AutismKB 2.0

Annotation Detail for TPP2


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Basic Information Top
Gene Symbol:TPP2 ( FLJ40359,TPP-2 )
Gene Full Name: tripeptidyl peptidase II
Band: 13q33.1
Quick LinksEntrez ID:7174; OMIM: 190470; Uniprot ID:TPP2_HUMAN; ENSEMBL ID: ENSG00000134900; HGNC ID: 12016
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus42 / 56401274
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult122 / 193912162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor7 / 11424661
esophageal tumor2 / 17290115
gastrointestinal tumor4 / 11936933
germ cell tumor15 / 26384556
glioma4 / 10688337
head and neck tumor8 / 13630258
kidney tumor3 / 6895943
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor15 / 103127145
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal199 / 336030759
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor32 / 125191255
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood6 / 12347848
bone9 / 71655125
bone marrow1 / 4880120
brain48 / 110098943
cervix1 / 4817120
connective tissue38 / 149255254
ear2 / 16212123
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye5 / 21105423
heart3 / 8962633
intestine15 / 23447263
kidney6 / 21177728
larynx0 / 241450 
liver9 / 20774343
lung31 / 33697491
lymph1 / 4427022
lymph node9 / 9161098
mammary gland3 / 15327119
mouth8 / 67052119
muscle4 / 10771537
nerve0 / 157680 
ovary2 / 10205119
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate8 / 18934542
salivary gland1 / 2015549
skin11 / 21057452
spleen0 / 539520 
stomach1 / 9661910
testis126 / 330442381
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus7 / 23287830
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203374_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts116.15
Adipocyte3.9
AdrenalCortex3.65
Adrenalgland3
Amygdala3.75
Appendix3.55
AtrioventricularNode2.7
BDCA4+_DentriticCells88.5
Bonemarrow3.5
BronchialEpithelialCells3.55
CD105+_Endothelial24.65
CD14+_Monocytes18
CD19+_BCells(neg._sel.)41.5
CD33+_Myeloid81.35
CD34+132.1
CD4+_Tcells142.2
CD56+_NKCells175.15
CD71+_EarlyErythroid3.7
CD8+_Tcells152.65
CardiacMyocytes4.55
Caudatenucleus3.2
Cerebellum3.3
CerebellumPeduncles4.05
CiliaryGanglion2.5
CingulateCortex3.65
Colorectaladenocarcinoma4.35
DorsalRootGanglion2.65
FetalThyroid3.85
Fetalbrain3.6
Fetalliver3.4
Fetallung4.05
GlobusPallidus2.75
Heart4.45
Hypothalamus4
Kidney2.9
Leukemia_chronicMyelogenousK-56239.1
Leukemia_promyelocytic-HL-6021.3
Leukemialymphoblastic(MOLT-4)30.2
Liver4.6
Lung3.9
Lymphnode6.55
Lymphoma_burkitts(Daudi)11.05
Lymphoma_burkitts(Raji)5.3
MedullaOblongata3.3
OccipitalLobe3.25
OlfactoryBulb2.85
Ovary2.35
Pancreas4.35
PancreaticIslet4.65
ParietalLobe3.7
Pituitary4.2
Placenta3.7
Pons3.4
PrefrontalCortex4.5
Prostate4.15
Salivarygland2.85
SkeletalMuscle4.15
Skin2.7
SmoothMuscle5.05
Spinalcord3.8
SubthalamicNucleus3.2
SuperiorCervicalGanglion4.3
TemporalLobe3.2
Testis8.95
TestisGermCell140.75
TestisIntersitial415.3
TestisLeydigCell190.65
TestisSeminiferousTubule156.55
Thalamus3.65
Thymus2.85
Thyroid4.5
Tongue3.75
Tonsil6
Trachea3
TrigeminalGanglion3.45
Uterus2.9
UterusCorpus3.2
WholeBlood4.7
Wholebrain3
colon3.6
pineal_day62.2
pineal_night32.44
retina4.25
small_intestine3.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13987_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.4 ± 0.2
Basal Forebrain8.28 ± 0.27
Basal Part of Pons8.51 ± 0.21
Cerebellar Cortex8.56 ± 0.22
Cerebellar Nuclei8.6 ± 0.23
Claustrum8.72 ± 0.36
Epithalamus8.33 ± 0.24
Frontal Lobe8.38 ± 0.23
Globus Pallidus8.54 ± 0.13
Hypothalamus8.18 ± 0.21
Insula8.36 ± 0.18
Limbic Lobe8.5 ± 0.25
Mesencephalon8.41 ± 0.3
Myelencephalon8.44 ± 0.23
Occipital Lobe8.76 ± 0.3
Parietal Lobe8.47 ± 0.23
Pontine Tegmentum8.44 ± 0.25
Striatum8.61 ± 0.25
Subthalamus8.32 ± 0.25
Temporal Lobe8.31 ± 0.22
Thalamus8.58 ± 0.22
White Matter9.12 ± 0.11
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000214 13 208 220 ACIDSNEDGDLSK Peptide Atlas
TPP2_HUMAN_1072 27 1072 1098 LNEIVDAANAVISHIDQTALAVYIAMK PRIDE
TPP2_HUMAN_207 13 207 219 ACIDSNEDGDLSK PRIDE
TPP2_HUMAN_340 11 340 350 ICEVINEAVWK PRIDE
TPP2_HUMAN_36 27 36 62 GVLIAVLDTGVDPGAPGMQVTTDGKPK PRIDE
TPP2_HUMAN_893 9 893 901 HEQISDLER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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