AutismKB 2.0

Annotation Detail for VRK1


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Basic Information Top
Gene Symbol:VRK1 ( MGC117401,MGC138280,MGC142070,PCH1 )
Gene Full Name: vaccinia related kinase 1
Band: 14q32.2
Quick LinksEntrez ID:7443; OMIM: 602168; Uniprot ID:VRK1_HUMAN; ENSEMBL ID: ENSG00000100749; HGNC ID: 12718
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant1 / 2362042
juvenile7 / 55556125
adult108 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma11 / 17475629
breast (mammary gland) tumor6 / 9417863
cervical tumor4 / 34366116
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor17 / 26384564
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia17 / 95842177
liver tumor7 / 9635972
lung tumor6 / 10312758
lymphoma9 / 71755125
non-neoplasia1 / 9725010
normal82 / 336030724
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer14 / 102680136
retinoblastoma5 / 46356107
skin tumor4 / 12494932
soft tissue/muscle tissue tumor49 / 125191391
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder11 / 29757369
blood11 / 12347889
bone7 / 7165597
bone marrow17 / 48801348
brain19 / 110098917
cervix6 / 48171124
connective tissue46 / 149255308
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye12 / 21105456
heart1 / 8962611
intestine4 / 23447217
kidney1 / 2117774
larynx0 / 241450 
liver9 / 20774343
lung10 / 33697429
lymph1 / 4427022
lymph node5 / 9161054
mammary gland7 / 15327145
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta6 / 28082521
prostate15 / 18934579
salivary gland6 / 20155297
skin6 / 21057428
spleen1 / 5395218
stomach3 / 9661931
testis23 / 33044269
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203856_at
Cell line Expression level Expression bar
721_B_lymphoblasts369.7
Adipocyte9.75
AdrenalCortex10.25
Adrenalgland7.35
Amygdala9.2
Appendix10.3
AtrioventricularNode9.2
BDCA4+_DentriticCells111.2
Bonemarrow9.65
BronchialEpithelialCells30.65
CD105+_Endothelial767.8
CD14+_Monocytes14.05
CD19+_BCells(neg._sel.)108.75
CD33+_Myeloid33.9
CD34+317.15
CD4+_Tcells35.85
CD56+_NKCells91.75
CD71+_EarlyErythroid562.7
CD8+_Tcells33.65
CardiacMyocytes13
Caudatenucleus7.85
Cerebellum6.8
CerebellumPeduncles10.25
CiliaryGanglion6.75
CingulateCortex9.1
Colorectaladenocarcinoma26.25
DorsalRootGanglion7.25
FetalThyroid8.5
Fetalbrain8.4
Fetalliver40.05
Fetallung6.95
GlobusPallidus6.75
Heart12.3
Hypothalamus8.85
Kidney7.5
Leukemia_chronicMyelogenousK-56288.95
Leukemia_promyelocytic-HL-60173.45
Leukemialymphoblastic(MOLT-4)209.45
Liver12.45
Lung8.85
Lymphnode9.2
Lymphoma_burkitts(Daudi)167.75
Lymphoma_burkitts(Raji)13.6
MedullaOblongata8.55
OccipitalLobe7.85
OlfactoryBulb6.85
Ovary6.4
Pancreas7.35
PancreaticIslet9.25
ParietalLobe9.35
Pituitary9.85
Placenta8.15
Pons8.35
PrefrontalCortex14.6
Prostate9.3
Salivarygland7.3
SkeletalMuscle11.15
Skin7.65
SmoothMuscle9.6
Spinalcord8.95
SubthalamicNucleus8.5
SuperiorCervicalGanglion10.85
TemporalLobe7.7
Testis7.5
TestisGermCell25.25
TestisIntersitial15.5
TestisLeydigCell12.2
TestisSeminiferousTubule15.55
Thalamus9.05
Thymus12.95
Thyroid10.45
Tongue8.85
Tonsil13.75
Trachea6.9
TrigeminalGanglion11.25
Uterus6.65
UterusCorpus8.85
WholeBlood14.9
Wholebrain7.25
colon16.45
pineal_day11
pineal_night17.16
retina10.35
small_intestine9.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12146_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.18 ± 0.32
Basal Forebrain6.34 ± 0.16
Basal Part of Pons6.13 ± 0.16
Cerebellar Cortex6.16 ± 0.22
Cerebellar Nuclei6.22 ± 0.3
Claustrum6.27 ± 0.48
Epithalamus6.18 ± 0.27
Frontal Lobe6.31 ± 0.31
Globus Pallidus6.03 ± 0.28
Hypothalamus6.21 ± 0.53
Insula6.31 ± 0.2
Limbic Lobe6.26 ± 0.35
Mesencephalon6.29 ± 0.39
Myelencephalon6.22 ± 0.34
Occipital Lobe6.09 ± 0.33
Parietal Lobe6.37 ± 0.3
Pontine Tegmentum6.37 ± 0.25
Striatum6.49 ± 0.39
Subthalamus6.75 ± 0.37
Temporal Lobe6.31 ± 0.27
Thalamus6.14 ± 0.33
White Matter5.97 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vrk1CBCerebellum0.42
0.67
Vrk1CTXCerebral cortex1.93
2.27
Vrk1HIPHippocampal region1
1.1
Vrk1HPFHippocampal formation1.11
1.23
Vrk1HYHypothalamus0.01
0
Vrk1LSXLateral septal complex0
0
Vrk1MBMidbrain0.15
0.23
Vrk1MYMedulla0.25
0.36
Vrk1OLFOlfactory bulb0.97
2.03
Vrk1PPons0.06
0.08
Vrk1PALPallidum0.13
0.1
Vrk1RHPRetrohippocampal region1.29
1.46
Vrk1sAMYStriatum-like amygdalar nuclei0.27
0.3
Vrk1STRStriatum7.04
4.45
Vrk1STRdStriatum dorsal region10.17
6.54
Vrk1STRvStriatum ventral region3.89
2.25
Vrk1THThalamus0.36
0.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001048 21 220 240 CHDGTIEFTSIDAHNGVAPSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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