AutismKB 2.0

Annotation Detail for TYK2


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Basic Information Top
Gene Symbol:TYK2 ( JTK1 )
Gene Full Name: tyrosine kinase 2
Band: 19p13.2
Quick LinksEntrez ID:7297; OMIM: 176941; Uniprot ID:TYK2_HUMAN; ENSEMBL ID: ENSG00000105397; HGNC ID: 12440
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus56 / 56401299
neonate15 / 31097482
infant0 / 236200 
juvenile2 / 5555635
adult152 / 193912178
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor4 / 34366116
chondrosarcoma10 / 82823120
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor23 / 26384587
glioma19 / 106883177
head and neck tumor19 / 136302139
kidney tumor8 / 68959116
leukemia17 / 95842177
liver tumor6 / 9635962
lung tumor13 / 103127126
lymphoma13 / 71755181
non-neoplasia5 / 9725051
normal291 / 336030786
ovarian tumor12 / 76682156
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer11 / 102680107
retinoblastoma0 / 463560 
skin tumor8 / 12494964
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites6 / 40015149
bladder2 / 2975767
blood17 / 123478137
bone9 / 71655125
bone marrow5 / 48801102
brain161 / 1100989146
cervix4 / 4817183
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye11 / 21105452
heart5 / 8962655
intestine12 / 23447251
kidney15 / 21177770
larynx1 / 2414541
liver10 / 20774348
lung27 / 33697480
lymph8 / 44270180
lymph node10 / 91610109
mammary gland5 / 15327132
mouth16 / 67052238
muscle13 / 107715120
nerve2 / 15768126
ovary13 / 102051127
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta17 / 28082560
prostate16 / 18934584
salivary gland0 / 201550 
skin9 / 21057442
spleen4 / 5395274
stomach1 / 9661910
testis24 / 33044272
thymus25 / 81131308
thyroid6 / 47473126
tonsil1 / 1699958
trachea18 / 52413343
umbilical cord17 / 136801242
uterus28 / 232878120
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205546_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts268.9
Adipocyte33.4
AdrenalCortex42.6
Adrenalgland38.5
Amygdala42.35
Appendix23.85
AtrioventricularNode18.95
BDCA4+_DentriticCells284.75
Bonemarrow37.05
BronchialEpithelialCells28.25
CD105+_Endothelial79.35
CD14+_Monocytes350.65
CD19+_BCells(neg._sel.)117.7
CD33+_Myeloid370.8
CD34+164.7
CD4+_Tcells213.65
CD56+_NKCells164
CD71+_EarlyErythroid33.6
CD8+_Tcells256.75
CardiacMyocytes30.8
Caudatenucleus31.2
Cerebellum28
CerebellumPeduncles35.9
CiliaryGanglion17.1
CingulateCortex36.2
Colorectaladenocarcinoma48.25
DorsalRootGanglion17.2
FetalThyroid34.95
Fetalbrain33.1
Fetalliver24.7
Fetallung32.45
GlobusPallidus15.25
Heart62.9
Hypothalamus47.2
Kidney31.55
Leukemia_chronicMyelogenousK-56265.95
Leukemia_promyelocytic-HL-6042.1
Leukemialymphoblastic(MOLT-4)58.15
Liver61.55
Lung56.75
Lymphnode75.45
Lymphoma_burkitts(Daudi)69.55
Lymphoma_burkitts(Raji)134.1
MedullaOblongata30.5
OccipitalLobe26.6
OlfactoryBulb36.35
Ovary18.45
Pancreas31.25
PancreaticIslet38.75
ParietalLobe27.4
Pituitary41.5
Placenta31.35
Pons19.2
PrefrontalCortex53.65
Prostate42.75
Salivarygland29.4
SkeletalMuscle39.45
Skin18.35
SmoothMuscle34.6
Spinalcord39.5
SubthalamicNucleus27.5
SuperiorCervicalGanglion32.3
TemporalLobe31.5
Testis22.75
TestisGermCell23.1
TestisIntersitial11.6
TestisLeydigCell23.75
TestisSeminiferousTubule19.7
Thalamus36.05
Thymus93.4
Thyroid50.65
Tongue34.15
Tonsil80.85
Trachea29.65
TrigeminalGanglion22.55
Uterus25.75
UterusCorpus30.7
WholeBlood182.2
Wholebrain31.55
colon28.05
pineal_day36.9
pineal_night42.36
retina47
small_intestine29.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P141917
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.07 ± 0.93
Basal Forebrain1.41 ± 0.34
Basal Part of Pons1.31 ± 0.39
Cerebellar Cortex2.22 ± 0.65
Cerebellar Nuclei1.93 ± 0.69
Claustrum2.24 ± 0.79
Epithalamus1.59 ± 0.7
Frontal Lobe1.78 ± 0.73
Globus Pallidus1.48 ± 0.68
Hypothalamus1.73 ± 0.65
Insula1.67 ± 0.67
Limbic Lobe1.69 ± 0.67
Mesencephalon1.91 ± 0.89
Myelencephalon1.85 ± 0.66
Occipital Lobe1.66 ± 0.7
Parietal Lobe1.76 ± 0.7
Pontine Tegmentum1.82 ± 0.67
Striatum1.55 ± 0.67
Subthalamus1.73 ± 0.7
Temporal Lobe1.89 ± 0.66
Thalamus1.84 ± 0.54
White Matter2.01 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tyk2CBCerebellum3.16
3.61
Tyk2CTXCerebral cortex7.89
5.45
Tyk2HIPHippocampal region12.73
14.28
Tyk2HPFHippocampal formation10.29
10.21
Tyk2HYHypothalamus1.8
1.54
Tyk2LSXLateral septal complex1.63
1.26
Tyk2MBMidbrain4.23
4.17
Tyk2MYMedulla8.16
7.55
Tyk2OLFOlfactory bulb12.68
8.7
Tyk2PPons3.99
3.38
Tyk2PALPallidum2.61
1.93
Tyk2RHPRetrohippocampal region6.07
4.55
Tyk2sAMYStriatum-like amygdalar nuclei1.44
0.95
Tyk2STRStriatum2.1
1.46
Tyk2STRdStriatum dorsal region0.89
0.62
Tyk2STRvStriatum ventral region6.61
4.22
Tyk2THThalamus4.33
3.52
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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