AutismKB 2.0

Annotation Detail for VARS


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Basic Information Top
Gene Symbol:VARS ( G7A,VARS1,VARS2 )
Gene Full Name: valyl-tRNA synthetase
Band: 6p21.33
Quick LinksEntrez ID:7407; OMIM: 192150; Uniprot ID:SYVC_HUMAN; ENSEMBL ID: ENSG00000204394; HGNC ID: 12651
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst19 / 62319304
fetus59 / 564012104
neonate0 / 310970 
infant2 / 2362084
juvenile5 / 5555689
adult150 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor6 / 34366174
chondrosarcoma10 / 82823120
colorectal tumor24 / 114246210
esophageal tumor0 / 172900 
gastrointestinal tumor18 / 119369150
germ cell tumor36 / 263845136
glioma28 / 106883261
head and neck tumor12 / 13630288
kidney tumor6 / 6895987
leukemia14 / 95842146
liver tumor12 / 96359124
lung tumor19 / 103127184
lymphoma26 / 71755362
non-neoplasia5 / 9725051
normal329 / 336030797
ovarian tumor15 / 76682195
pancreatic tumor29 / 104616277
primitive neuroectodermal tumor of the CNS60 / 125680477
prostate cancer12 / 102680116
retinoblastoma10 / 46356215
skin tumor55 / 124949440
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites6 / 40015149
bladder1 / 2975733
blood23 / 123478186
bone12 / 71655167
bone marrow5 / 48801102
brain142 / 1100989128
cervix7 / 48171145
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue39 / 215722180
esophagus0 / 202090 
eye37 / 211054175
heart1 / 8962611
intestine50 / 234472213
kidney24 / 211777113
larynx0 / 241450 
liver23 / 207743110
lung29 / 33697486
lymph22 / 44270496
lymph node18 / 91610196
mammary gland11 / 15327171
mouth5 / 6705274
muscle3 / 10771527
nerve0 / 157680 
ovary25 / 102051244
pancreas36 / 214812167
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta19 / 28082567
prostate18 / 18934595
salivary gland0 / 201550 
skin59 / 210574280
spleen2 / 5395237
stomach16 / 96619165
testis45 / 330442136
thymus6 / 8113173
thyroid6 / 47473126
tonsil2 / 16999117
trachea2 / 5241338
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201797_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts218.4
Adipocyte7.85
AdrenalCortex7.8
Adrenalgland5.9
Amygdala8.5
Appendix6.95
AtrioventricularNode5.2
BDCA4+_DentriticCells33.4
Bonemarrow6.55
BronchialEpithelialCells20.3
CD105+_Endothelial24.25
CD14+_Monocytes17
CD19+_BCells(neg._sel.)26.55
CD33+_Myeloid15.65
CD34+20.55
CD4+_Tcells12.2
CD56+_NKCells12.4
CD71+_EarlyErythroid7.35
CD8+_Tcells11.5
CardiacMyocytes13.55
Caudatenucleus6.5
Cerebellum5.5
CerebellumPeduncles8.75
CiliaryGanglion4.95
CingulateCortex6.9
Colorectaladenocarcinoma17.15
DorsalRootGanglion4.9
FetalThyroid8.8
Fetalbrain9.65
Fetalliver6.25
Fetallung6.65
GlobusPallidus5.2
Heart10.05
Hypothalamus9.25
Kidney5.5
Leukemia_chronicMyelogenousK-56246.15
Leukemia_promyelocytic-HL-6023.8
Leukemialymphoblastic(MOLT-4)13.75
Liver19.8
Lung28.15
Lymphnode7.9
Lymphoma_burkitts(Daudi)15.65
Lymphoma_burkitts(Raji)103.25
MedullaOblongata6.4
OccipitalLobe6.05
OlfactoryBulb4.85
Ovary4.9
Pancreas10.1
PancreaticIslet14.65
ParietalLobe7.45
Pituitary12.65
Placenta9.15
Pons7.25
PrefrontalCortex9.95
Prostate10.4
Salivarygland4.8
SkeletalMuscle9.15
Skin5.1
SmoothMuscle23.8
Spinalcord7.1
SubthalamicNucleus7.15
SuperiorCervicalGanglion8.5
TemporalLobe6.2
Testis48.95
TestisGermCell31.95
TestisIntersitial42.75
TestisLeydigCell10.85
TestisSeminiferousTubule27.4
Thalamus8.1
Thymus8.05
Thyroid17.3
Tongue7.05
Tonsil7.1
Trachea5.45
TrigeminalGanglion6.85
Uterus8.55
UterusCorpus6.2
WholeBlood9.4
Wholebrain9.45
colon6.45
pineal_day10.3
pineal_night12.22
retina10.7
small_intestine6.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7771_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.63 ± 0.48
Basal Forebrain3.37 ± 0.82
Basal Part of Pons4.19 ± 0.56
Cerebellar Cortex3.83 ± 0.74
Cerebellar Nuclei3.51 ± 0.4
Claustrum3.11 ± 0.77
Epithalamus3.37 ± 0.75
Frontal Lobe3.89 ± 0.58
Globus Pallidus2.99 ± 0.44
Hypothalamus3.59 ± 0.63
Insula3.85 ± 0.47
Limbic Lobe3.63 ± 0.71
Mesencephalon3.48 ± 0.62
Myelencephalon3.75 ± 0.62
Occipital Lobe3.13 ± 0.73
Parietal Lobe3.8 ± 0.57
Pontine Tegmentum3.55 ± 0.66
Striatum3.2 ± 0.61
Subthalamus3.66 ± 0.87
Temporal Lobe3.79 ± 0.6
Thalamus3.63 ± 0.56
White Matter3.65 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vars2CBCerebellum18.69
20.22
Vars2CTXCerebral cortex28.15
19.2
Vars2HIPHippocampal region24.47
24.61
Vars2HPFHippocampal formation24.65
22.01
Vars2HYHypothalamus39.61
29.1
Vars2LSXLateral septal complex22.91
15.36
Vars2MBMidbrain20.46
18.65
Vars2MYMedulla26.89
33.86
Vars2OLFOlfactory bulb39.2
29.69
Vars2PPons33.57
39.23
Vars2PALPallidum30.41
26.06
Vars2RHPRetrohippocampal region25.39
18.3
Vars2sAMYStriatum-like amygdalar nuclei17.81
12.24
Vars2STRStriatum12.36
9.11
Vars2STRdStriatum dorsal region6.42
5.03
Vars2STRvStriatum ventral region25.67
18.15
Vars2THThalamus22.66
16.76
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001001 14 682 695 CGEMAQAASAAVTR Peptide Atlas
SYVC_HUMAN_1058 16 1058 1073 LLSPFMPFVTEELFQR PRIDE
SYVC_HUMAN_122 15 122 136 SSAQDPQAVLGALGR PRIDE
SYVC_HUMAN_123 15 123 137 SSAQDPQAVLGALGR PRIDE
SYVC_HUMAN_2 16 2 17 STLYVSPHPDAFPSLR PRIDE
SYVC_HUMAN_215 27 215 241 PLSHQPGPEAPALPKTAAQLKKEAKKR PRIDE
SYVC_HUMAN_23 16 23 38 YGEAGEGPGWGGAHPR PRIDE
SYVC_HUMAN_290 14 290 303 KDVSGPMPDSYSPR PRIDE
SYVC_HUMAN_291 13 291 303 DVSGPMPDSYSPR PRIDE
SYVC_HUMAN_326 9 326 334 PNVSAANPR PRIDE
SYVC_HUMAN_473 20 473 492 LVNWSCTLNSAISDIEVDKK PRIDE
SYVC_HUMAN_537 15 537 551 IETMLGDVAVAVHPK PRIDE
SYVC_HUMAN_538 15 538 552 IETMLGDVAVAVHPK PRIDE
SYVC_HUMAN_591 15 591 605 ITPAHDQNDYEVGQR PRIDE
SYVC_HUMAN_607 12 607 618 HGLEAISIMDSR PRIDE
SYVC_HUMAN_618 15 618 632 GALINVPPPFLGLPR PRIDE
SYVC_HUMAN_682 14 682 695 CGEMAQAASAAVTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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