Annotation Detail for D2HGDH
Basic Information Top
| Gene Symbol: | D2HGDH ( D2HGD,FLJ42195,MGC25181 ) |
|---|---|
| Gene Full Name: | D-2-hydroxyglutarate dehydrogenase |
| Band: | 2q37.3 |
| Quick Links | Entrez ID:728294; OMIM: 609186; Uniprot ID:D2HDH_HUMAN; ENSEMBL ID: ENSG00000180902; HGNC ID: 28358 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.516813
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 3 / 62319 | 48 | |
| fetus | 13 / 564012 | 23 | |
| neonate | 2 / 31097 | 64 |  |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 41 / 1939121 | 21 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 2 / 94178 | 21 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 1 / 114246 | 8 |  |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 | |
| germ cell tumor | 4 / 263845 | 15 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 4 / 103127 | 38 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 93 / 3360307 | 27 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 2 / 104616 | 19 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 0 / 29757 | 0 | |
| blood | 2 / 123478 | 16 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 27 / 1100989 | 24 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 6 / 215722 | 27 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 5 / 211054 | 23 | |
| heart | 1 / 89626 | 11 | |
| intestine | 6 / 234472 | 25 | |
| kidney | 11 / 211777 | 51 | |
| larynx | 1 / 24145 | 41 | |
| liver | 0 / 207743 | 0 | |
| lung | 6 / 336974 | 17 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 5 / 15768 | 317 |  |
| ovary | 1 / 102051 | 9 | |
| pancreas | 3 / 214812 | 13 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 12 / 280825 | 42 | |
| prostate | 10 / 189345 | 52 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 5 / 210574 | 23 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 0 / 96619 | 0 | |
| testis | 4 / 330442 | 12 | |
| thymus | 4 / 81131 | 49 | |
| thyroid | 4 / 47473 | 84 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 7 / 232878 | 30 | |
| vascular | 0 / 51780 | 0 |
Microarray in - Probe name: CUST_2727_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.81 ± 0.66 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.6 ± 0.63 | |
| Basal Part of Pons | 3.66 ± 0.43 | |
| Cerebellar Cortex | 3.84 ± 0.45 | |
| Cerebellar Nuclei | 3.65 ± 0.44 | |
| Claustrum | 3.78 ± 0.71 | |
| Epithalamus | 3.94 ± 0.5 | |
| Frontal Lobe | 3.78 ± 0.46 | |
| Globus Pallidus | 4.1 ± 0.58 | |
| Hypothalamus | 3.31 ± 0.38 | |
| Insula | 3.71 ± 0.38 | |
| Limbic Lobe | 3.84 ± 0.55 | |
| Mesencephalon | 3.66 ± 0.55 | |
| Myelencephalon | 3.73 ± 0.55 | |
| Occipital Lobe | 3.78 ± 0.5 | |
| Parietal Lobe | 3.68 ± 0.57 | |
| Pontine Tegmentum | 3.71 ± 0.57 | |
| Striatum | 3.66 ± 0.67 | |
| Subthalamus | 3.85 ± 0.53 | |
| Temporal Lobe | 3.75 ± 0.54 | |
| Thalamus | 3.76 ± 0.47 | |
| White Matter | 4.58 ± 0.44 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| D2hgdh | CB | Cerebellum | 1.64 | |
| 4.46 | | |||
| D2hgdh | CTX | Cerebral cortex | 0.34 | |
| 0.63 | | |||
| D2hgdh | HIP | Hippocampal region | 1.47 | |
| 1.77 | | |||
| D2hgdh | HPF | Hippocampal formation | 1.09 | |
| 1.46 | | |||
| D2hgdh | HY | Hypothalamus | 1.13 | |
| 1.42 | | |||
| D2hgdh | LSX | Lateral septal complex | 0.34 | |
| 0.51 | | |||
| D2hgdh | MB | Midbrain | 0.49 | |
| 1.39 | | |||
| D2hgdh | MY | Medulla | 0.38 | |
| 0.71 | | |||
| D2hgdh | OLF | Olfactory bulb | 0.96 | |
| 1.53 | | |||
| D2hgdh | P | Pons | 0.72 | |
| 1.95 | | |||
| D2hgdh | PAL | Pallidum | 1.91 | |
| 1.98 | | |||
| D2hgdh | RHP | Retrohippocampal region | 0.48 | |
| 1.09 | | |||
| D2hgdh | sAMY | Striatum-like amygdalar nuclei | 0.27 | |
| 0.8 | | |||
| D2hgdh | STR | Striatum | 0.44 | |
| 0.66 | | |||
| D2hgdh | STRd | Striatum dorsal region | 0.16 | |
| 0.28 | | |||
| D2hgdh | STRv | Striatum ventral region | 1.35 | |
| 1.67 | | |||
| D2hgdh | TH | Thalamus | 0.3 | |
| 0.5 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00082136 | 17 | 196 | 212 | GSCHIGGNVATNAGGLR | Peptide Atlas |