AutismKB 2.0

Annotation Detail for UBE2I


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Basic Information Top
Gene Symbol:UBE2I ( C358B7.1,P18,UBC9 )
Gene Full Name: ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
Band: 16p13.3
Quick LinksEntrez ID:7329; OMIM: 601661; Uniprot ID:UBC9_HUMAN; ENSEMBL ID: ENSG00000103275; HGNC ID: 12485
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst6 / 6231996
fetus59 / 564012104
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult225 / 1939121116
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor3 / 3436687
chondrosarcoma9 / 82823108
colorectal tumor20 / 114246175
esophageal tumor1 / 1729057
gastrointestinal tumor59 / 119369494
germ cell tumor27 / 263845102
glioma16 / 106883149
head and neck tumor4 / 13630229
kidney tumor9 / 68959130
leukemia17 / 95842177
liver tumor4 / 9635941
lung tumor13 / 103127126
lymphoma5 / 7175569
non-neoplasia6 / 9725061
normal339 / 3360307100
ovarian tumor27 / 76682352
pancreatic tumor21 / 104616200
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer12 / 102680116
retinoblastoma1 / 4635621
skin tumor17 / 124949136
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland2 / 3319760
ascites5 / 40015124
bladder2 / 2975767
blood8 / 12347864
bone4 / 7165555
bone marrow4 / 4880181
brain77 / 110098969
cervix4 / 4817183
connective tissue8 / 14925553
ear2 / 16212123
embryonic tissue19 / 21572288
esophagus1 / 2020949
eye14 / 21105466
heart18 / 89626200
intestine45 / 234472191
kidney23 / 211777108
larynx1 / 2414541
liver14 / 20774367
lung46 / 336974136
lymph1 / 4427022
lymph node33 / 91610360
mammary gland11 / 15327171
mouth1 / 6705214
muscle8 / 10771574
nerve2 / 15768126
ovary33 / 102051323
pancreas41 / 214812190
parathyroid6 / 20539292
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta27 / 28082596
prostate22 / 189345116
salivary gland0 / 201550 
skin30 / 210574142
spleen6 / 53952111
stomach54 / 96619558
testis26 / 33044278
thymus3 / 8113136
thyroid26 / 47473547
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord2 / 13680146
uterus21 / 23287890
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213535_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts942.4
Adipocyte164.15
AdrenalCortex107.55
Adrenalgland190.65
Amygdala100.85
Appendix25.3
AtrioventricularNode19.7
BDCA4+_DentriticCells881.6
Bonemarrow240.35
BronchialEpithelialCells556.4
CD105+_Endothelial725.05
CD14+_Monocytes691.25
CD19+_BCells(neg._sel.)1135.25
CD33+_Myeloid961.3
CD34+1272.25
CD4+_Tcells447.15
CD56+_NKCells980.95
CD71+_EarlyErythroid363.2
CD8+_Tcells398.2
CardiacMyocytes272.75
Caudatenucleus39.8
Cerebellum123.95
CerebellumPeduncles144.35
CiliaryGanglion13.1
CingulateCortex97.05
Colorectaladenocarcinoma358.5
DorsalRootGanglion21.2
FetalThyroid126.3
Fetalbrain135.25
Fetalliver94.85
Fetallung172.8
GlobusPallidus31.9
Heart314.4
Hypothalamus101.1
Kidney81.15
Leukemia_chronicMyelogenousK-562281.2
Leukemia_promyelocytic-HL-60279.6
Leukemialymphoblastic(MOLT-4)534.75
Liver140.6
Lung569.5
Lymphnode159.95
Lymphoma_burkitts(Daudi)608.75
Lymphoma_burkitts(Raji)285.8
MedullaOblongata35.4
OccipitalLobe38.55
OlfactoryBulb85.35
Ovary102.15
Pancreas103.85
PancreaticIslet180.6
ParietalLobe47.45
Pituitary178.05
Placenta304.1
Pons44.45
PrefrontalCortex138.75
Prostate417.4
Salivarygland100.85
SkeletalMuscle28.45
Skin23.85
SmoothMuscle344.85
Spinalcord58.55
SubthalamicNucleus49.25
SuperiorCervicalGanglion34.05
TemporalLobe45.75
Testis371.65
TestisGermCell240
TestisIntersitial150.6
TestisLeydigCell155.4
TestisSeminiferousTubule143.5
Thalamus49.95
Thymus556.7
Thyroid172.15
Tongue64.25
Tonsil255.1
Trachea81.4
TrigeminalGanglion24.6
Uterus219
UterusCorpus70.4
WholeBlood484.5
Wholebrain211.4
colon158.2
pineal_day216.44
pineal_night239.08
retina145.05
small_intestine216.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15781_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.84 ± 0.41
Basal Forebrain7.42 ± 0.17
Basal Part of Pons7.53 ± 0.19
Cerebellar Cortex7.71 ± 0.22
Cerebellar Nuclei7.22 ± 0.29
Claustrum7.82 ± 0.49
Epithalamus7.53 ± 0.23
Frontal Lobe7.45 ± 0.25
Globus Pallidus7.14 ± 0.22
Hypothalamus7.57 ± 0.29
Insula7.57 ± 0.27
Limbic Lobe7.73 ± 0.25
Mesencephalon7.46 ± 0.29
Myelencephalon7.53 ± 0.26
Occipital Lobe7.67 ± 0.28
Parietal Lobe7.47 ± 0.27
Pontine Tegmentum7.54 ± 0.31
Striatum7.57 ± 0.24
Subthalamus7.15 ± 0.17
Temporal Lobe7.56 ± 0.28
Thalamus7.47 ± 0.24
White Matter7.64 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ube2iCBCerebellum13.78
19.09
Ube2iCTXCerebral cortex77.13
57.85
Ube2iHIPHippocampal region44.67
51.42
Ube2iHPFHippocampal formation50.1
49.44
Ube2iHYHypothalamus83.75
71.26
Ube2iLSXLateral septal complex72.5
60.85
Ube2iMBMidbrain38.12
36.33
Ube2iMYMedulla27.07
32.38
Ube2iOLFOlfactory bulb100
84.87
Ube2iPPons32.26
34.02
Ube2iPALPallidum62.55
55.14
Ube2iRHPRetrohippocampal region56.1
45.76
Ube2isAMYStriatum-like amygdalar nuclei78.43
63.91
Ube2iSTRStriatum62.21
47.16
Ube2iSTRdStriatum dorsal region56.23
40.35
Ube2iSTRvStriatum ventral region64.57
49.19
Ube2iTHThalamus81.36
67.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064721 9 66 74 DDYPSSPPK Peptide Atlas
UBC9_HUMAN_17 13 17 29 KDHPFGFVAVPTK PRIDE
UBC9_HUMAN_18 12 18 29 DHPFGFVAVPTK PRIDE
UBC9_HUMAN_2 7 2 8 SGIALSR PRIDE
UBC9_HUMAN_30 19 30 48 NPDGTMNLMNWECAIPGKK PRIDE
UBC9_HUMAN_48 11 48 58 KGTPWEGGLFK PRIDE
UBC9_HUMAN_49 10 49 58 GTPWEGGLFK PRIDE
UBC9_HUMAN_61 13 61 73 MLFKDDYPSSPPK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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