AutismKB 2.0

Annotation Detail for TYRO3


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Basic Information Top
Gene Symbol:TYRO3 ( BYK,Dtk,FLJ16467,RSE,Sky,Tif )
Gene Full Name: TYRO3 protein tyrosine kinase
Band: 15q15.1
Quick LinksEntrez ID:7301; OMIM: 600341; Uniprot ID:TYRO3_HUMAN; ENSEMBL ID: ENSG00000092445; HGNC ID: 12446
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus17 / 56401230
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor3 / 3436687
chondrosarcoma7 / 8282384
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor16 / 26384560
glioma15 / 106883140
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal81 / 336030724
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain61 / 110098955
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye6 / 21105428
heart4 / 8962644
intestine3 / 23447212
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve3 / 15768190
ovary9 / 10205188
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta14 / 28082549
prostate2 / 18934510
salivary gland0 / 201550 
skin11 / 21057452
spleen0 / 539520 
stomach1 / 9661910
testis11 / 33044233
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211432_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts20.1
Adipocyte40.95
AdrenalCortex58.7
Adrenalgland42.2
Amygdala160.8
Appendix34.9
AtrioventricularNode22.9
BDCA4+_DentriticCells19.8
Bonemarrow30.15
BronchialEpithelialCells22.1
CD105+_Endothelial23.35
CD14+_Monocytes18.6
CD19+_BCells(neg._sel.)22.8
CD33+_Myeloid27.05
CD34+23.3
CD4+_Tcells17
CD56+_NKCells20.5
CD71+_EarlyErythroid21.55
CD8+_Tcells17.3
CardiacMyocytes26.05
Caudatenucleus150.3
Cerebellum250.15
CerebellumPeduncles229.05
CiliaryGanglion32.8
CingulateCortex279.6
Colorectaladenocarcinoma30.35
DorsalRootGanglion37
FetalThyroid30.1
Fetalbrain49.7
Fetalliver23.4
Fetallung21.3
GlobusPallidus113.4
Heart51.35
Hypothalamus118.9
Kidney33.45
Leukemia_chronicMyelogenousK-56243.25
Leukemia_promyelocytic-HL-6017.5
Leukemialymphoblastic(MOLT-4)20.9
Liver28.75
Lung23
Lymphnode18.25
Lymphoma_burkitts(Daudi)28.7
Lymphoma_burkitts(Raji)29.9
MedullaOblongata194.7
OccipitalLobe173.95
OlfactoryBulb72.7
Ovary21.35
Pancreas17.8
PancreaticIslet26.95
ParietalLobe173.35
Pituitary35.5
Placenta25.4
Pons167.85
PrefrontalCortex339.9
Prostate20.2
Salivarygland37.7
SkeletalMuscle35.5
Skin35.05
SmoothMuscle23.7
Spinalcord147
SubthalamicNucleus172.95
SuperiorCervicalGanglion82.35
TemporalLobe164.25
Testis97.4
TestisGermCell89.55
TestisIntersitial37.5
TestisLeydigCell36.65
TestisSeminiferousTubule56.85
Thalamus129.25
Thymus15.2
Thyroid20.2
Tongue31.15
Tonsil30.15
Trachea23.25
TrigeminalGanglion44.75
Uterus18.8
UterusCorpus35.15
WholeBlood20.8
Wholebrain375.9
colon20.25
pineal_day47.46
pineal_night55.3
retina91.875
small_intestine22.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10266_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.96 ± 0.75
Basal Forebrain5.82 ± 0.42
Basal Part of Pons5.58 ± 0.65
Cerebellar Cortex5.99 ± 0.25
Cerebellar Nuclei5.63 ± 0.5
Claustrum6.58 ± 0.43
Epithalamus5.43 ± 0.13
Frontal Lobe5.76 ± 0.43
Globus Pallidus5.39 ± 0.29
Hypothalamus5.17 ± 0.71
Insula5.85 ± 0.34
Limbic Lobe5.82 ± 0.63
Mesencephalon5.6 ± 0.63
Myelencephalon5.66 ± 0.68
Occipital Lobe5.5 ± 0.67
Parietal Lobe5.66 ± 0.6
Pontine Tegmentum5.79 ± 0.66
Striatum4.45 ± 0.68
Subthalamus5.08 ± 0.39
Temporal Lobe6.02 ± 0.43
Thalamus5.32 ± 0.62
White Matter6.84 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tyro3CBCerebellum71.73
73.79
Tyro3CTXCerebral cortex100
100
Tyro3HIPHippocampal region53.58
80.95
Tyro3HPFHippocampal formation82.97
100
Tyro3HYHypothalamus30.31
22.95
Tyro3LSXLateral septal complex100
100
Tyro3MBMidbrain38.91
32.12
Tyro3MYMedulla43.96
41.1
Tyro3OLFOlfactory bulb99.66
100
Tyro3PPons39.97
34.53
Tyro3PALPallidum44.33
41.72
Tyro3RHPRetrohippocampal region100
100
Tyro3sAMYStriatum-like amygdalar nuclei42.41
39.08
Tyro3STRStriatum100
100
Tyro3STRdStriatum dorsal region100
100
Tyro3STRvStriatum ventral region100
100
Tyro3THThalamus34.05
25.51
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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