AutismKB 2.0

Annotation Detail for TPR


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Basic Information Top
Gene Symbol:TPR ( - )
Gene Full Name: translocated promoter region (to activated MET oncogene)
Band: 1q31.1
Quick LinksEntrez ID:7175; OMIM: 189940; Uniprot ID:TPR_HUMAN; ENSEMBL ID: ENSG00000047410; HGNC ID: 12017
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst6 / 6231996
fetus37 / 56401265
neonate1 / 3109732
infant1 / 2362042
juvenile1 / 5555617
adult190 / 193912197
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma4 / 17475228
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor20 / 119369167
germ cell tumor24 / 26384590
glioma4 / 10688337
head and neck tumor33 / 136302242
kidney tumor4 / 6895958
leukemia10 / 95842104
liver tumor9 / 9635993
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal223 / 336030766
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor10 / 12494980
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder2 / 2975767
blood13 / 123478105
bone6 / 7165583
bone marrow13 / 48801266
brain35 / 110098931
cervix0 / 481710 
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue21 / 21572297
esophagus3 / 20209148
eye13 / 21105461
heart5 / 8962655
intestine17 / 23447272
kidney12 / 21177756
larynx24 / 24145993
liver20 / 20774396
lung24 / 33697471
lymph1 / 4427022
lymph node14 / 91610152
mammary gland17 / 153271110
mouth4 / 6705259
muscle6 / 10771555
nerve1 / 1576863
ovary2 / 10205119
pancreas10 / 21481246
parathyroid3 / 20539146
pharynx5 / 41328120
pituitary gland1 / 1658560
placenta21 / 28082574
prostate8 / 18934542
salivary gland0 / 201550 
skin13 / 21057461
spleen0 / 539520 
stomach19 / 96619196
testis21 / 33044263
thymus7 / 8113186
thyroid7 / 47473147
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus15 / 23287864
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215220_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.1
Adipocyte10.4
AdrenalCortex20.8
Adrenalgland10.8
Amygdala9.85
Appendix22.2
AtrioventricularNode20.2
BDCA4+_DentriticCells10.55
Bonemarrow14.4
BronchialEpithelialCells9.95
CD105+_Endothelial13.8
CD14+_Monocytes12.6
CD19+_BCells(neg._sel.)11.05
CD33+_Myeloid12.75
CD34+12.8
CD4+_Tcells10.55
CD56+_NKCells15.15
CD71+_EarlyErythroid11.15
CD8+_Tcells9.7
CardiacMyocytes33.65
Caudatenucleus9.7
Cerebellum9.25
CerebellumPeduncles15.55
CiliaryGanglion19.55
CingulateCortex12.45
Colorectaladenocarcinoma10.6
DorsalRootGanglion14.15
FetalThyroid14.9
Fetalbrain9.9
Fetalliver9.85
Fetallung7.2
GlobusPallidus10.9
Heart25.6
Hypothalamus10.1
Kidney11.1
Leukemia_chronicMyelogenousK-5629.55
Leukemia_promyelocytic-HL-609.5
Leukemialymphoblastic(MOLT-4)7.65
Liver21.4
Lung11.7
Lymphnode8.3
Lymphoma_burkitts(Daudi)15.7
Lymphoma_burkitts(Raji)18.65
MedullaOblongata9
OccipitalLobe9.5
OlfactoryBulb8.2
Ovary10.6
Pancreas11.15
PancreaticIslet12.4
ParietalLobe14.65
Pituitary13.65
Placenta9.65
Pons12.2
PrefrontalCortex11.45
Prostate11.7
Salivarygland10.35
SkeletalMuscle26.95
Skin16.75
SmoothMuscle12.45
Spinalcord11.15
SubthalamicNucleus12.85
SuperiorCervicalGanglion27.45
TemporalLobe11.65
Testis9
TestisGermCell8.4
TestisIntersitial10.85
TestisLeydigCell13.35
TestisSeminiferousTubule9.85
Thalamus12.2
Thymus7.45
Thyroid11.45
Tongue17.75
Tonsil11.9
Trachea8.7
TrigeminalGanglion22.3
Uterus7.95
UterusCorpus15.1
WholeBlood11.35
Wholebrain7.6
colon10.3
pineal_day12.96
pineal_night12.42
retina12.85
small_intestine9.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P179611
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.56 ± 0.17
Basal Forebrain9.68 ± 0.16
Basal Part of Pons9.49 ± 0.2
Cerebellar Cortex9.74 ± 0.12
Cerebellar Nuclei9.62 ± 0.15
Claustrum9.76 ± 0.17
Epithalamus10.01 ± 0.12
Frontal Lobe9.54 ± 0.17
Globus Pallidus9.91 ± 0.21
Hypothalamus9.64 ± 0.18
Insula9.5 ± 0.11
Limbic Lobe9.53 ± 0.18
Mesencephalon9.67 ± 0.17
Myelencephalon9.61 ± 0.2
Occipital Lobe9.85 ± 0.23
Parietal Lobe9.58 ± 0.16
Pontine Tegmentum9.61 ± 0.22
Striatum9.79 ± 0.22
Subthalamus9.51 ± 0.12
Temporal Lobe9.55 ± 0.14
Thalamus9.66 ± 0.16
White Matter10.12 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TprCBCerebellum35.04
46.16
TprCTXCerebral cortex64.09
60.25
TprHIPHippocampal region53.75
71.69
TprHPFHippocampal formation59.41
64.21
TprHYHypothalamus17.91
15.33
TprLSXLateral septal complex14.79
12.65
TprMBMidbrain26.4
27.2
TprMYMedulla37.14
50.71
TprOLFOlfactory bulb56.82
59.82
TprPPons27.59
36.07
TprPALPallidum19.66
18.43
TprRHPRetrohippocampal region58.25
57
TprsAMYStriatum-like amygdalar nuclei29.64
23.39
TprSTRStriatum26.5
20.79
TprSTRdStriatum dorsal region26.73
21.64
TprSTRvStriatum ventral region30.32
20.75
TprTHThalamus49.22
48.27
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00006408 18 1111 1128 QHLEETTQKAESQLLECK Peptide Atlas
TPR_HUMAN_1025 13 1025 1037 AIESMEQQLSELK PRIDE
TPR_HUMAN_1155 11 1155 1165 QNRLLHDQIEK PRIDE
TPR_HUMAN_1544 11 1544 1554 QQITEKEEKTR PRIDE
TPR_HUMAN_1831 27 1831 1857 TREEEEDSTIEASDQVSDDTVEMPLPK PRIDE
TPR_HUMAN_2 10 2 11 AAVLQQVLER PRIDE
TPR_HUMAN_2132 18 2132 2149 TDGFAEAIHSPQVAGVPR PRIDE
TPR_HUMAN_367 21 367 387 GAILSEEELAAMSPTAAAVAK PRIDE
TPR_HUMAN_440 7 440 446 QREEYER PRIDE
TPR_HUMAN_502 10 502 511 VLLMELEEAR PRIDE
TPR_HUMAN_598 12 598 609 QHQMQLVDSIVR PRIDE
TPR_HUMAN_756 13 756 768 QEQIINTMTQDLR PRIDE
TPR_HUMAN_906 17 906 922 QHLSNMEVQVASQSSQR PRIDE
TPR_HUMAN_943 12 943 954 QTEEQVNDLKER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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