AutismKB 2.0

Annotation Detail for TYROBP


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Basic Information Top
Gene Symbol:TYROBP ( DAP12,KARAP,PLOSL )
Gene Full Name: TYRO protein tyrosine kinase binding protein
Band: 19q13.12
Quick LinksEntrez ID:7305; OMIM: 604142; Uniprot ID:TYOBP_HUMAN; ENSEMBL ID: ENSG00000011600; HGNC ID: 12449
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult106 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma4 / 10688337
head and neck tumor31 / 136302227
kidney tumor3 / 6895943
leukemia8 / 9584283
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal76 / 336030722
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood12 / 12347897
bone3 / 7165541
bone marrow5 / 48801102
brain8 / 11009897
cervix0 / 481710 
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart4 / 8962644
intestine9 / 23447238
kidney12 / 21177756
larynx1 / 2414541
liver2 / 2077439
lung7 / 33697420
lymph0 / 442700 
lymph node1 / 9161010
mammary gland11 / 15327171
mouth27 / 67052402
muscle4 / 10771537
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach0 / 966190 
testis2 / 3304426
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204122_at
Cell line Expression level Expression bar
721_B_lymphoblasts25.55
Adipocyte21.25
AdrenalCortex54.7
Adrenalgland56.7
Amygdala43.35
Appendix26.55
AtrioventricularNode17.35
BDCA4+_DentriticCells4592.8
Bonemarrow945.65
BronchialEpithelialCells12.65
CD105+_Endothelial768.3
CD14+_Monocytes13385.4
CD19+_BCells(neg._sel.)31.95
CD33+_Myeloid12668.2
CD34+393.2
CD4+_Tcells34.55
CD56+_NKCells7096.45
CD71+_EarlyErythroid64.2
CD8+_Tcells56.5
CardiacMyocytes19.35
Caudatenucleus22.25
Cerebellum16.95
CerebellumPeduncles29.9
CiliaryGanglion31.6
CingulateCortex21.15
Colorectaladenocarcinoma14.75
DorsalRootGanglion30.8
FetalThyroid14.55
Fetalbrain20.2
Fetalliver20.8
Fetallung198.5
GlobusPallidus16.55
Heart950.55
Hypothalamus102.25
Kidney20.85
Leukemia_chronicMyelogenousK-56219.05
Leukemia_promyelocytic-HL-6014.05
Leukemialymphoblastic(MOLT-4)16.5
Liver440.4
Lung3405.55
Lymphnode519.5
Lymphoma_burkitts(Daudi)26.65
Lymphoma_burkitts(Raji)29.3
MedullaOblongata20.6
OccipitalLobe28
OlfactoryBulb167.35
Ovary35
Pancreas17.95
PancreaticIslet36.4
ParietalLobe27.3
Pituitary28.55
Placenta423.75
Pons21.4
PrefrontalCortex30.5
Prostate44.6
Salivarygland27.65
SkeletalMuscle40
Skin17.25
SmoothMuscle23.15
Spinalcord157.65
SubthalamicNucleus19.15
SuperiorCervicalGanglion23.3
TemporalLobe28.65
Testis17.75
TestisGermCell17.55
TestisIntersitial18.55
TestisLeydigCell22.05
TestisSeminiferousTubule17.95
Thalamus54.45
Thymus159.75
Thyroid42.8
Tongue25.3
Tonsil92.5
Trachea19.9
TrigeminalGanglion28.1
Uterus51.35
UterusCorpus88
WholeBlood12348.15
Wholebrain64.2
colon31.65
pineal_day54.02
pineal_night40.86
retina278.225
small_intestine280.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15798_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.88 ± 0.44
Basal Forebrain6.17 ± 0.32
Basal Part of Pons6.88 ± 0.48
Cerebellar Cortex5.68 ± 0.32
Cerebellar Nuclei7.53 ± 0.31
Claustrum5.79 ± 0.67
Epithalamus7.27 ± 0.55
Frontal Lobe6.12 ± 0.66
Globus Pallidus7.84 ± 0.5
Hypothalamus6.44 ± 1.18
Insula6.12 ± 0.48
Limbic Lobe5.86 ± 0.61
Mesencephalon6.27 ± 0.7
Myelencephalon6.22 ± 0.71
Occipital Lobe5.63 ± 0.59
Parietal Lobe6.16 ± 0.61
Pontine Tegmentum5.94 ± 0.5
Striatum6.89 ± 0.46
Subthalamus6.82 ± 0.47
Temporal Lobe6.25 ± 0.6
Thalamus6.08 ± 0.41
White Matter7.12 ± 0.77
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TyrobpCBCerebellum6.84
7.49
TyrobpCTXCerebral cortex15.67
12.59
TyrobpHIPHippocampal region12.39
11.91
TyrobpHPFHippocampal formation10.6
9.28
TyrobpHYHypothalamus2.42
1.82
TyrobpLSXLateral septal complex3.86
3.09
TyrobpMBMidbrain1.94
2.37
TyrobpMYMedulla3.52
3.88
TyrobpOLFOlfactory bulb18.56
14.54
TyrobpPPons3.09
3.81
TyrobpPALPallidum4.26
3.59
TyrobpRHPRetrohippocampal region7.49
5.54
TyrobpsAMYStriatum-like amygdalar nuclei3
2.22
TyrobpSTRStriatum6.35
4.68
TyrobpSTRdStriatum dorsal region6.61
5.15
TyrobpSTRvStriatum ventral region8.12
4.92
TyrobpTHThalamus3.35
3.03
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
TYOBP_HUMAN_0 0 0 0 ITETESPYQELQGQR PRIDE
TYOBP_HUMAN_83 15 83 97 ITETESPYQELQGQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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