AutismKB 2.0

Annotation Detail for UBE2D3


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Basic Information Top
Gene Symbol:UBE2D3 ( E2(17)KB3,MGC43926,MGC5416,UBC4/5,UBCH5C )
Gene Full Name: ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
Band: 4q24
Quick LinksEntrez ID:7323; OMIM: 602963; Uniprot ID:UB2D3_HUMAN; ENSEMBL ID: ENSG00000109332; HGNC ID: 12476
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body26 / 70761367
blastocyst20 / 62319320
fetus137 / 564012242
neonate25 / 31097803
infant24 / 236201016
juvenile20 / 55556359
adult413 / 1939121212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma6 / 17475343
breast (mammary gland) tumor30 / 94178318
cervical tumor13 / 34366378
chondrosarcoma6 / 8282372
colorectal tumor25 / 114246218
esophageal tumor7 / 17290404
gastrointestinal tumor31 / 119369259
germ cell tumor88 / 263845333
glioma25 / 106883233
head and neck tumor17 / 136302124
kidney tumor14 / 68959203
leukemia25 / 95842260
liver tumor28 / 96359290
lung tumor9 / 10312787
lymphoma10 / 71755139
non-neoplasia31 / 97250318
normal1081 / 3360307321
ovarian tumor21 / 76682273
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS50 / 125680397
prostate cancer22 / 102680214
retinoblastoma13 / 46356280
skin tumor23 / 124949184
soft tissue/muscle tissue tumor29 / 125191231
uterine tumor20 / 90257221
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland25 / 33197753
ascites11 / 40015274
bladder22 / 29757739
blood49 / 123478396
bone9 / 71655125
bone marrow20 / 48801409
brain440 / 1100989399
cervix20 / 48171415
connective tissue42 / 149255281
ear3 / 16212185
embryonic tissue77 / 215722356
esophagus7 / 20209346
eye39 / 211054184
heart27 / 89626301
intestine73 / 234472311
kidney77 / 211777363
larynx0 / 241450 
liver56 / 207743269
lung76 / 336974225
lymph1 / 4427022
lymph node22 / 91610240
mammary gland35 / 153271228
mouth7 / 67052104
muscle12 / 107715111
nerve3 / 15768190
ovary20 / 102051195
pancreas36 / 214812167
parathyroid9 / 20539438
pharynx6 / 41328145
pituitary gland6 / 16585361
placenta73 / 280825259
prostate55 / 189345290
salivary gland3 / 20155148
skin52 / 210574246
spleen26 / 53952481
stomach27 / 96619279
testis112 / 330442338
thymus69 / 81131850
thyroid7 / 47473147
tonsil2 / 16999117
trachea36 / 52413686
umbilical cord6 / 13680438
uterus91 / 232878390
vascular34 / 51780656
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200667_at
Cell line Expression level Expression bar
721_B_lymphoblasts663.45
Adipocyte181.05
AdrenalCortex233.95
Adrenalgland209.85
Amygdala249.55
Appendix73.45
AtrioventricularNode60.3
BDCA4+_DentriticCells642.1
Bonemarrow153.5
BronchialEpithelialCells589.35
CD105+_Endothelial492.65
CD14+_Monocytes775.55
CD19+_BCells(neg._sel.)895.3
CD33+_Myeloid796.6
CD34+506.5
CD4+_Tcells537.3
CD56+_NKCells967.95
CD71+_EarlyErythroid620.65
CD8+_Tcells503.95
CardiacMyocytes270
Caudatenucleus168.95
Cerebellum58.4
CerebellumPeduncles132.45
CiliaryGanglion51.7
CingulateCortex199.15
Colorectaladenocarcinoma108.15
DorsalRootGanglion57.9
FetalThyroid263.6
Fetalbrain228.75
Fetalliver233
Fetallung293.4
GlobusPallidus74.85
Heart66.9
Hypothalamus376.8
Kidney133.65
Leukemia_chronicMyelogenousK-562142.8
Leukemia_promyelocytic-HL-60215.85
Leukemialymphoblastic(MOLT-4)271.2
Liver176.15
Lung256.7
Lymphnode193.95
Lymphoma_burkitts(Daudi)271.6
Lymphoma_burkitts(Raji)251.05
MedullaOblongata124.95
OccipitalLobe250.5
OlfactoryBulb194
Ovary164.1
Pancreas150.05
PancreaticIslet392.4
ParietalLobe195.8
Pituitary301.05
Placenta345
Pons111.75
PrefrontalCortex304.55
Prostate410.8
Salivarygland157.85
SkeletalMuscle73.9
Skin88.25
SmoothMuscle333.6
Spinalcord197.3
SubthalamicNucleus156.85
SuperiorCervicalGanglion20.55
TemporalLobe117.05
Testis120.4
TestisGermCell209.45
TestisIntersitial66.8
TestisLeydigCell68.4
TestisSeminiferousTubule96.05
Thalamus236.25
Thymus287.85
Thyroid486.9
Tongue110.3
Tonsil205.65
Trachea146.1
TrigeminalGanglion30
Uterus333.65
UterusCorpus83.2
WholeBlood993.85
Wholebrain248.75
colon494
pineal_day378.16
pineal_night354.48
retina255.225
small_intestine454.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P58293
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.86 ± 0.29
Basal Forebrain7.62 ± 0.11
Basal Part of Pons7.86 ± 0.14
Cerebellar Cortex7.77 ± 0.19
Cerebellar Nuclei7.92 ± 0.19
Claustrum7.82 ± 0.43
Epithalamus7.75 ± 0.25
Frontal Lobe7.76 ± 0.25
Globus Pallidus7.51 ± 0.22
Hypothalamus7.84 ± 0.26
Insula7.72 ± 0.14
Limbic Lobe7.7 ± 0.27
Mesencephalon7.63 ± 0.28
Myelencephalon7.68 ± 0.27
Occipital Lobe7.67 ± 0.24
Parietal Lobe7.74 ± 0.2
Pontine Tegmentum7.73 ± 0.24
Striatum7.53 ± 0.29
Subthalamus7.68 ± 0.2
Temporal Lobe7.71 ± 0.25
Thalamus7.7 ± 0.2
White Matter7.94 ± 0.15
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004145 18 73 90 IYHPNINSNGSICLDILR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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