AutismKB 2.0

Annotation Detail for DHRS4L1


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Basic Information Top
Gene Symbol:DHRS4L1 ( SDR25C4 )
Gene Full Name: dehydrogenase/reductase (SDR family) member 4 like 1
Band: 14q11.2
Quick LinksEntrez ID:728635; OMIM: NA; Uniprot ID:DR4L1_HUMAN; ENSEMBL ID: ; HGNC ID: 19732
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal9 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218021_at
Cell line Expression level Expression bar
721_B_lymphoblasts281.55
Adipocyte97.55
AdrenalCortex60.5
Adrenalgland52.55
Amygdala42.55
Appendix77.45
AtrioventricularNode30.95
BDCA4+_DentriticCells78.9
Bonemarrow53.95
BronchialEpithelialCells109.1
CD105+_Endothelial59.15
CD14+_Monocytes182.55
CD19+_BCells(neg._sel.)38.95
CD33+_Myeloid189.25
CD34+57.5
CD4+_Tcells56.5
CD56+_NKCells58.65
CD71+_EarlyErythroid37.4
CD8+_Tcells60.9
CardiacMyocytes45
Caudatenucleus47.7
Cerebellum38.6
CerebellumPeduncles44
CiliaryGanglion28.1
CingulateCortex50.5
Colorectaladenocarcinoma63.7
DorsalRootGanglion48.75
FetalThyroid60
Fetalbrain38.2
Fetalliver72.55
Fetallung63.35
GlobusPallidus28.2
Heart163.35
Hypothalamus73.1
Kidney368.4
Leukemia_chronicMyelogenousK-56227.2
Leukemia_promyelocytic-HL-6025.55
Leukemialymphoblastic(MOLT-4)41
Liver287.7
Lung193.15
Lymphnode49.9
Lymphoma_burkitts(Daudi)35.9
Lymphoma_burkitts(Raji)72.65
MedullaOblongata41.1
OccipitalLobe34.1
OlfactoryBulb74.6
Ovary33.05
Pancreas55.75
PancreaticIslet68.65
ParietalLobe42.4
Pituitary57.4
Placenta39.85
Pons55.2
PrefrontalCortex44.05
Prostate104.4
Salivarygland34.4
SkeletalMuscle145.65
Skin67.75
SmoothMuscle63.9
Spinalcord50.6
SubthalamicNucleus39.65
SuperiorCervicalGanglion62.55
TemporalLobe38.7
Testis112.35
TestisGermCell62
TestisIntersitial88.35
TestisLeydigCell59.1
TestisSeminiferousTubule72.8
Thalamus43.2
Thymus65.4
Thyroid183.3
Tongue55.05
Tonsil54.05
Trachea45.75
TrigeminalGanglion75.35
Uterus49.45
UterusCorpus35.1
WholeBlood60.95
Wholebrain37.25
colon158.45
pineal_day43.28
pineal_night39.22
retina67.45
small_intestine196.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P903378
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.57 ± 0.77
Basal Forebrain2.91 ± 0.65
Basal Part of Pons3.3 ± 0.38
Cerebellar Cortex2.89 ± 0.46
Cerebellar Nuclei3.22 ± 0.67
Claustrum3.18 ± 0.66
Epithalamus3.17 ± 0.41
Frontal Lobe3.16 ± 0.58
Globus Pallidus3.67 ± 0.34
Hypothalamus2.95 ± 0.56
Insula2.73 ± 0.83
Limbic Lobe3.21 ± 0.56
Mesencephalon3.23 ± 0.64
Myelencephalon3.25 ± 0.59
Occipital Lobe3.28 ± 0.64
Parietal Lobe3.28 ± 0.62
Pontine Tegmentum3.24 ± 0.71
Striatum3.92 ± 0.44
Subthalamus3.36 ± 0.81
Temporal Lobe3.21 ± 0.57
Thalamus3.37 ± 0.49
White Matter3.17 ± 0.36
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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