AutismKB 2.0

Annotation Detail for VCL


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Basic Information Top
Gene Symbol:VCL ( CMD1W,CMH15,MVCL )
Gene Full Name: vinculin
Band: 10q22.2
Quick LinksEntrez ID:7414; OMIM: 193065; Uniprot ID:VINC_HUMAN; ENSEMBL ID: ENSG00000035403; HGNC ID: 12665
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body32 / 70761452
blastocyst31 / 62319497
fetus63 / 564012111
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult354 / 1939121182
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor7 / 9417874
cervical tumor2 / 3436658
chondrosarcoma18 / 82823217
colorectal tumor25 / 114246218
esophageal tumor4 / 17290231
gastrointestinal tumor29 / 119369242
germ cell tumor54 / 263845204
glioma3 / 10688328
head and neck tumor40 / 136302293
kidney tumor11 / 68959159
leukemia19 / 95842198
liver tumor14 / 96359145
lung tumor10 / 10312796
lymphoma0 / 717550 
non-neoplasia10 / 97250102
normal476 / 3360307141
ovarian tumor15 / 76682195
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer15 / 102680146
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland2 / 3319760
ascites17 / 40015424
bladder5 / 29757168
blood12 / 12347897
bone20 / 71655279
bone marrow10 / 48801204
brain93 / 110098984
cervix2 / 4817141
connective tissue20 / 149255133
ear3 / 16212185
embryonic tissue82 / 215722380
esophagus4 / 20209197
eye19 / 21105490
heart9 / 89626100
intestine39 / 234472166
kidney21 / 21177799
larynx6 / 24145248
liver22 / 207743105
lung38 / 336974112
lymph0 / 442700 
lymph node13 / 91610141
mammary gland18 / 153271117
mouth31 / 67052462
muscle16 / 107715148
nerve2 / 15768126
ovary21 / 102051205
pancreas21 / 21481297
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta55 / 280825195
prostate21 / 189345110
salivary gland4 / 20155198
skin18 / 21057485
spleen3 / 5395255
stomach12 / 96619124
testis104 / 330442314
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea30 / 52413572
umbilical cord0 / 136800 
uterus95 / 232878407
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200931_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts428.7
Adipocyte743.05
AdrenalCortex44.5
Adrenalgland18.25
Amygdala23.75
Appendix421.2
AtrioventricularNode56.95
BDCA4+_DentriticCells612.35
Bonemarrow142.3
BronchialEpithelialCells338.5
CD105+_Endothelial61.8
CD14+_Monocytes824.4
CD19+_BCells(neg._sel.)199.1
CD33+_Myeloid1182.75
CD34+494.6
CD4+_Tcells157.85
CD56+_NKCells974.9
CD71+_EarlyErythroid6.75
CD8+_Tcells186.75
CardiacMyocytes648.15
Caudatenucleus25.2
Cerebellum20.55
CerebellumPeduncles10.7
CiliaryGanglion153
CingulateCortex17.85
Colorectaladenocarcinoma105.95
DorsalRootGanglion83.85
FetalThyroid243.3
Fetalbrain28.45
Fetalliver33.8
Fetallung252.5
GlobusPallidus18.55
Heart52.85
Hypothalamus32.7
Kidney45.2
Leukemia_chronicMyelogenousK-562359.2
Leukemia_promyelocytic-HL-6015.9
Leukemialymphoblastic(MOLT-4)13
Liver18.6
Lung240.85
Lymphnode95.15
Lymphoma_burkitts(Daudi)18.75
Lymphoma_burkitts(Raji)59.1
MedullaOblongata43.7
OccipitalLobe22.4
OlfactoryBulb252.6
Ovary121.25
Pancreas65.45
PancreaticIslet60.95
ParietalLobe19.65
Pituitary63.9
Placenta432.85
Pons20.9
PrefrontalCortex23.9
Prostate331.95
Salivarygland38.1
SkeletalMuscle110.35
Skin98.55
SmoothMuscle747.5
Spinalcord51.8
SubthalamicNucleus24.55
SuperiorCervicalGanglion117
TemporalLobe18.3
Testis176.45
TestisGermCell733
TestisIntersitial167.1
TestisLeydigCell226.3
TestisSeminiferousTubule221.35
Thalamus14.45
Thymus23.1
Thyroid180.1
Tongue97.9
Tonsil84.2
Trachea131.2
TrigeminalGanglion80.15
Uterus845.25
UterusCorpus338.2
WholeBlood310.55
Wholebrain13.95
colon612.05
pineal_day93.6
pineal_night94.02
retina369.475
small_intestine425.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P202280
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.04 ± 0.53
Basal Forebrain4.93 ± 0.39
Basal Part of Pons5.09 ± 0.32
Cerebellar Cortex4.83 ± 0.32
Cerebellar Nuclei5.58 ± 0.39
Claustrum5.15 ± 0.66
Epithalamus4.97 ± 0.52
Frontal Lobe5.43 ± 0.4
Globus Pallidus4.82 ± 0.63
Hypothalamus5.56 ± 0.38
Insula5.39 ± 0.39
Limbic Lobe5.11 ± 0.4
Mesencephalon5.1 ± 0.51
Myelencephalon5.14 ± 0.41
Occipital Lobe4.96 ± 0.36
Parietal Lobe5.31 ± 0.41
Pontine Tegmentum5.3 ± 0.47
Striatum5.02 ± 0.44
Subthalamus5.51 ± 0.27
Temporal Lobe5.13 ± 0.3
Thalamus5.01 ± 0.38
White Matter4.16 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
VclCBCerebellum0.41
0.47
VclCTXCerebral cortex0.57
0.85
VclHIPHippocampal region1.8
1.71
VclHPFHippocampal formation1.31
1.4
VclHYHypothalamus0.78
0.54
VclLSXLateral septal complex0.47
0.43
VclMBMidbrain0.26
0.58
VclMYMedulla1.38
1.51
VclOLFOlfactory bulb1.86
2.88
VclPPons1.09
1.38
VclPALPallidum1.12
0.77
VclRHPRetrohippocampal region0.45
0.96
VclsAMYStriatum-like amygdalar nuclei0.39
0.32
VclSTRStriatum0.71
0.57
VclSTRdStriatum dorsal region0.42
0.42
VclSTRvStriatum ventral region1.85
1.17
VclTHThalamus0.82
1.44
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000907 17 545 561 CDRVDQLTAQLADLAAR Peptide Atlas
VINC_HUMAN_0 0 0 0 AIPDLTAPVAAVQAAVSNLVR PRIDE
VINC_HUMAN_0 0 0 0 ALAKQVATALQNLQTKTNR PRIDE
VINC_HUMAN_0 0 0 0 ALASQLQDSLK PRIDE
VINC_HUMAN_0 0 0 0 AQQVSQGLDVLTAK PRIDE
VINC_HUMAN_0 0 0 0 AVAGNISDPGLQK PRIDE
VINC_HUMAN_0 0 0 0 ELLPVLISAMK PRIDE
VINC_HUMAN_0 0 0 0 ELTPQVVSAAR PRIDE
VINC_HUMAN_0 0 0 0 LLAVAATAPPDAPNREEVFDER PRIDE
VINC_HUMAN_0 0 0 0 SLGEISALTSK PRIDE
VINC_HUMAN_0 0 0 0 STVEGIQASVK PRIDE
VINC_HUMAN_1 6 1 6 PVFHTR PRIDE
VINC_HUMAN_1046 18 1046 1063 TNLLQVCERIPTISTQLK PRIDE
VINC_HUMAN_1046 9 1046 1054 TNLLQVCER PRIDE
VINC_HUMAN_1055 9 1055 1063 IPTISTQLK PRIDE
VINC_HUMAN_1056 9 1056 1064 IPTISTQLK PRIDE
VINC_HUMAN_1103 12 1103 1114 ETVREAEAASIK PRIDE
VINC_HUMAN_1115 10 1115 1124 IRTDAGFTLR PRIDE
VINC_HUMAN_1117 8 1117 1124 TDAGFTLR PRIDE
VINC_HUMAN_113 19 113 131 GILSGTSDLLLTFDEAEVR PRIDE
VINC_HUMAN_113 20 113 132 GILSGTSDLLLTFDEAEVRK PRIDE
VINC_HUMAN_114 19 114 132 GILSGTSDLLLTFDEAEVR PRIDE
VINC_HUMAN_139 23 139 161 GILEYLTVAEVVETMEDLVTYTK PRIDE
VINC_HUMAN_173 15 173 187 MIDERQQELTHQEHR PRIDE
VINC_HUMAN_178 10 178 187 QQELTHQEHR PRIDE
VINC_HUMAN_179 10 179 188 QQELTHQEHR PRIDE
VINC_HUMAN_188 11 188 198 VMLVNSMNTVK PRIDE
VINC_HUMAN_188 22 188 209 VMLVNSMNTVKELLPVLISAMK PRIDE
VINC_HUMAN_188 28 188 215 VMLVNSMNTVKELLPVLISAMKIFVTTK PRIDE
VINC_HUMAN_199 11 199 209 ELLPVLISAMK PRIDE
VINC_HUMAN_219 11 219 229 NQGIEEALKNR PRIDE
VINC_HUMAN_230 16 230 245 NFTVEKMSAEINEIIR PRIDE
VINC_HUMAN_231 16 231 246 NFTVEKMSAEINEIIR PRIDE
VINC_HUMAN_236 10 236 245 MSAEINEIIR PRIDE
VINC_HUMAN_246 15 246 260 VLQLTSWDEDAWASK PRIDE
VINC_HUMAN_246 22 246 267 VLQLTSWDEDAWASKDTEAMKR PRIDE
VINC_HUMAN_247 15 247 261 VLQLTSWDEDAWASK PRIDE
VINC_HUMAN_268 13 268 280 ALASIDSKLNQAK PRIDE
VINC_HUMAN_281 19 281 299 GWLRDPSASPGDAGEQAIR PRIDE
VINC_HUMAN_285 15 285 299 DPSASPGDAGEQAIR PRIDE
VINC_HUMAN_286 14 286 299 PSASPGDAGEQAIR PRIDE
VINC_HUMAN_286 15 286 300 DPSASPGDAGEQAIR PRIDE
VINC_HUMAN_300 16 300 315 QILDEAGKVGELCAGK PRIDE
VINC_HUMAN_300 18 300 317 QILDEAGKVGELCAGKER PRIDE
VINC_HUMAN_326 13 326 338 MLGQMTDQVADLR PRIDE
VINC_HUMAN_341 11 341 351 GQGSSPVAMQK PRIDE
VINC_HUMAN_342 11 342 352 GQGSSPVAMQK PRIDE
VINC_HUMAN_35 21 35 55 AIPDLTAPVAAVQAAVSNLVR PRIDE
VINC_HUMAN_350 22 350 371 QKAQQVSQGLDVLTAKVENAAR PRIDE
VINC_HUMAN_352 14 352 365 AQQVSQGLDVLTAK PRIDE
VINC_HUMAN_352 20 352 371 AQQVSQGLDVLTAKVENAAR PRIDE
VINC_HUMAN_353 14 353 366 AQQVSQGLDVLTAK PRIDE
VINC_HUMAN_36 21 36 56 AIPDLTAPVAAVQAAVSNLVR PRIDE
VINC_HUMAN_372 9 372 380 KLEAMTNSK PRIDE
VINC_HUMAN_386 23 386 408 KIDAAQNWLADPNGGPEGEEQIR PRIDE
VINC_HUMAN_387 23 387 409 KIDAAQNWLADPNGGPEGEEQIR PRIDE
VINC_HUMAN_388 22 388 409 IDAAQNWLADPNGGPEGEEQIR PRIDE
VINC_HUMAN_433 11 433 443 SLGEISALTSK PRIDE
VINC_HUMAN_434 11 434 444 SLGEISALTSK PRIDE
VINC_HUMAN_464 12 464 475 QVATALQNLQTK PRIDE
VINC_HUMAN_465 12 465 476 QVATALQNLQTK PRIDE
VINC_HUMAN_480 9 480 488 AVANSRPAK PRIDE
VINC_HUMAN_485 17 485 501 PAKAAVHLEGKIEQAQR PRIDE
VINC_HUMAN_488 14 488 501 AAVHLEGKIEQAQR PRIDE
VINC_HUMAN_502 10 502 511 WIDNPTVDDR PRIDE
VINC_HUMAN_502 18 502 519 WIDNPTVDDRGVGQAAIR PRIDE
VINC_HUMAN_503 10 503 512 WIDNPTVDDR PRIDE
VINC_HUMAN_528 10 528 537 LANVMMGPYR PRIDE
VINC_HUMAN_528 16 528 543 LANVMMGPYRQDLLAK PRIDE
VINC_HUMAN_544 17 544 560 CDRVDQLTAQLADLAAR PRIDE
VINC_HUMAN_545 17 545 561 CDRVDQLTAQLADLAAR PRIDE
VINC_HUMAN_547 14 547 560 VDQLTAQLADLAAR PRIDE
VINC_HUMAN_548 14 548 561 VDQLTAQLADLAAR PRIDE
VINC_HUMAN_56 15 56 70 VGKETVQTTEDQILK PRIDE
VINC_HUMAN_56 16 56 71 VGKETVQTTEDQILKR PRIDE
VINC_HUMAN_570 11 570 580 ALASQLQDSLK PRIDE
VINC_HUMAN_570 14 570 583 ALASQLQDSLKDLK PRIDE
VINC_HUMAN_571 11 571 581 ALASQLQDSLK PRIDE
VINC_HUMAN_586 21 586 606 MQEAMTQEVSDVFSDTTTPIK PRIDE
VINC_HUMAN_59 12 59 70 ETVQTTEDQILK PRIDE
VINC_HUMAN_59 13 59 71 ETVQTTEDQILKR PRIDE
VINC_HUMAN_607 22 607 628 LLAVAATAPPDAPNREEVFDER PRIDE
VINC_HUMAN_608 22 608 629 LLAVAATAPPDAPNREEVFDER PRIDE
VINC_HUMAN_655 11 655 665 STVEGIQASVK PRIDE
VINC_HUMAN_656 11 656 666 STVEGIQASVK PRIDE
VINC_HUMAN_669 11 669 679 ELTPQVVSAAR PRIDE
VINC_HUMAN_670 11 670 680 ELTPQVVSAAR PRIDE
VINC_HUMAN_680 19 680 698 ILLRNPGNQAAYEHFETMK PRIDE
VINC_HUMAN_684 15 684 698 NPGNQAAYEHFETMK PRIDE
VINC_HUMAN_7 28 7 34 TIESILEPVAQQISHLVIMHEEGEVDGK PRIDE
VINC_HUMAN_708 12 708 719 MTGLVDEAIDTK PRIDE
VINC_HUMAN_72 15 72 86 DMPPAFIKVENACTK PRIDE
VINC_HUMAN_72 8 72 79 DMPPAFIK PRIDE
VINC_HUMAN_720 12 720 731 SLLDASEEAIKK PRIDE
VINC_HUMAN_721 11 721 731 SLLDASEEAIK PRIDE
VINC_HUMAN_738 20 738 757 VAMANIQPQMLVAGATSIAR PRIDE
VINC_HUMAN_739 20 739 758 VAMANIQPQMLVAGATSIAR PRIDE
VINC_HUMAN_785 18 785 802 AASDELSKTISPMVMDAK PRIDE
VINC_HUMAN_792 10 792 801 TISPMVMDAK PRIDE
VINC_HUMAN_793 10 793 802 TISPMVMDAK PRIDE
VINC_HUMAN_8 28 8 35 TIESILEPVAQQISHLVIMHEEGEVDGK PRIDE
VINC_HUMAN_802 13 802 814 AVAGNISDPGLQK PRIDE
VINC_HUMAN_803 13 803 815 AVAGNISDPGLQK PRIDE
VINC_HUMAN_815 8 815 822 SFLDSGYR PRIDE
VINC_HUMAN_816 8 816 823 SFLDSGYR PRIDE
VINC_HUMAN_830 23 830 852 VREAFQPQEPDFPPPPPDLEQLR PRIDE
VINC_HUMAN_832 21 832 852 EAFQPQEPDFPPPPPDLEQLR PRIDE
VINC_HUMAN_87 18 87 104 LVQAAQMLQSDPYSVPAR PRIDE
VINC_HUMAN_87 26 87 112 LVQAAQMLQSDPYSVPARDYLIDGSR PRIDE
VINC_HUMAN_88 18 88 105 LVQAAQMLQSDPYSVPAR PRIDE
VINC_HUMAN_889 14 889 902 AGEVINQPMMMAAR PRIDE
VINC_HUMAN_993 10 993 1002 MALLMAEMSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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