Annotation Detail for VAV2
Basic Information Top
| Gene Symbol: | VAV2 ( - ) |
|---|---|
| Gene Full Name: | vav 2 guanine nucleotide exchange factor |
| Band: | 9q34.2 |
| Quick Links | Entrez ID:7410; OMIM: 600428; Uniprot ID:VAV2_HUMAN; ENSEMBL ID: ENSG00000160293; HGNC ID: 12658 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.369921
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 4 / 70761 | 56 |  |
| blastocyst | 5 / 62319 | 80 | |
| fetus | 22 / 564012 | 39 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 33 / 1939121 | 17 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 1 / 12794 | 78 | |
| bladder carcinoma | 2 / 17475 | 114 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 |  |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 4 / 114246 | 35 | |
| esophageal tumor | 3 / 17290 | 173 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 14 / 263845 | 53 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 3 / 136302 | 22 | |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 8 / 95842 | 83 | |
| liver tumor | 3 / 96359 | 31 | |
| lung tumor | 2 / 103127 | 19 | |
| lymphoma | 1 / 71755 | 13 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 82 / 3360307 | 24 | |
| ovarian tumor | 6 / 76682 | 78 | |
| pancreatic tumor | 2 / 104616 | 19 | |
| primitive neuroectodermal tumor of the CNS | 5 / 125680 | 39 | |
| prostate cancer | 2 / 102680 | 19 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 4 / 125191 | 31 | |
| uterine tumor | 2 / 90257 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 1 / 29757 | 33 | |
| blood | 1 / 123478 | 8 | |
| bone | 3 / 71655 | 41 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 19 / 1100989 | 17 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 1 / 16212 | 61 | |
| embryonic tissue | 11 / 215722 | 50 | |
| esophagus | 3 / 20209 | 148 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 9 / 234472 | 38 | |
| kidney | 10 / 211777 | 47 | |
| larynx | 1 / 24145 | 41 | |
| liver | 4 / 207743 | 19 | |
| lung | 4 / 336974 | 11 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 14 / 91610 | 152 | |
| mammary gland | 4 / 153271 | 26 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 2 / 15768 | 126 | |
| ovary | 6 / 102051 | 58 | |
| pancreas | 6 / 214812 | 27 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 3 / 189345 | 15 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 3 / 210574 | 14 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 11 / 330442 | 33 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 7 / 232878 | 30 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 205536_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.95 | |
| Adipocyte | 6.2 | |
| AdrenalCortex | 7.25 | |
| Adrenalgland | 7.4 | |
| Amygdala | 7.05 | |
| Appendix | 6.6 | |
| AtrioventricularNode | 7.35 | |
| BDCA4+_DentriticCells | 7.6 | |
| Bonemarrow | 6.95 | |
| BronchialEpithelialCells | 6.55 | |
| CD105+_Endothelial | 6.4 | |
| CD14+_Monocytes | 10.95 | |
| CD19+_BCells(neg._sel.) | 17.3 | |
| CD33+_Myeloid | 9.2 | |
| CD34+ | 8.1 | |
| CD4+_Tcells | 6.95 | |
| CD56+_NKCells | 7.85 | |
| CD71+_EarlyErythroid | 6.15 | |
| CD8+_Tcells | 6.4 | |
| CardiacMyocytes | 8.35 | |
| Caudatenucleus | 5.95 | |
| Cerebellum | 6.4 | |
| CerebellumPeduncles | 7.55 | |
| CiliaryGanglion | 4.6 | |
| CingulateCortex | 6.7 | |
| Colorectaladenocarcinoma | 7.35 | |
| DorsalRootGanglion | 5.05 | |
| FetalThyroid | 6.45 | |
| Fetalbrain | 8.8 | |
| Fetalliver | 5.65 | |
| Fetallung | 5.55 | |
| GlobusPallidus | 4.75 | |
| Heart | 8.65 | |
| Hypothalamus | 7.15 | |
| Kidney | 5.45 | |
| Leukemia_chronicMyelogenousK-562 | 5.8 | |
| Leukemia_promyelocytic-HL-60 | 5.55 | |
| Leukemialymphoblastic(MOLT-4) | 5.35 | |
| Liver | 8.75 | |
| Lung | 7.4 | |
| Lymphnode | 5.8 | |
| Lymphoma_burkitts(Daudi) | 8.45 | |
| Lymphoma_burkitts(Raji) | 9.9 | |
| MedullaOblongata | 6.1 | |
| OccipitalLobe | 6.4 | |
| OlfactoryBulb | 5.05 | |
| Ovary | 4.35 | |
| Pancreas | 5.85 | |
| PancreaticIslet | 7.55 | |
| ParietalLobe | 6.9 | |
| Pituitary | 8.15 | |
| Placenta | 6.7 | |
| Pons | 8.85 | |
| PrefrontalCortex | 7.25 | |
| Prostate | 8.65 | |
| Salivarygland | 5 | |
| SkeletalMuscle | 7.5 | |
| Skin | 4.9 | |
| SmoothMuscle | 7.6 | |
| Spinalcord | 7.05 | |
| SubthalamicNucleus | 5.9 | |
| SuperiorCervicalGanglion | 9.9 | |
| TemporalLobe | 6 | |
| Testis | 6.15 | |
| TestisGermCell | 5.5 | |
| TestisIntersitial | 5.55 | |
| TestisLeydigCell | 6.5 | |
| TestisSeminiferousTubule | 5.6 | |
| Thalamus | 6.7 | |
| Thymus | 5.25 | |
| Thyroid | 8.6 | |
| Tongue | 6.4 | |
| Tonsil | 6.4 | |
| Trachea | 5.55 | |
| TrigeminalGanglion | 6.65 | |
| Uterus | 5.2 | |
| UterusCorpus | 6.05 | |
| WholeBlood | 7.15 | |
| Wholebrain | 5.8 | |
| colon | 6.65 | |
| pineal_day | 8.5 | |
| pineal_night | 8.08 | |
| retina | 8.025 | |
| small_intestine | 6.5 | |
- Probe name: A_23_P146468
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.49 ± 1.21 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.23 ± 0.48 | |
| Basal Part of Pons | 1.66 ± 0.66 | |
| Cerebellar Cortex | 2.06 ± 0.96 | |
| Cerebellar Nuclei | 2.41 ± 0.86 | |
| Claustrum | 3.1 ± 0.91 | |
| Epithalamus | 2.25 ± 0.6 | |
| Frontal Lobe | 2.12 ± 0.82 | |
| Globus Pallidus | 2.77 ± 0.53 | |
| Hypothalamus | 2.51 ± 0.65 | |
| Insula | 1.86 ± 0.93 | |
| Limbic Lobe | 2.19 ± 0.8 | |
| Mesencephalon | 2.62 ± 0.9 | |
| Myelencephalon | 2.27 ± 0.81 | |
| Occipital Lobe | 2.22 ± 1.02 | |
| Parietal Lobe | 2.27 ± 1.07 | |
| Pontine Tegmentum | 2.21 ± 0.83 | |
| Striatum | 2.09 ± 0.7 | |
| Subthalamus | 2.11 ± 0.75 | |
| Temporal Lobe | 2.18 ± 0.87 | |
| Thalamus | 2.09 ± 0.75 | |
| White Matter | 2.13 ± 0.3 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Vav2 | CB | Cerebellum | 3.67 | |
| 4.66 | | |||
| Vav2 | CTX | Cerebral cortex | 3.99 | |
| 3.19 | | |||
| Vav2 | HIP | Hippocampal region | 6.23 | |
| 6.4 | | |||
| Vav2 | HPF | Hippocampal formation | 4.43 | |
| 4.17 | | |||
| Vav2 | HY | Hypothalamus | 0.68 | |
| 0.56 | | |||
| Vav2 | LSX | Lateral septal complex | 1.15 | |
| 2.04 | | |||
| Vav2 | MB | Midbrain | 4.51 | |
| 4.72 | | |||
| Vav2 | MY | Medulla | 4.3 | |
| 4.86 | | |||
| Vav2 | OLF | Olfactory bulb | 6.68 | |
| 5.55 | | |||
| Vav2 | P | Pons | 5.42 | |
| 5.31 | | |||
| Vav2 | PAL | Pallidum | 1.62 | |
| 1.76 | | |||
| Vav2 | RHP | Retrohippocampal region | 2.19 | |
| 1.76 | | |||
| Vav2 | sAMY | Striatum-like amygdalar nuclei | 1.06 | |
| 1.1 | | |||
| Vav2 | STR | Striatum | 1.11 | |
| 1.29 | | |||
| Vav2 | STRd | Striatum dorsal region | 1 | |
| 1.23 | | |||
| Vav2 | STRv | Striatum ventral region | 1.04 | |
| 0.86 | | |||
| Vav2 | TH | Thalamus | 4.2 | |
| 9.93 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00024646 | 20 | 39 | 58 | DGVLLCQLLHNLSPGSIDLK | Peptide Atlas |