Annotation Detail for TRPM2
Basic Information Top
| Gene Symbol: | TRPM2 ( EREG1,KNP3,LTRPC2,MGC133383,NUDT9H,NUDT9L1,TRPC7 ) |
|---|---|
| Gene Full Name: | transient receptor potential cation channel, subfamily M, member 2 |
| Band: | 21q22.3 |
| Quick Links | Entrez ID:7226; OMIM: 603749; Uniprot ID:TRPM2_HUMAN; ENSEMBL ID: ENSG00000142185; HGNC ID: 12339 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.369759
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 0 / 564012 | 0 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 32 / 1939121 | 16 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 |  |
| breast (mammary gland) tumor | 1 / 94178 | 10 |  |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 6 / 119369 | 50 | |
| germ cell tumor | 5 / 263845 | 18 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 3 / 95842 | 31 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 33 / 3360307 | 9 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 4 / 102680 | 38 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 4 / 40015 | 99 | |
| bladder | 1 / 29757 | 33 | |
| blood | 3 / 123478 | 24 | |
| bone | 3 / 71655 | 41 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 19 / 1100989 | 17 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 2 / 149255 | 13 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 2 / 211054 | 9 | |
| heart | 0 / 89626 | 0 | |
| intestine | 7 / 234472 | 29 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 2 / 336974 | 5 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 1 / 153271 | 6 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 2 / 280825 | 7 | |
| prostate | 4 / 189345 | 21 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 1 / 210574 | 4 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 2 / 96619 | 20 | |
| testis | 4 / 330442 | 12 | |
| thymus | 1 / 81131 | 12 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 1 / 232878 | 4 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 205708_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6.05 | |
| Adipocyte | 4.85 | |
| AdrenalCortex | 5.4 | |
| Adrenalgland | 4.25 | |
| Amygdala | 5.7 | |
| Appendix | 5.05 | |
| AtrioventricularNode | 4.25 | |
| BDCA4+_DentriticCells | 21.5 | |
| Bonemarrow | 8.55 | |
| BronchialEpithelialCells | 4.65 | |
| CD105+_Endothelial | 5.15 | |
| CD14+_Monocytes | 7.5 | |
| CD19+_BCells(neg._sel.) | 5.5 | |
| CD33+_Myeloid | 6.7 | |
| CD34+ | 8.75 | |
| CD4+_Tcells | 5.65 | |
| CD56+_NKCells | 6.2 | |
| CD71+_EarlyErythroid | 4.9 | |
| CD8+_Tcells | 5.05 | |
| CardiacMyocytes | 6.65 | |
| Caudatenucleus | 5.85 | |
| Cerebellum | 4.2 | |
| CerebellumPeduncles | 5.75 | |
| CiliaryGanglion | 3.5 | |
| CingulateCortex | 5.3 | |
| Colorectaladenocarcinoma | 5.7 | |
| DorsalRootGanglion | 3.9 | |
| FetalThyroid | 4.95 | |
| Fetalbrain | 5.15 | |
| Fetalliver | 4.45 | |
| Fetallung | 4.3 | |
| GlobusPallidus | 3.75 | |
| Heart | 7.65 | |
| Hypothalamus | 5.65 | |
| Kidney | 4.15 | |
| Leukemia_chronicMyelogenousK-562 | 4.6 | |
| Leukemia_promyelocytic-HL-60 | 4.5 | |
| Leukemialymphoblastic(MOLT-4) | 4.15 | |
| Liver | 6.7 | |
| Lung | 5.6 | |
| Lymphnode | 4.45 | |
| Lymphoma_burkitts(Daudi) | 6.45 | |
| Lymphoma_burkitts(Raji) | 8.65 | |
| MedullaOblongata | 5.9 | |
| OccipitalLobe | 4.7 | |
| OlfactoryBulb | 3.9 | |
| Ovary | 3.35 | |
| Pancreas | 4.15 | |
| PancreaticIslet | 5.45 | |
| ParietalLobe | 8.65 | |
| Pituitary | 5.95 | |
| Placenta | 5.3 | |
| Pons | 4.85 | |
| PrefrontalCortex | 10.1 | |
| Prostate | 5.95 | |
| Salivarygland | 4.1 | |
| SkeletalMuscle | 6 | |
| Skin | 3.95 | |
| SmoothMuscle | 5.85 | |
| Spinalcord | 8.5 | |
| SubthalamicNucleus | 4.6 | |
| SuperiorCervicalGanglion | 5.8 | |
| TemporalLobe | 4.65 | |
| Testis | 4.85 | |
| TestisGermCell | 4.2 | |
| TestisIntersitial | 4.25 | |
| TestisLeydigCell | 5 | |
| TestisSeminiferousTubule | 4.4 | |
| Thalamus | 9.5 | |
| Thymus | 4 | |
| Thyroid | 6.4 | |
| Tongue | 5 | |
| Tonsil | 5 | |
| Trachea | 4.25 | |
| TrigeminalGanglion | 5.15 | |
| Uterus | 4.2 | |
| UterusCorpus | 4.5 | |
| WholeBlood | 5.55 | |
| Wholebrain | 4.4 | |
| colon | 6.9 | |
| pineal_day | 6.42 | |
| pineal_night | 6.28 | |
| retina | 6.225 | |
| small_intestine | 6.4 | |
- Probe name: A_24_P322756
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.34 ± 0.82 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.82 ± 0.52 | |
| Basal Part of Pons | 3.61 ± 0.64 | |
| Cerebellar Cortex | 3.57 ± 0.59 | |
| Cerebellar Nuclei | 3.24 ± 0.6 | |
| Claustrum | 3.14 ± 0.74 | |
| Epithalamus | 2.79 ± 0.84 | |
| Frontal Lobe | 3.44 ± 0.67 | |
| Globus Pallidus | 2.14 ± 0.67 | |
| Hypothalamus | 3.07 ± 0.54 | |
| Insula | 3.17 ± 0.48 | |
| Limbic Lobe | 3.13 ± 0.65 | |
| Mesencephalon | 3.23 ± 0.68 | |
| Myelencephalon | 3.24 ± 0.67 | |
| Occipital Lobe | 3.02 ± 0.72 | |
| Parietal Lobe | 3.27 ± 0.64 | |
| Pontine Tegmentum | 3.17 ± 0.65 | |
| Striatum | 3.26 ± 0.59 | |
| Subthalamus | 3.04 ± 0.86 | |
| Temporal Lobe | 3.24 ± 0.59 | |
| Thalamus | 3.31 ± 0.7 | |
| White Matter | 1.24 ± 0.74 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Trpm2 | CB | Cerebellum | 36.15 | |
| 48.26 | | |||
| Trpm2 | CTX | Cerebral cortex | 54.49 | |
| 42.12 | | |||
| Trpm2 | HIP | Hippocampal region | 27.11 | |
| 29.13 | | |||
| Trpm2 | HPF | Hippocampal formation | 40.39 | |
| 38.54 | | |||
| Trpm2 | HY | Hypothalamus | 36.48 | |
| 27.82 | | |||
| Trpm2 | LSX | Lateral septal complex | 48.56 | |
| 33.01 | | |||
| Trpm2 | MB | Midbrain | 54.88 | |
| 52.34 | | |||
| Trpm2 | MY | Medulla | 61.73 | |
| 72.79 | | |||
| Trpm2 | OLF | Olfactory bulb | 63.19 | |
| 51.21 | | |||
| Trpm2 | P | Pons | 50.84 | |
| 56.7 | | |||
| Trpm2 | PAL | Pallidum | 48.77 | |
| 48.79 | | |||
| Trpm2 | RHP | Retrohippocampal region | 69.24 | |
| 56.96 | | |||
| Trpm2 | sAMY | Striatum-like amygdalar nuclei | 37.72 | |
| 26.76 | | |||
| Trpm2 | STR | Striatum | 32.24 | |
| 22.07 | | |||
| Trpm2 | STRd | Striatum dorsal region | 26.15 | |
| 17.83 | | |||
| Trpm2 | STRv | Striatum ventral region | 44.51 | |
| 29.35 | | |||
| Trpm2 | TH | Thalamus | 78.7 | |
| 73.89 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| TRPM2_HUMAN_23 | 12 | 23 | 34 | RVTDLGMVSNLR | PRIDE |