AutismKB 2.0

Annotation Detail for TUB


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Basic Information Top
Gene Symbol:TUB ( rd5 )
Gene Full Name: tubby homolog (mouse)
Band: 11p15.4
Quick LinksEntrez ID:7275; OMIM: 601197; Uniprot ID:TUB_HUMAN; ENSEMBL ID: ENSG00000166402; HGNC ID: 12406
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus14 / 56401224
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult27 / 193912113
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult21 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal60 / 336030717
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal43 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye12 / 21105456
heart0 / 896260 
intestine1 / 2344724
kidney6 / 21177728
larynx1 / 2414541
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney5 / 21177723
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin28 / 210574132
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210737_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.2
Adipocyte44.8
AdrenalCortex55.25
Adrenalgland41.25
Amygdala46.7
Appendix45.6
AtrioventricularNode35.65
BDCA4+_DentriticCells42.65
Bonemarrow46.5
BronchialEpithelialCells46.95
CD105+_Endothelial44.4
CD14+_Monocytes48.35
CD19+_BCells(neg._sel.)47.4
CD33+_Myeloid56.65
CD34+54.25
CD4+_Tcells45.05
CD56+_NKCells50.5
CD71+_EarlyErythroid42.1
CD8+_Tcells40.2
CardiacMyocytes60.5
Caudatenucleus40.9
Cerebellum56.45
CerebellumPeduncles51.4
CiliaryGanglion32.85
CingulateCortex46.75
Colorectaladenocarcinoma45.65
DorsalRootGanglion35.4
FetalThyroid49.65
Fetalbrain46.05
Fetalliver39.45
Fetallung37.15
GlobusPallidus33.55
Heart78.25
Hypothalamus45.75
Kidney40.85
Leukemia_chronicMyelogenousK-56242.2
Leukemia_promyelocytic-HL-6040.1
Leukemialymphoblastic(MOLT-4)37.2
Liver71.7
Lung49.9
Lymphnode39.4
Lymphoma_burkitts(Daudi)58.55
Lymphoma_burkitts(Raji)64.9
MedullaOblongata41.15
OccipitalLobe40.3
OlfactoryBulb35.6
Ovary38.95
Pancreas36.75
PancreaticIslet48.4
ParietalLobe49.7
Pituitary80.3
Placenta49.45
Pons44.2
PrefrontalCortex53.15
Prostate52.3
Salivarygland36.45
SkeletalMuscle54.5
Skin36.25
SmoothMuscle51.4
Spinalcord48.15
SubthalamicNucleus41.65
SuperiorCervicalGanglion52.35
TemporalLobe41.35
Testis39.15
TestisGermCell37.1
TestisIntersitial38.3
TestisLeydigCell47.75
TestisSeminiferousTubule56.7
Thalamus46.1
Thymus35.5
Thyroid56.1
Tongue49.3
Tonsil44.45
Trachea38
TrigeminalGanglion46.05
Uterus36.65
UterusCorpus42.1
WholeBlood49.75
Wholebrain37.65
colon44.55
pineal_day49.88
pineal_night44.66
retina53.6
small_intestine42.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P53110
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.9 ± 0.77
Basal Forebrain4.36 ± 0.25
Basal Part of Pons4.38 ± 0.34
Cerebellar Cortex4.33 ± 0.56
Cerebellar Nuclei4.44 ± 0.5
Claustrum5.15 ± 0.86
Epithalamus4.2 ± 0.66
Frontal Lobe4.36 ± 0.62
Globus Pallidus4.89 ± 0.39
Hypothalamus4.26 ± 0.48
Insula4.29 ± 0.54
Limbic Lobe4.77 ± 0.61
Mesencephalon4.73 ± 0.66
Myelencephalon4.57 ± 0.58
Occipital Lobe4.68 ± 0.52
Parietal Lobe4.64 ± 0.55
Pontine Tegmentum4.49 ± 0.52
Striatum4.54 ± 0.52
Subthalamus4.4 ± 0.16
Temporal Lobe4.49 ± 0.52
Thalamus4.45 ± 0.57
White Matter4.91 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TubCBCerebellum40.38
96.86
TubCTXCerebral cortex100
100
TubHIPHippocampal region100
100
TubHPFHippocampal formation100
100
TubHYHypothalamus100
100
TubLSXLateral septal complex100
100
TubMBMidbrain100
100
TubMYMedulla75.69
88.31
TubOLFOlfactory bulb100
100
TubPPons75.79
82.47
TubPALPallidum100
100
TubRHPRetrohippocampal region100
100
TubsAMYStriatum-like amygdalar nuclei100
100
TubSTRStriatum100
87.67
TubSTRdStriatum dorsal region85.28
69.88
TubSTRvStriatum ventral region100
100
TubTHThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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