.31
TpmtPPons0.49
0.37
TpmtPALPallidum0.12
0.14
TpmtRHPRetrohippocampal region0.27
0.2
TpmtsAMYStriatum-like amygdalar nuclei0.62
1.44
TpmtSTRStriatum0.3
0.39
TpmtSTRdStriatum dorsal region0.25
0.25
TpmtSTRvStriatum ventral region0.29
0.36
TpmtTHThalamus0.4
0.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007534 10 229 238 SWGIDCLFEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved