AutismKB 2.0

Annotation Detail for TRO


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Basic Information Top
Gene Symbol:TRO ( KIAA1114,MAGE-d3,MAGED3 )
Gene Full Name: trophinin
Band: Xp11.21
Quick LinksEntrez ID:7216; OMIM: 300132; Uniprot ID:TROP_HUMAN; ENSEMBL ID: ENSG00000067445; HGNC ID: 12326
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst14 / 62319224
fetus98 / 564012173
neonate1 / 3109732
infant0 / 236200 
juvenile6 / 55556107
adult130 / 193912167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor91 / 263845344
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor7 / 68959101
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal423 / 3360307125
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor9 / 12494972
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain343 / 1100989311
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue27 / 215722125
esophagus0 / 202090 
eye5 / 21105423
heart4 / 8962644
intestine2 / 2344728
kidney11 / 21177751
larynx0 / 241450 
liver3 / 20774314
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth2 / 6705229
muscle4 / 10771537
nerve1 / 1576863
ovary1 / 1020519
pancreas7 / 21481232
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate5 / 18934526
salivary gland0 / 201550 
skin12 / 21057456
spleen1 / 5395218
stomach1 / 9661910
testis71 / 330442214
thymus58 / 81131714
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord1 / 1368073
uterus34 / 232878145
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211700_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte3.7
AdrenalCortex3.9
Adrenalgland3.15
Amygdala19.8
Appendix3.75
AtrioventricularNode2.8
BDCA4+_DentriticCells4.65
Bonemarrow3.7
BronchialEpithelialCells3.65
CD105+_Endothelial3.85
CD14+_Monocytes4
CD19+_BCells(neg._sel.)3.95
CD33+_Myeloid4.75
CD34+13.1
CD4+_Tcells4
CD56+_NKCells4.45
CD71+_EarlyErythroid3.55
CD8+_Tcells3.6
CardiacMyocytes4.9
Caudatenucleus3.4
Cerebellum3
CerebellumPeduncles4.3
CiliaryGanglion2.65
CingulateCortex6.4
Colorectaladenocarcinoma3.75
DorsalRootGanglion2.85
FetalThyroid3.65
Fetalbrain76.65
Fetalliver3.3
Fetallung7.1
GlobusPallidus8
Heart4.75
Hypothalamus44.3
Kidney3
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3
Liver4.9
Lung4.1
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.8
Lymphoma_burkitts(Raji)5.25
MedullaOblongata4.4
OccipitalLobe5.75
OlfactoryBulb3.6
Ovary2.45
Pancreas3
PancreaticIslet4
ParietalLobe4.35
Pituitary4.4
Placenta3.8
Pons3.6
PrefrontalCortex22.6
Prostate4.35
Salivarygland3
SkeletalMuscle4.4
Skin2.9
SmoothMuscle4.25
Spinalcord4.15
SubthalamicNucleus4.45
SuperiorCervicalGanglion4.25
TemporalLobe3.45
Testis3.2
TestisGermCell3.15
TestisIntersitial3.1
TestisLeydigCell3.65
TestisSeminiferousTubule3.15
Thalamus8.35
Thymus2.95
Thyroid5.75
Tongue3.65
Tonsil3.6
Trachea3.1
TrigeminalGanglion4.55
Uterus8.35
UterusCorpus3.7
WholeBlood4.05
Wholebrain12.15
colon3.75
pineal_day11.92
pineal_night19.64
retina5.1
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16765_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.25 ± 0.39
Basal Forebrain4.94 ± 0.56
Basal Part of Pons5.74 ± 0.51
Cerebellar Cortex4.98 ± 0.51
Cerebellar Nuclei4.77 ± 0.74
Claustrum4.72 ± 0.95
Epithalamus4.89 ± 0.4
Frontal Lobe5.44 ± 0.52
Globus Pallidus4.73 ± 0.59
Hypothalamus6.02 ± 0.92
Insula5.54 ± 0.43
Limbic Lobe5.34 ± 0.62
Mesencephalon5.1 ± 0.6
Myelencephalon5.1 ± 0.71
Occipital Lobe4.47 ± 0.79
Parietal Lobe5.22 ± 0.55
Pontine Tegmentum5.02 ± 0.65
Striatum4.44 ± 0.8
Subthalamus4.68 ± 0.52
Temporal Lobe5.43 ± 0.54
Thalamus5.05 ± 0.52
White Matter4.06 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TroCBCerebellum18.57
19.98
TroCTXCerebral cortex100
96.79
TroHIPHippocampal region69.54
100
TroHPFHippocampal formation84.1
100
TroHYHypothalamus100
100
TroLSXLateral septal complex100
100
TroMBMidbrain100
100
TroMYMedulla79.39
91.97
TroOLFOlfactory bulb96.83
95.76
TroPPons88.05
97.74
TroPALPallidum100
100
TroRHPRetrohippocampal region100
100
TrosAMYStriatum-like amygdalar nuclei100
100
TroSTRStriatum99.65
94.97
TroSTRdStriatum dorsal region75.96
62.04
TroSTRvStriatum ventral region100
98.5
TroTHThalamus82.39
83.94
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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