Annotation Detail for TTK
Basic Information Top
| Gene Symbol: | TTK ( CT96,ESK,FLJ38280,MPS1,MPS1L1,PYT ) |
|---|---|
| Gene Full Name: | TTK protein kinase |
| Band: | 6q14.1 |
| Quick Links | Entrez ID:7272; OMIM: 604092; Uniprot ID:TTK_HUMAN; ENSEMBL ID: ENSG00000112742; HGNC ID: 12401 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.169840
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 4 / 62319 | 64 |  |
| fetus | 18 / 564012 | 31 | |
| neonate | 1 / 31097 | 32 | |
| infant | 7 / 23620 | 296 |  |
| juvenile | 4 / 55556 | 71 | |
| adult | 39 / 1939121 | 20 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 5 / 114246 | 43 | |
| esophageal tumor | 2 / 17290 | 115 | |
| gastrointestinal tumor | 2 / 119369 | 16 | |
| germ cell tumor | 22 / 263845 | 83 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 1 / 136302 | 7 |  |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 6 / 95842 | 62 | |
| liver tumor | 5 / 96359 | 51 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 1 / 71755 | 13 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 89 / 3360307 | 26 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 9 / 125680 | 71 | |
| prostate cancer | 2 / 102680 | 19 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 4 / 125191 | 31 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 0 / 29757 | 0 | |
| blood | 7 / 123478 | 56 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 4 / 48801 | 81 | |
| brain | 21 / 1100989 | 19 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 12 / 215722 | 55 | |
| esophagus | 2 / 20209 | 98 | |
| eye | 1 / 211054 | 4 | |
| heart | 1 / 89626 | 11 | |
| intestine | 8 / 234472 | 34 | |
| kidney | 4 / 211777 | 18 | |
| larynx | 0 / 24145 | 0 | |
| liver | 6 / 207743 | 28 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 7 / 91610 | 76 | |
| mammary gland | 6 / 153271 | 39 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 6 / 280825 | 21 | |
| prostate | 4 / 189345 | 21 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 3 / 210574 | 14 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 1 / 96619 | 10 | |
| testis | 74 / 330442 | 223 | |
| thymus | 25 / 81131 | 308 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 6 / 232878 | 25 | |
| vascular | 3 / 51780 | 57 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204822_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 110.45 | |
| Adipocyte | 4.85 | |
| AdrenalCortex | 5.5 | |
| Adrenalgland | 4.25 | |
| Amygdala | 5.1 | |
| Appendix | 5.15 | |
| AtrioventricularNode | 4.1 | |
| BDCA4+_DentriticCells | 5.45 | |
| Bonemarrow | 5.15 | |
| BronchialEpithelialCells | 5 | |
| CD105+_Endothelial | 206.2 | |
| CD14+_Monocytes | 5.15 | |
| CD19+_BCells(neg._sel.) | 5.05 | |
| CD33+_Myeloid | 13.5 | |
| CD34+ | 133.65 | |
| CD4+_Tcells | 5.2 | |
| CD56+_NKCells | 5.75 | |
| CD71+_EarlyErythroid | 161.7 | |
| CD8+_Tcells | 4.65 | |
| CardiacMyocytes | 12.6 | |
| Caudatenucleus | 4.45 | |
| Cerebellum | 4 | |
| CerebellumPeduncles | 5.75 | |
| CiliaryGanglion | 3.75 | |
| CingulateCortex | 5.1 | |
| Colorectaladenocarcinoma | 15.15 | |
| DorsalRootGanglion | 3.95 | |
| FetalThyroid | 4.8 | |
| Fetalbrain | 4.75 | |
| Fetalliver | 23.05 | |
| Fetallung | 4 | |
| GlobusPallidus | 3.75 | |
| Heart | 6.8 | |
| Hypothalamus | 5.3 | |
| Kidney | 4.2 | |
| Leukemia_chronicMyelogenousK-562 | 48.75 | |
| Leukemia_promyelocytic-HL-60 | 64.2 | |
| Leukemialymphoblastic(MOLT-4) | 58.75 | |
| Liver | 6.85 | |
| Lung | 5.4 | |
| Lymphnode | 4.1 | |
| Lymphoma_burkitts(Daudi) | 38.7 | |
| Lymphoma_burkitts(Raji) | 7.35 | |
| MedullaOblongata | 4.45 | |
| OccipitalLobe | 4.35 | |
| OlfactoryBulb | 3.85 | |
| Ovary | 3.4 | |
| Pancreas | 4 | |
| PancreaticIslet | 5.25 | |
| ParietalLobe | 5.35 | |
| Pituitary | 5.75 | |
| Placenta | 4.9 | |
| Pons | 4.75 | |
| PrefrontalCortex | 5.95 | |
| Prostate | 5.65 | |
| Salivarygland | 4 | |
| SkeletalMuscle | 6.15 | |
| Skin | 4.05 | |
| SmoothMuscle | 5.55 | |
| Spinalcord | 5.25 | |
| SubthalamicNucleus | 4.55 | |
| SuperiorCervicalGanglion | 6.05 | |
| TemporalLobe | 4.55 | |
| Testis | 14.7 | |
| TestisGermCell | 65.4 | |
| TestisIntersitial | 61.8 | |
| TestisLeydigCell | 12.25 | |
| TestisSeminiferousTubule | 28.45 | |
| Thalamus | 5.1 | |
| Thymus | 9.2 | |
| Thyroid | 6.05 | |
| Tongue | 5 | |
| Tonsil | 5 | |
| Trachea | 4.1 | |
| TrigeminalGanglion | 5.4 | |
| Uterus | 3.9 | |
| UterusCorpus | 4.55 | |
| WholeBlood | 5.3 | |
| Wholebrain | 4 | |
| colon | 5.2 | |
| pineal_day | 6.04 | |
| pineal_night | 5.92 | |
| retina | 5.9 | |
| small_intestine | 4.8 | |
- Probe name: CUST_13414_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.72 ± 1.19 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.1 ± 0.5 | |
| Basal Part of Pons | 1.87 ± 0.56 | |
| Cerebellar Cortex | 2.36 ± 0.75 | |
| Cerebellar Nuclei | 2.85 ± 0.84 | |
| Claustrum | 3.03 ± 1.01 | |
| Epithalamus | 1.64 ± 0.74 | |
| Frontal Lobe | 1.92 ± 0.77 | |
| Globus Pallidus | 2.56 ± 0.44 | |
| Hypothalamus | 2.14 ± 0.68 | |
| Insula | 1.74 ± 0.39 | |
| Limbic Lobe | 2.19 ± 0.68 | |
| Mesencephalon | 2.26 ± 0.81 | |
| Myelencephalon | 2.1 ± 0.71 | |
| Occipital Lobe | 2.16 ± 0.75 | |
| Parietal Lobe | 2.21 ± 0.92 | |
| Pontine Tegmentum | 2.26 ± 0.92 | |
| Striatum | 2.13 ± 0.79 | |
| Subthalamus | 2.23 ± 0.76 | |
| Temporal Lobe | 2.14 ± 0.8 | |
| Thalamus | 2.03 ± 0.71 | |
| White Matter | 2.05 ± 0.16 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Ttk | CB | Cerebellum | 1.69 | |
| 2.19 | | |||
| Ttk | CTX | Cerebral cortex | 1.4 | |
| 1.63 | | |||
| Ttk | HIP | Hippocampal region | 0.85 | |
| 1.46 | | |||
| Ttk | HPF | Hippocampal formation | 0.75 | |
| 1.06 | | |||
| Ttk | HY | Hypothalamus | 0.32 | |
| 0.43 | | |||
| Ttk | LSX | Lateral septal complex | 1.55 | |
| 1.76 | | |||
| Ttk | MB | Midbrain | 1.01 | |
| 1.36 | | |||
| Ttk | MY | Medulla | 3.1 | |
| 4.14 | | |||
| Ttk | OLF | Olfactory bulb | 1.63 | |
| 1.55 | | |||
| Ttk | P | Pons | 1.41 | |
| 2.04 | | |||
| Ttk | PAL | Pallidum | 0.68 | |
| 0.75 | | |||
| Ttk | RHP | Retrohippocampal region | 0.63 | |
| 0.62 | | |||
| Ttk | sAMY | Striatum-like amygdalar nuclei | 0.75 | |
| 2.09 | | |||
| Ttk | STR | Striatum | 0.92 | |
| 1.08 | | |||
| Ttk | STRd | Striatum dorsal region | 0.68 | |
| 0.87 | | |||
| Ttk | STRv | Striatum ventral region | 1.58 | |
| 1.12 | | |||
| Ttk | TH | Thalamus | 0.45 | |
| 0.44 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00004957 | 19 | 744 | 762 | LHAIIDPNHEIEFPDIPEK | Peptide Atlas |