AutismKB 2.0

Annotation Detail for TRIO


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Basic Information Top
Gene Symbol:TRIO ( ARHGEF23,FLJ42780,tgat )
Gene Full Name: triple functional domain (PTPRF interacting)
Band: 5p15.2
Quick LinksEntrez ID:7204; OMIM: 601893; Uniprot ID:TRIO_HUMAN; ENSEMBL ID: ENSG00000038382; HGNC ID: 12303
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst10 / 62319160
fetus55 / 56401297
neonate1 / 3109732
infant1 / 2362042
juvenile0 / 555560 
adult193 / 193912199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor21 / 94178222
cervical tumor3 / 3436687
chondrosarcoma20 / 82823241
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor20 / 26384575
glioma17 / 106883159
head and neck tumor15 / 136302110
kidney tumor6 / 6895987
leukemia9 / 9584293
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal284 / 336030784
ovarian tumor8 / 76682104
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer8 / 10268077
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder1 / 2975733
blood5 / 12347840
bone18 / 71655251
bone marrow1 / 4880120
brain72 / 110098965
cervix3 / 4817162
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus0 / 202090 
eye24 / 211054113
heart7 / 8962678
intestine23 / 23447298
kidney19 / 21177789
larynx3 / 24145124
liver20 / 20774396
lung34 / 336974100
lymph1 / 4427022
lymph node25 / 91610272
mammary gland28 / 153271182
mouth9 / 67052134
muscle6 / 10771555
nerve2 / 15768126
ovary9 / 10205188
pancreas27 / 214812125
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland5 / 16585301
placenta10 / 28082535
prostate10 / 18934552
salivary gland0 / 201550 
skin18 / 21057485
spleen0 / 539520 
stomach11 / 96619113
testis9 / 33044227
thymus1 / 8113112
thyroid5 / 47473105
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209010_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.15
Adipocyte4.15
AdrenalCortex4.55
Adrenalgland3.6
Amygdala4.35
Appendix4.45
AtrioventricularNode3.3
BDCA4+_DentriticCells4.55
Bonemarrow4.25
BronchialEpithelialCells4.15
CD105+_Endothelial4.2
CD14+_Monocytes4.45
CD19+_BCells(neg._sel.)4.45
CD33+_Myeloid5.35
CD34+5.25
CD4+_Tcells4.45
CD56+_NKCells4.9
CD71+_EarlyErythroid3.95
CD8+_Tcells4
CardiacMyocytes5.6
Caudatenucleus3.8
Cerebellum3.5
CerebellumPeduncles4.95
CiliaryGanglion3.15
CingulateCortex4.3
Colorectaladenocarcinoma4.2
DorsalRootGanglion3.3
FetalThyroid4.1
Fetalbrain4.1
Fetalliver3.7
Fetallung3.4
GlobusPallidus3.15
Heart5.6
Hypothalamus4.55
Kidney3.55
Leukemia_chronicMyelogenousK-5623.8
Leukemia_promyelocytic-HL-603.7
Leukemialymphoblastic(MOLT-4)3.35
Liver5.7
Lung4.6
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)6
MedullaOblongata3.8
OccipitalLobe3.75
OlfactoryBulb3.3
Ovary2.8
Pancreas3.4
PancreaticIslet4.6
ParietalLobe4.75
Pituitary4.85
Placenta4.25
Pons4
PrefrontalCortex5.15
Prostate5.2
Salivarygland3.35
SkeletalMuscle5.5
Skin3.35
SmoothMuscle4.75
Spinalcord4.5
SubthalamicNucleus3.85
SuperiorCervicalGanglion5.05
TemporalLobe3.85
Testis3.6
TestisGermCell3.5
TestisIntersitial3.5
TestisLeydigCell4.2
TestisSeminiferousTubule3.55
Thalamus4.35
Thymus3.25
Thyroid5.2
Tongue4.25
Tonsil4.1
Trachea3.5
TrigeminalGanglion4.35
Uterus3.4
UterusCorpus14.2
WholeBlood4.55
Wholebrain3.5
colon4.15
pineal_day5.2
pineal_night5.12
retina5.075
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P425880
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.36 ± 0.41
Basal Forebrain9.23 ± 0.12
Basal Part of Pons9.16 ± 0.21
Cerebellar Cortex9.57 ± 0.21
Cerebellar Nuclei8.75 ± 0.42
Claustrum9.23 ± 0.29
Epithalamus8.75 ± 0.33
Frontal Lobe9.13 ± 0.33
Globus Pallidus8.41 ± 0.22
Hypothalamus8.77 ± 0.3
Insula9.28 ± 0.32
Limbic Lobe9.57 ± 0.41
Mesencephalon9.09 ± 0.41
Myelencephalon9.23 ± 0.33
Occipital Lobe9.8 ± 0.38
Parietal Lobe9.29 ± 0.32
Pontine Tegmentum9.18 ± 0.38
Striatum8.76 ± 0.32
Subthalamus8.44 ± 0.5
Temporal Lobe9.49 ± 0.25
Thalamus9.33 ± 0.33
White Matter7.97 ± 0.29
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00073350 7 2877 2883 LLDCVVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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