AutismKB 2.0

Annotation Detail for C5


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Basic Information Top
Gene Symbol:C5 ( CPAMD4,FLJ17816,FLJ17822,MGC142298 )
Gene Full Name: complement component 5
Band: 9q33.2
Quick LinksEntrez ID:727; OMIM: 120900; Uniprot ID:CO5_HUMAN; ENSEMBL ID: ENSG00000106804; HGNC ID: 1331
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile7 / 55556125
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor15 / 96359155
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal87 / 336030725
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow1 / 4880120
brain6 / 11009895
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney6 / 21177728
larynx0 / 241450 
liver59 / 207743284
lung7 / 33697420
lymph1 / 4427022
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205500_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.45
Adipocyte10.2
AdrenalCortex16.7
Adrenalgland9
Amygdala11.15
Appendix14.75
AtrioventricularNode9.9
BDCA4+_DentriticCells9.1
Bonemarrow11.5
BronchialEpithelialCells10.2
CD105+_Endothelial10
CD14+_Monocytes10.85
CD19+_BCells(neg._sel.)9.85
CD33+_Myeloid13.15
CD34+15.25
CD4+_Tcells9.6
CD56+_NKCells11.35
CD71+_EarlyErythroid9.85
CD8+_Tcells8.3
CardiacMyocytes13.15
Caudatenucleus10.95
Cerebellum9.55
CerebellumPeduncles12.1
CiliaryGanglion8.2
CingulateCortex10.9
Colorectaladenocarcinoma10.2
DorsalRootGanglion11.35
FetalThyroid10.4
Fetalbrain10.3
Fetalliver503.95
Fetallung20.75
GlobusPallidus8.05
Heart15.85
Hypothalamus12.3
Kidney9.75
Leukemia_chronicMyelogenousK-5629.4
Leukemia_promyelocytic-HL-609.45
Leukemialymphoblastic(MOLT-4)7.95
Liver42.35
Lung10.5
Lymphnode8.3
Lymphoma_burkitts(Daudi)13.95
Lymphoma_burkitts(Raji)14.95
MedullaOblongata13.05
OccipitalLobe10.35
OlfactoryBulb8.25
Ovary7.55
Pancreas14.05
PancreaticIslet22.85
ParietalLobe14.3
Pituitary12.6
Placenta9.15
Pons18.1
PrefrontalCortex12.85
Prostate10.9
Salivarygland10.1
SkeletalMuscle20.5
Skin12.6
SmoothMuscle11.1
Spinalcord14.4
SubthalamicNucleus9.9
SuperiorCervicalGanglion19.45
TemporalLobe12.3
Testis8.95
TestisGermCell10.45
TestisIntersitial8.65
TestisLeydigCell10.8
TestisSeminiferousTubule10.95
Thalamus10.85
Thymus7.65
Thyroid11.7
Tongue13.2
Tonsil10.1
Trachea9
TrigeminalGanglion14.85
Uterus7.65
UterusCorpus9.8
WholeBlood10.6
Wholebrain7.95
colon10.1
pineal_day12.58
pineal_night11.54
retina14.875
small_intestine9.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P71855
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.12 ± 1
Basal Forebrain3.76 ± 0.43
Basal Part of Pons3.57 ± 0.65
Cerebellar Cortex3.48 ± 0.43
Cerebellar Nuclei3.53 ± 0.59
Claustrum3.34 ± 0.59
Epithalamus4.95 ± 0.72
Frontal Lobe3.56 ± 0.64
Globus Pallidus4.63 ± 0.26
Hypothalamus3.6 ± 0.36
Insula3.57 ± 0.49
Limbic Lobe3.52 ± 0.58
Mesencephalon3.91 ± 0.73
Myelencephalon3.72 ± 0.63
Occipital Lobe3.51 ± 0.66
Parietal Lobe3.7 ± 0.63
Pontine Tegmentum3.67 ± 0.56
Striatum4.6 ± 0.43
Subthalamus3.71 ± 0.21
Temporal Lobe3.66 ± 0.51
Thalamus3.75 ± 0.49
White Matter5.25 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
HcCBCerebellum0.39
0.66
HcCTXCerebral cortex0.28
0.27
HcHIPHippocampal region0.22
0.24
HcHPFHippocampal formation0.78
0.83
HcHYHypothalamus0.37
0.61
HcLSXLateral septal complex0.12
0.17
HcMBMidbrain0.22
0.3
HcMYMedulla0.46
0.53
HcOLFOlfactory bulb0.31
0.42
HcPPons0.13
0.21
HcPALPallidum0.56
0.64
HcRHPRetrohippocampal region2
1.94
HcsAMYStriatum-like amygdalar nuclei0.3
0.32
HcSTRStriatum0.16
0.21
HcSTRdStriatum dorsal region0.12
0.14
HcSTRvStriatum ventral region0.21
0.38
HcTHThalamus0.35
0.51
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024627 20 1457 1476 DGHVILQLNSIPSSDFLCVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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