AutismKB 2.0

Annotation Detail for TXK


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Basic Information Top
Gene Symbol:TXK ( BTKL,MGC22473,PSCTK5,PTK4,RLK,TKL )
Gene Full Name: TXK tyrosine kinase
Band: 4p12
Quick LinksEntrez ID:7294; OMIM: 600058; Uniprot ID:TXK_HUMAN; ENSEMBL ID: ENSG00000074966; HGNC ID: 12434
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult31 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal36 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow1 / 4880120
brain0 / 11009890 
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver3 / 20774314
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta24 / 28082585
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach2 / 9661920
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206828_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.25
Adipocyte4.35
AdrenalCortex4.9
Adrenalgland3.8
Amygdala4.6
Appendix4.6
AtrioventricularNode3.6
BDCA4+_DentriticCells4.65
Bonemarrow4.55
BronchialEpithelialCells4.35
CD105+_Endothelial4.55
CD14+_Monocytes4.65
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid5.5
CD34+5.6
CD4+_Tcells173.2
CD56+_NKCells228
CD71+_EarlyErythroid4.2
CD8+_Tcells187.45
CardiacMyocytes6.1
Caudatenucleus4
Cerebellum3.65
CerebellumPeduncles5.15
CiliaryGanglion3.25
CingulateCortex4.6
Colorectaladenocarcinoma4.45
DorsalRootGanglion3.5
FetalThyroid4.3
Fetalbrain4.35
Fetalliver3.9
Fetallung3.55
GlobusPallidus3.4
Heart6.1
Hypothalamus4.8
Kidney3.7
Leukemia_chronicMyelogenousK-5624.05
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.55
Liver6.75
Lung4.85
Lymphnode3.85
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.45
MedullaOblongata4.05
OccipitalLobe4
OlfactoryBulb3.5
Ovary3.05
Pancreas3.65
PancreaticIslet4.8
ParietalLobe4.8
Pituitary5.2
Placenta9.6
Pons4.3
PrefrontalCortex5.45
Prostate5.15
Salivarygland3.6
SkeletalMuscle5.45
Skin3.5
SmoothMuscle5
Spinalcord4.75
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.25
TemporalLobe4.25
Testis3.8
TestisGermCell3.65
TestisIntersitial3.75
TestisLeydigCell4.45
TestisSeminiferousTubule3.85
Thalamus4.55
Thymus3.45
Thyroid5.55
Tongue4.75
Tonsil4.35
Trachea3.75
TrigeminalGanglion4.6
Uterus3.6
UterusCorpus4.05
WholeBlood4.85
Wholebrain3.65
colon4.5
pineal_day5.48
pineal_night5.34
retina5.45
small_intestine4.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P921122
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.07 ± 1
Basal Forebrain1.49 ± 0.21
Basal Part of Pons1.32 ± 0.45
Cerebellar Cortex1.44 ± 0.83
Cerebellar Nuclei1.8 ± 0.76
Claustrum2.47 ± 0.95
Epithalamus1.56 ± 0.78
Frontal Lobe1.35 ± 0.67
Globus Pallidus2.02 ± 0.3
Hypothalamus1.62 ± 0.74
Insula1.32 ± 0.47
Limbic Lobe1.53 ± 0.61
Mesencephalon1.76 ± 0.81
Myelencephalon1.57 ± 0.69
Occipital Lobe1.73 ± 0.69
Parietal Lobe1.6 ± 0.82
Pontine Tegmentum1.6 ± 0.71
Striatum1.71 ± 0.47
Subthalamus1.71 ± 0.53
Temporal Lobe1.5 ± 0.76
Thalamus1.49 ± 0.64
White Matter1.87 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TxkCBCerebellum5.58
5.82
TxkCTXCerebral cortex8.55
6.58
TxkHIPHippocampal region6.68
8.16
TxkHPFHippocampal formation8.06
8.04
TxkHYHypothalamus2.01
1.84
TxkLSXLateral septal complex0.27
0.31
TxkMBMidbrain2.6
2.42
TxkMYMedulla3.75
4.01
TxkOLFOlfactory bulb18.44
15.9
TxkPPons7.19
6.84
TxkPALPallidum4.08
3.73
TxkRHPRetrohippocampal region11.39
8.48
TxksAMYStriatum-like amygdalar nuclei4.18
3.14
TxkSTRStriatum3.37
2.41
TxkSTRdStriatum dorsal region3.64
2.6
TxkSTRvStriatum ventral region3.44
2.33
TxkTHThalamus8.78
8.17
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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