AutismKB 2.0

Annotation Detail for UBE2N


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Basic Information Top
Gene Symbol:UBE2N ( MGC131857,MGC8489,UBC13,UbcH-ben )
Gene Full Name: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
Band: 12q22
Quick LinksEntrez ID:7334; OMIM: 603679; Uniprot ID:UBE2N_HUMAN; ENSEMBL ID: ENSG00000177889; HGNC ID: 12492
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst8 / 62319128
fetus68 / 564012120
neonate2 / 3109764
infant4 / 23620169
juvenile2 / 5555635
adult163 / 193912184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor6 / 11936950
germ cell tumor44 / 263845166
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor10 / 68959145
leukemia5 / 9584252
liver tumor11 / 96359114
lung tumor8 / 10312777
lymphoma8 / 71755111
non-neoplasia6 / 9725061
normal380 / 3360307113
ovarian tumor11 / 76682143
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer6 / 10268058
retinoblastoma3 / 4635664
skin tumor13 / 124949104
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder5 / 29757168
blood10 / 12347880
bone9 / 71655125
bone marrow8 / 48801163
brain203 / 1100989184
cervix3 / 4817162
connective tissue7 / 14925546
ear2 / 16212123
embryonic tissue25 / 215722115
esophagus1 / 2020949
eye17 / 21105480
heart7 / 8962678
intestine19 / 23447281
kidney24 / 211777113
larynx3 / 24145124
liver15 / 20774372
lung32 / 33697494
lymph1 / 4427022
lymph node5 / 9161054
mammary gland7 / 15327145
mouth4 / 6705259
muscle6 / 10771555
nerve0 / 157680 
ovary9 / 10205188
pancreas15 / 21481269
parathyroid1 / 2053948
pharynx9 / 41328217
pituitary gland5 / 16585301
placenta14 / 28082549
prostate12 / 18934563
salivary gland1 / 2015549
skin22 / 210574104
spleen3 / 5395255
stomach2 / 9661920
testis48 / 330442145
thymus6 / 8113173
thyroid0 / 474730 
tonsil5 / 16999294
trachea6 / 52413114
umbilical cord1 / 1368073
uterus33 / 232878141
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212751_at
Cell line Expression level Expression bar
721_B_lymphoblasts142
Adipocyte15.35
AdrenalCortex15
Adrenalgland18.95
Amygdala122.25
Appendix16.3
AtrioventricularNode8.85
BDCA4+_DentriticCells52.5
Bonemarrow22.3
BronchialEpithelialCells20.9
CD105+_Endothelial23.55
CD14+_Monocytes24.85
CD19+_BCells(neg._sel.)134.95
CD33+_Myeloid59.95
CD34+43.7
CD4+_Tcells31.9
CD56+_NKCells80.55
CD71+_EarlyErythroid13.25
CD8+_Tcells33
CardiacMyocytes19.75
Caudatenucleus29.8
Cerebellum28.55
CerebellumPeduncles25.65
CiliaryGanglion11.25
CingulateCortex43.95
Colorectaladenocarcinoma16.8
DorsalRootGanglion16.9
FetalThyroid21.65
Fetalbrain85.8
Fetalliver17.35
Fetallung19.15
GlobusPallidus27.8
Heart7.2
Hypothalamus120.15
Kidney17.6
Leukemia_chronicMyelogenousK-56234
Leukemia_promyelocytic-HL-6038.7
Leukemialymphoblastic(MOLT-4)26.5
Liver8.7
Lung10.9
Lymphnode19.85
Lymphoma_burkitts(Daudi)42.15
Lymphoma_burkitts(Raji)31.25
MedullaOblongata58.3
OccipitalLobe51
OlfactoryBulb17.65
Ovary14.8
Pancreas13.95
PancreaticIslet23.8
ParietalLobe24.45
Pituitary29.6
Placenta27.1
Pons24.45
PrefrontalCortex77.55
Prostate25.45
Salivarygland17.9
SkeletalMuscle20.95
Skin16.65
SmoothMuscle19.05
Spinalcord35.95
SubthalamicNucleus27.75
SuperiorCervicalGanglion30.2
TemporalLobe30.5
Testis25.8
TestisGermCell20.6
TestisIntersitial9.75
TestisLeydigCell14.85
TestisSeminiferousTubule19.15
Thalamus34.45
Thymus17.95
Thyroid28.25
Tongue21.8
Tonsil18.1
Trachea19.3
TrigeminalGanglion22.35
Uterus13.6
UterusCorpus14.55
WholeBlood28.5
Wholebrain73.8
colon28.15
pineal_day125.04
pineal_night113.78
retina80.7
small_intestine28.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P341471
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.58 ± 0.36
Basal Forebrain8.6 ± 0.12
Basal Part of Pons8.9 ± 0.12
Cerebellar Cortex8.61 ± 0.21
Cerebellar Nuclei9.04 ± 0.26
Claustrum8.7 ± 0.34
Epithalamus8.57 ± 0.24
Frontal Lobe8.8 ± 0.26
Globus Pallidus8.48 ± 0.3
Hypothalamus8.93 ± 0.17
Insula8.83 ± 0.26
Limbic Lobe8.66 ± 0.37
Mesencephalon8.71 ± 0.37
Myelencephalon8.66 ± 0.32
Occipital Lobe8.4 ± 0.36
Parietal Lobe8.7 ± 0.25
Pontine Tegmentum8.66 ± 0.29
Striatum8.19 ± 0.37
Subthalamus8.88 ± 0.42
Temporal Lobe8.78 ± 0.22
Thalamus8.69 ± 0.2
White Matter8.33 ± 0.08
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ube2nCBCerebellum25.15
30.07
Ube2nCTXCerebral cortex78.19
70.21
Ube2nHIPHippocampal region55.57
90.31
Ube2nHPFHippocampal formation63.19
82.44
Ube2nHYHypothalamus36.54
31.65
Ube2nLSXLateral septal complex53.39
43.74
Ube2nMBMidbrain45.21
46.78
Ube2nMYMedulla60.17
79.5
Ube2nOLFOlfactory bulb61.31
57.4
Ube2nPPons50.65
64.17
Ube2nPALPallidum48.91
51.48
Ube2nRHPRetrohippocampal region77.39
74.63
Ube2nsAMYStriatum-like amygdalar nuclei36.19
28.13
Ube2nSTRStriatum26.43
21.28
Ube2nSTRdStriatum dorsal region21.69
18.21
Ube2nSTRvStriatum ventral region28.12
20.26
Ube2nTHThalamus48.04
46.15
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00034708 18 36 53 HVVIAGPQDSPFEGGTFK Peptide Atlas
UBE2N_HUMAN_0 0 0 0 ICLDILK PRIDE
UBE2N_HUMAN_0 0 0 0 IYHPNVDKLGR PRIDE
UBE2N_HUMAN_0 0 0 0 LELFLPEEYPMAAPK PRIDE
UBE2N_HUMAN_0 0 0 0 TNEAQAIETAR PRIDE
UBE2N_HUMAN_0 0 0 0 YFHVVIAGPQDSPFEGGTFK PRIDE
UBE2N_HUMAN_102 28 102 129 TVLLSIQALLSAPNPDDPLANDVAEQWK PRIDE
UBE2N_HUMAN_130 11 130 140 TNEAQAIETAR PRIDE
UBE2N_HUMAN_131 11 131 141 TNEAQAIETAR PRIDE
UBE2N_HUMAN_14 10 14 23 LLAEPVPGIK PRIDE
UBE2N_HUMAN_14 19 14 32 LLAEPVPGIKAEPDESNAR PRIDE
UBE2N_HUMAN_33 20 33 52 YFHVVIAGPQDSPFEGGTFK PRIDE
UBE2N_HUMAN_53 15 53 67 LELFLPEEYPMAAPK PRIDE
UBE2N_HUMAN_74 11 74 84 IYHPNVDKLGR PRIDE
UBE2N_HUMAN_85 17 85 101 ICLDILKDKWSPALQIR PRIDE
UBE2N_HUMAN_85 7 85 91 ICLDILK PRIDE
UBE2N_HUMAN_92 10 92 101 DKWSPALQIR PRIDE
UBE2N_HUMAN_94 8 94 101 WSPALQIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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