AutismKB 2.0

Annotation Detail for TPO


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Basic Information Top
Gene Symbol:TPO ( MSA,TDH2A,TPX )
Gene Full Name: thyroid peroxidase
Band: 2p25.3
Quick LinksEntrez ID:7173; OMIM: 606765; Uniprot ID:PERT_HUMAN; ENSEMBL ID: ENSG00000115705; HGNC ID: 12015
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult30 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor9 / 13630266
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal32 / 33603079
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine1 / 2344724
kidney0 / 2117770 
larynx1 / 2414541
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid29 / 47473610
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210342_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.1
Adipocyte4.05
AdrenalCortex4.3
Adrenalgland3.4
Amygdala4.2
Appendix4.1
AtrioventricularNode3.1
BDCA4+_DentriticCells4.4
Bonemarrow4
BronchialEpithelialCells4
CD105+_Endothelial4.1
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)4.35
CD33+_Myeloid5.2
CD34+5.15
CD4+_Tcells4.4
CD56+_NKCells4.8
CD71+_EarlyErythroid3.8
CD8+_Tcells3.9
CardiacMyocytes5.4
Caudatenucleus3.6
Cerebellum3.25
CerebellumPeduncles4.65
CiliaryGanglion2.9
CingulateCortex4.25
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.15
FetalThyroid4899.35
Fetalbrain4
Fetalliver3.55
Fetallung3.3
GlobusPallidus3
Heart5.15
Hypothalamus4.4
Kidney3.25
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.6
Leukemialymphoblastic(MOLT-4)3.25
Liver5.45
Lung4.4
Lymphnode5.3
Lymphoma_burkitts(Daudi)5.2
Lymphoma_burkitts(Raji)5.7
MedullaOblongata3.7
OccipitalLobe3.6
OlfactoryBulb3.2
Ovary2.7
Pancreas3.2
PancreaticIslet4.35
ParietalLobe4.25
Pituitary4.75
Placenta4.1
Pons3.8
PrefrontalCortex5.05
Prostate4.7
Salivarygland3.2
SkeletalMuscle4.75
Skin3.1
SmoothMuscle4.6
Spinalcord4.3
SubthalamicNucleus3.75
SuperiorCervicalGanglion4.6
TemporalLobe3.7
Testis3.5
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.45
Thalamus4.1
Thymus3.2
Thyroid8261.75
Tongue4
Tonsil3.9
Trachea3.4
TrigeminalGanglion4.1
Uterus3.3
UterusCorpus3.6
WholeBlood4.4
Wholebrain3.4
colon4.05
pineal_day5.08
pineal_night4.96
retina4.9
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11823_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.78 ± 1.09
Basal Forebrain2.42 ± 0.26
Basal Part of Pons2.1 ± 0.37
Cerebellar Cortex2.68 ± 0.7
Cerebellar Nuclei2.7 ± 0.82
Claustrum3.23 ± 0.87
Epithalamus2.14 ± 0.85
Frontal Lobe2.34 ± 0.73
Globus Pallidus2.76 ± 0.68
Hypothalamus2.34 ± 0.61
Insula2.31 ± 0.56
Limbic Lobe2.57 ± 0.76
Mesencephalon2.57 ± 0.69
Myelencephalon2.53 ± 0.71
Occipital Lobe2.6 ± 0.75
Parietal Lobe2.56 ± 0.88
Pontine Tegmentum2.56 ± 0.77
Striatum2.44 ± 0.74
Subthalamus2.67 ± 0.89
Temporal Lobe2.39 ± 0.76
Thalamus2.48 ± 0.74
White Matter2.54 ± 0.57
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TpoCBCerebellum1.28
1.66
TpoCTXCerebral cortex0.39
0.39
TpoHIPHippocampal region0.4
0.45
TpoHPFHippocampal formation0.35
0.37
TpoHYHypothalamus0.49
0.28
TpoLSXLateral septal complex0.19
0.15
TpoMBMidbrain0.73
0.55
TpoMYMedulla1.02
0.75
TpoOLFOlfactory bulb0.62
0.35
TpoPPons4.95
5.47
TpoPALPallidum2.53
1.5
TpoRHPRetrohippocampal region0.25
0.24
TposAMYStriatum-like amygdalar nuclei0.18
0.11
TpoSTRStriatum0.5
0.33
TpoSTRdStriatum dorsal region0.32
0.23
TpoSTRvStriatum ventral region1.25
0.71
TpoTHThalamus1.45
1.11
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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