AutismKB 2.0

Annotation Detail for TRPC4


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Basic Information Top
Gene Symbol:TRPC4 ( HTRP4,MGC119570,MGC119571,MGC119572,MGC119573,TRP4 )
Gene Full Name: transient receptor potential cation channel, subfamily C, member 4
Band: 13q13.3
Quick LinksEntrez ID:7223; OMIM: 603651; Uniprot ID:TRPC4_HUMAN; ENSEMBL ID: ENSG00000133107; HGNC ID: 12336
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult9 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal28 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain11 / 11009899
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus16 / 23287868
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220818_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte6.6
AdrenalCortex7.85
Adrenalgland5.9
Amygdala6.8
Appendix12
AtrioventricularNode6.5
BDCA4+_DentriticCells6.85
Bonemarrow7.05
BronchialEpithelialCells6.55
CD105+_Endothelial6.9
CD14+_Monocytes7.35
CD19+_BCells(neg._sel.)7
CD33+_Myeloid8.35
CD34+7.85
CD4+_Tcells7.05
CD56+_NKCells7.8
CD71+_EarlyErythroid6.35
CD8+_Tcells6.2
CardiacMyocytes10.2
Caudatenucleus6.1
Cerebellum5.45
CerebellumPeduncles8.25
CiliaryGanglion5.45
CingulateCortex16.55
Colorectaladenocarcinoma6.6
DorsalRootGanglion7.6
FetalThyroid6.8
Fetalbrain6.65
Fetalliver5.95
Fetallung5.35
GlobusPallidus10.2
Heart9.2
Hypothalamus7.2
Kidney5.9
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.95
Leukemialymphoblastic(MOLT-4)6.25
Liver9.2
Lung7.1
Lymphnode5.6
Lymphoma_burkitts(Daudi)8.65
Lymphoma_burkitts(Raji)9.45
MedullaOblongata6
OccipitalLobe5.95
OlfactoryBulb5.55
Ovary4.75
Pancreas5.75
PancreaticIslet7.25
ParietalLobe9.95
Pituitary7.8
Placenta6.75
Pons6.8
PrefrontalCortex8.2
Prostate7.7
Salivarygland6
SkeletalMuscle13.9
Skin7.1
SmoothMuscle7.5
Spinalcord18.45
SubthalamicNucleus8.65
SuperiorCervicalGanglion8.4
TemporalLobe8.2
Testis7.5
TestisGermCell5.55
TestisIntersitial5.65
TestisLeydigCell6.8
TestisSeminiferousTubule5.75
Thalamus6.95
Thymus5.1
Thyroid8
Tongue8.3
Tonsil6.7
Trachea5.6
TrigeminalGanglion7.4
Uterus5.5
UterusCorpus6.35
WholeBlood7.2
Wholebrain5.45
colon6.7
pineal_day8.22
pineal_night7.94
retina8
small_intestine6.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15178_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.89 ± 0.84
Basal Forebrain5.58 ± 0.63
Basal Part of Pons3.85 ± 0.49
Cerebellar Cortex4.13 ± 0.7
Cerebellar Nuclei3.84 ± 0.39
Claustrum6.03 ± 0.92
Epithalamus3.86 ± 0.4
Frontal Lobe4.57 ± 0.64
Globus Pallidus4.34 ± 1.03
Hypothalamus4.55 ± 0.71
Insula5.29 ± 0.4
Limbic Lobe5.4 ± 0.64
Mesencephalon4.6 ± 0.67
Myelencephalon4.65 ± 0.82
Occipital Lobe4.37 ± 0.69
Parietal Lobe4.82 ± 0.72
Pontine Tegmentum4.74 ± 0.72
Striatum4.18 ± 1.12
Subthalamus3.83 ± 0.64
Temporal Lobe5.01 ± 0.66
Thalamus3.82 ± 0.75
White Matter2.55 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Trpc4CBCerebellum7.18
6.52
Trpc4CTXCerebral cortex21.25
14.34
Trpc4HIPHippocampal region54.62
61.13
Trpc4HPFHippocampal formation57.22
60.02
Trpc4HYHypothalamus11.33
6.93
Trpc4LSXLateral septal complex100
100
Trpc4MBMidbrain6.56
5.35
Trpc4MYMedulla7.25
5.73
Trpc4OLFOlfactory bulb42.9
25.21
Trpc4PPons5.83
4.21
Trpc4PALPallidum17.18
12.78
Trpc4RHPRetrohippocampal region62.26
58.88
Trpc4sAMYStriatum-like amygdalar nuclei22.98
12.93
Trpc4STRStriatum19.75
16.62
Trpc4STRdStriatum dorsal region5.09
3.73
Trpc4STRvStriatum ventral region9.21
5.55
Trpc4THThalamus6.13
3.93
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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