AutismKB 2.0

Annotation Detail for HSP90B1


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Basic Information Top
Gene Symbol:HSP90B1 ( ECGP,GP96,GRP94,TRA1 )
Gene Full Name: heat shock protein 90kDa beta (Grp94), member 1
Band: 12q23.3
Quick LinksEntrez ID:7184; OMIM: 191175; Uniprot ID:ENPL_HUMAN; ENSEMBL ID: ENSG00000166598; HGNC ID: 12028
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body80 / 707611130
blastocyst52 / 62319834
fetus216 / 564012382
neonate41 / 310971318
infant4 / 23620169
juvenile71 / 555561277
adult1112 / 1939121573
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma2 / 17475114
breast (mammary gland) tumor65 / 94178690
cervical tumor9 / 34366261
chondrosarcoma77 / 82823929
colorectal tumor64 / 114246560
esophageal tumor27 / 172901561
gastrointestinal tumor66 / 119369552
germ cell tumor178 / 263845674
glioma51 / 106883477
head and neck tumor118 / 136302865
kidney tumor30 / 68959435
leukemia34 / 95842354
liver tumor108 / 963591120
lung tumor45 / 103127436
lymphoma5 / 7175569
non-neoplasia32 / 97250329
normal1537 / 3360307457
ovarian tumor46 / 76682599
pancreatic tumor51 / 104616487
primitive neuroectodermal tumor of the CNS36 / 125680286
prostate cancer65 / 102680633
retinoblastoma5 / 46356107
skin tumor34 / 124949272
soft tissue/muscle tissue tumor23 / 125191183
uterine tumor86 / 90257952
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland13 / 33197391
ascites19 / 40015474
bladder10 / 29757336
blood70 / 123478566
bone64 / 71655893
bone marrow21 / 48801430
brain338 / 1100989306
cervix10 / 48171207
connective tissue75 / 149255502
ear12 / 16212740
embryonic tissue196 / 215722908
esophagus27 / 202091336
eye46 / 211054217
heart33 / 89626368
intestine125 / 234472533
kidney106 / 211777500
larynx11 / 24145455
liver171 / 207743823
lung160 / 336974474
lymph0 / 442700 
lymph node18 / 91610196
mammary gland125 / 153271815
mouth47 / 67052700
muscle75 / 107715696
nerve6 / 15768380
ovary58 / 102051568
pancreas99 / 214812460
parathyroid4 / 20539194
pharynx44 / 413281064
pituitary gland9 / 16585542
placenta161 / 280825573
prostate104 / 189345549
salivary gland2 / 2015599
skin90 / 210574427
spleen43 / 53952797
stomach57 / 96619589
testis185 / 330442559
thymus23 / 81131283
thyroid42 / 47473884
tonsil1 / 1699958
trachea28 / 52413534
umbilical cord7 / 13680511
uterus139 / 232878596
vascular55 / 517801062
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200599_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts2175.6
Adipocyte951.65
AdrenalCortex756.45
Adrenalgland132.85
Amygdala731.85
Appendix253.95
AtrioventricularNode306.2
BDCA4+_DentriticCells3019.55
Bonemarrow100.75
BronchialEpithelialCells2272
CD105+_Endothelial910.1
CD14+_Monocytes790.85
CD19+_BCells(neg._sel.)1158.75
CD33+_Myeloid921.55
CD34+1670.7
CD4+_Tcells930.55
CD56+_NKCells1243.45
CD71+_EarlyErythroid292.4
CD8+_Tcells1187.1
CardiacMyocytes2307.6
Caudatenucleus436.9
Cerebellum52.1
CerebellumPeduncles155.25
CiliaryGanglion171.45
CingulateCortex302.55
Colorectaladenocarcinoma991.55
DorsalRootGanglion247.85
FetalThyroid2250.85
Fetalbrain306.8
Fetalliver888.1
Fetallung1204.4
GlobusPallidus200.1
Heart19.65
Hypothalamus816.75
Kidney41.95
Leukemia_chronicMyelogenousK-5621842.8
Leukemia_promyelocytic-HL-60451.5
Leukemialymphoblastic(MOLT-4)361.25
Liver62.3
Lung23.45
Lymphnode1135.15
Lymphoma_burkitts(Daudi)631
Lymphoma_burkitts(Raji)439.05
MedullaOblongata335.15
OccipitalLobe487.7
OlfactoryBulb1306.55
Ovary850.4
Pancreas1058.1
PancreaticIslet1847.35
ParietalLobe329.4
Pituitary2545.85
Placenta877.25
Pons265.25
PrefrontalCortex623
Prostate619.45
Salivarygland710.85
SkeletalMuscle33.2
Skin148.5
SmoothMuscle3770.85
Spinalcord616.2
SubthalamicNucleus213.9
SuperiorCervicalGanglion123.25
TemporalLobe245.55
Testis113.9
TestisGermCell849.1
TestisIntersitial535.85
TestisLeydigCell657.55
TestisSeminiferousTubule444.9
Thalamus484.25
Thymus142.5
Thyroid6304.5
Tongue251.7
Tonsil573.9
Trachea506.95
TrigeminalGanglion337.8
Uterus956.25
UterusCorpus408.55
WholeBlood536.85
Wholebrain150.6
colon834.5
pineal_day1314.68
pineal_night1416.84
retina348.175
small_intestine692.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P150361
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.56 ± 0.47
Basal Forebrain8.9 ± 0.29
Basal Part of Pons8.78 ± 0.29
Cerebellar Cortex8.58 ± 0.22
Cerebellar Nuclei9.08 ± 0.21
Claustrum8.48 ± 0.49
Epithalamus9.54 ± 0.21
Frontal Lobe8.99 ± 0.29
Globus Pallidus9.22 ± 0.19
Hypothalamus9.39 ± 0.29
Insula9.06 ± 0.3
Limbic Lobe8.71 ± 0.44
Mesencephalon8.87 ± 0.28
Myelencephalon8.88 ± 0.4
Occipital Lobe8.58 ± 0.41
Parietal Lobe8.86 ± 0.36
Pontine Tegmentum9.02 ± 0.34
Striatum9.13 ± 0.3
Subthalamus9.3 ± 0.09
Temporal Lobe8.95 ± 0.36
Thalamus8.9 ± 0.29
White Matter9.88 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hsp90b1CBCerebellum100
100
Hsp90b1CTXCerebral cortex100
100
Hsp90b1HIPHippocampal region100
100
Hsp90b1HPFHippocampal formation100
100
Hsp90b1HYHypothalamus100
100
Hsp90b1LSXLateral septal complex100
100
Hsp90b1MBMidbrain100
100
Hsp90b1MYMedulla100
100
Hsp90b1OLFOlfactory bulb100
100
Hsp90b1PPons100
100
Hsp90b1PALPallidum100
100
Hsp90b1RHPRetrohippocampal region100
100
Hsp90b1sAMYStriatum-like amygdalar nuclei100
100
Hsp90b1STRStriatum100
100
Hsp90b1STRdStriatum dorsal region100
100
Hsp90b1STRvStriatum ventral region100
100
Hsp90b1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ENPL_HUMAN_0 0 0 0 EGVKFDESEKTK PRIDE
ENPL_HUMAN_0 0 0 0 FQSSHHPTDITSLDQYVER PRIDE
ENPL_HUMAN_0 0 0 0 GVVDSDDLPLNVSR PRIDE
ENPL_HUMAN_0 0 0 0 SILFVPTSAPR PRIDE
ENPL_HUMAN_102 12 102 113 ELISNASDALDK PRIDE
ENPL_HUMAN_102 14 102 115 ELISNASDALDKIR PRIDE
ENPL_HUMAN_103 12 103 114 ELISNASDALDK PRIDE
ENPL_HUMAN_116 19 116 134 LISLTDENALSGNEELTVK PRIDE
ENPL_HUMAN_117 19 117 135 LISLTDENALSGNEELTVK PRIDE
ENPL_HUMAN_142 14 142 155 NLLHVTDTGVGMTR PRIDE
ENPL_HUMAN_142 19 142 160 NLLHVTDTGVGMTREELVK PRIDE
ENPL_HUMAN_142 26 142 167 NLLHVTDTGVGMTREELVKNLGTIAK PRIDE
ENPL_HUMAN_169 9 169 177 SGTSEFLNK PRIDE
ENPL_HUMAN_22 18 22 39 DDEVDVDGTVEEDLGKSR PRIDE
ENPL_HUMAN_243 22 243 264 GTTITLVLKEEASDYLELDTIK PRIDE
ENPL_HUMAN_253 13 253 265 EEASDYLELDTIK PRIDE
ENPL_HUMAN_269 16 269 284 KYSQFINFPIYVWSSK PRIDE
ENPL_HUMAN_270 15 270 284 YSQFINFPIYVWSSK PRIDE
ENPL_HUMAN_286 15 286 300 TETVEEPMEEEEAAK PRIDE
ENPL_HUMAN_29 11 29 39 GTVEEDLGKSR PRIDE
ENPL_HUMAN_300 22 300 321 EEKEESDDEAAVEEEEEEKKPK PRIDE
ENPL_HUMAN_303 19 303 321 EESDDEAAVEEEEEEKKPK PRIDE
ENPL_HUMAN_328 20 328 347 TVWDWELMNDIKPIWQRPSK PRIDE
ENPL_HUMAN_328 28 328 355 TVWDWELMNDIKPIWQRPSKEVEEDEYK PRIDE
ENPL_HUMAN_349 12 349 360 EVEEDEYKAFYK PRIDE
ENPL_HUMAN_364 20 364 383 ESDDPMAYIHFTAEGEVTFK PRIDE
ENPL_HUMAN_384 11 384 394 SILFVPTSAPR PRIDE
ENPL_HUMAN_385 11 385 395 SILFVPTSAPR PRIDE
ENPL_HUMAN_39 28 39 66 EGSRTDDEVVQREEEAIQLDGLNASQIR PRIDE
ENPL_HUMAN_395 9 395 403 GLFDEYGSK PRIDE
ENPL_HUMAN_396 9 396 404 GLFDEYGSK PRIDE
ENPL_HUMAN_414 14 414 427 RVFITDDFHDMMPK PRIDE
ENPL_HUMAN_415 13 415 427 VFITDDFHDMMPK PRIDE
ENPL_HUMAN_415 14 415 428 RVFITDDFHDMMPK PRIDE
ENPL_HUMAN_416 13 416 428 VFITDDFHDMMPK PRIDE
ENPL_HUMAN_434 14 434 447 GVVDSDDLPLNVSR PRIDE
ENPL_HUMAN_435 14 435 448 GVVDSDDLPLNVSR PRIDE
ENPL_HUMAN_44 24 44 67 TDDEVVQREEEAIQLDGLNASQIR PRIDE
ENPL_HUMAN_44 8 44 51 TDDEVVQR PRIDE
ENPL_HUMAN_473 13 473 485 KIADDKYNDTFWK PRIDE
ENPL_HUMAN_474 19 474 492 IADDKYNDTFWKEFGTNIK PRIDE
ENPL_HUMAN_494 10 494 503 LGVIEDHSNR PRIDE
ENPL_HUMAN_511 19 511 529 FQSSHHPTDITSLDQYVER PRIDE
ENPL_HUMAN_512 19 512 530 FQSSHHPTDITSLDQYVER PRIDE
ENPL_HUMAN_52 16 52 67 EEEAIQLDGLNASQIR PRIDE
ENPL_HUMAN_534 13 534 546 QDKIYFMAGSSRK PRIDE
ENPL_HUMAN_537 9 537 545 IYFMAGSSR PRIDE
ENPL_HUMAN_538 9 538 546 IYFMAGSSR PRIDE
ENPL_HUMAN_547 11 547 557 KEAESSPFVER PRIDE
ENPL_HUMAN_548 10 548 557 EAESSPFVER PRIDE
ENPL_HUMAN_560 27 560 586 KGYEVIYLTEPVDEYCIQALPEFDGKR PRIDE
ENPL_HUMAN_593 12 593 604 EGVKFDESEKTK PRIDE
ENPL_HUMAN_608 15 608 622 EAVEKEFEPLLNWMK PRIDE
ENPL_HUMAN_608 17 608 624 EAVEKEFEPLLNWMKDK PRIDE
ENPL_HUMAN_613 10 613 622 EFEPLLNWMK PRIDE
ENPL_HUMAN_614 10 614 623 EFEPLLNWMK PRIDE
ENPL_HUMAN_639 21 639 659 LTESPCALVASQYGWSGNMER PRIDE
ENPL_HUMAN_663 19 663 681 AQAYQTGKDISTNYYASQK PRIDE
ENPL_HUMAN_663 20 663 682 AQAYQTGKDISTNYYASQKK PRIDE
ENPL_HUMAN_671 11 671 681 DISTNYYASQK PRIDE
ENPL_HUMAN_672 11 672 682 DISTNYYASQK PRIDE
ENPL_HUMAN_683 7 683 689 TFEINPR PRIDE
ENPL_HUMAN_684 7 684 690 TFEINPR PRIDE
ENPL_HUMAN_700 24 700 723 IKEDEDDKTVLDLAVVLFETATLR PRIDE
ENPL_HUMAN_724 9 724 732 SGYLLPDTK PRIDE
ENPL_HUMAN_725 14 725 738 SGYLLPDTKAYGDR PRIDE
ENPL_HUMAN_725 9 725 733 SGYLLPDTK PRIDE
ENPL_HUMAN_744 10 744 753 LSLNIDPDAK PRIDE
ENPL_HUMAN_75 9 75 83 FAFQAEVNR PRIDE
ENPL_HUMAN_87 8 87 94 LIINSLYK PRIDE
PAp00002547 19 512 530 FQSSHHPTDITSLDQYVER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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