AutismKB 2.0

Annotation Detail for VRK2


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Basic Information Top
Gene Symbol:VRK2 ( - )
Gene Full Name: vaccinia related kinase 2
Band: 2p16.1
Quick LinksEntrez ID:7444; OMIM: 602169; Uniprot ID:VRK2_HUMAN; ENSEMBL ID: ENSG00000028116; HGNC ID: 12719
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus23 / 56401240
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma7 / 7175597
non-neoplasia1 / 9725010
normal90 / 336030726
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer11 / 102680107
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow1 / 4880120
brain15 / 110098913
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine7 / 23447229
kidney1 / 2117774
larynx1 / 2414541
liver3 / 20774314
lung5 / 33697414
lymph2 / 4427045
lymph node6 / 9161065
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta10 / 28082535
prostate12 / 18934563
salivary gland0 / 201550 
skin10 / 21057447
spleen1 / 5395218
stomach2 / 9661920
testis14 / 33044242
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205126_at
Cell line Expression level Expression bar
721_B_lymphoblasts112.3
Adipocyte6.6
AdrenalCortex6.9
Adrenalgland4.95
Amygdala6.6
Appendix9.25
AtrioventricularNode5.1
BDCA4+_DentriticCells61.4
Bonemarrow5.6
BronchialEpithelialCells50.95
CD105+_Endothelial64.65
CD14+_Monocytes18.8
CD19+_BCells(neg._sel.)17.85
CD33+_Myeloid20.5
CD34+40.5
CD4+_Tcells7.25
CD56+_NKCells15
CD71+_EarlyErythroid35.75
CD8+_Tcells7.25
CardiacMyocytes8.45
Caudatenucleus5.9
Cerebellum4.4
CerebellumPeduncles7.45
CiliaryGanglion5.3
CingulateCortex5.85
Colorectaladenocarcinoma6.5
DorsalRootGanglion5
FetalThyroid10.25
Fetalbrain5.85
Fetalliver10.85
Fetallung7.65
GlobusPallidus4.85
Heart7.3
Hypothalamus9.9
Kidney5.3
Leukemia_chronicMyelogenousK-56252.7
Leukemia_promyelocytic-HL-6021.95
Leukemialymphoblastic(MOLT-4)5.35
Liver8.95
Lung6.4
Lymphnode8.9
Lymphoma_burkitts(Daudi)31.55
Lymphoma_burkitts(Raji)9.25
MedullaOblongata12.3
OccipitalLobe5.95
OlfactoryBulb6.25
Ovary4.65
Pancreas24.05
PancreaticIslet8
ParietalLobe6.95
Pituitary7.9
Placenta6.65
Pons6.3
PrefrontalCortex7.15
Prostate7.3
Salivarygland6.3
SkeletalMuscle7.9
Skin5.05
SmoothMuscle15.95
Spinalcord7.05
SubthalamicNucleus6
SuperiorCervicalGanglion8.75
TemporalLobe6.05
Testis10.2
TestisGermCell15.85
TestisIntersitial11.25
TestisLeydigCell12
TestisSeminiferousTubule14.55
Thalamus6.7
Thymus5.25
Thyroid8.5
Tongue7.65
Tonsil9.15
Trachea5.5
TrigeminalGanglion6.55
Uterus7.1
UterusCorpus8.05
WholeBlood14.3
Wholebrain5
colon6.65
pineal_day8.34
pineal_night7.72
retina8.15
small_intestine5.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10206_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.16 ± 0.86
Basal Forebrain5.61 ± 0.5
Basal Part of Pons5.08 ± 0.56
Cerebellar Cortex3.74 ± 0.52
Cerebellar Nuclei5.66 ± 0.71
Claustrum4.5 ± 0.92
Epithalamus4.81 ± 0.79
Frontal Lobe4.14 ± 1.07
Globus Pallidus6.7 ± 0.4
Hypothalamus4.02 ± 0.76
Insula3.72 ± 0.91
Limbic Lobe4.11 ± 0.98
Mesencephalon4.9 ± 0.97
Myelencephalon4.75 ± 0.73
Occipital Lobe5.44 ± 0.53
Parietal Lobe4.79 ± 0.69
Pontine Tegmentum4.62 ± 0.81
Striatum5.54 ± 0.59
Subthalamus5.19 ± 0.05
Temporal Lobe4.54 ± 0.83
Thalamus5.07 ± 0.64
White Matter7.94 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vrk2CBCerebellum1.28
2.49
Vrk2CTXCerebral cortex2.27
1.94
Vrk2HIPHippocampal region7.22
8
Vrk2HPFHippocampal formation6.67
6.71
Vrk2HYHypothalamus0.81
0.85
Vrk2LSXLateral septal complex0.56
0.35
Vrk2MBMidbrain0.66
1.18
Vrk2MYMedulla1.47
2.65
Vrk2OLFOlfactory bulb3.4
3.32
Vrk2PPons1.54
3.22
Vrk2PALPallidum2.56
3.11
Vrk2RHPRetrohippocampal region4.17
2.84
Vrk2sAMYStriatum-like amygdalar nuclei3.61
4.18
Vrk2STRStriatum1.95
2.22
Vrk2STRdStriatum dorsal region0.43
0.38
Vrk2STRvStriatum ventral region5.8
6.69
Vrk2THThalamus1.52
1.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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