AutismKB 2.0

Annotation Detail for WRN


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Basic Information Top
Gene Symbol:WRN ( DKFZp686C2056,RECQ3,RECQL2,RECQL3 )
Gene Full Name: Werner syndrome, RecQ helicase-like
Band: 8p12
Quick LinksEntrez ID:7486; OMIM: 604611; Uniprot ID:WRN_HUMAN; ENSEMBL ID: ENSG00000165392; HGNC ID: 12791
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal39 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow1 / 4880120
brain7 / 11009896
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx3 / 24145124
liver4 / 20774319
lung3 / 3369748
lymph0 / 442700 
lymph node4 / 9161043
mammary gland3 / 15327119
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205667_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.3
Adipocyte7.7
AdrenalCortex13.9
Adrenalgland7.45
Amygdala7.45
Appendix19.95
AtrioventricularNode15.9
BDCA4+_DentriticCells8.6
Bonemarrow9.6
BronchialEpithelialCells7.75
CD105+_Endothelial150.9
CD14+_Monocytes8.6
CD19+_BCells(neg._sel.)8.3
CD33+_Myeloid11.05
CD34+68.95
CD4+_Tcells8.9
CD56+_NKCells8.9
CD71+_EarlyErythroid113.5
CD8+_Tcells10.9
CardiacMyocytes19.85
Caudatenucleus6.9
Cerebellum6.35
CerebellumPeduncles9.55
CiliaryGanglion8.15
CingulateCortex8.35
Colorectaladenocarcinoma9.45
DorsalRootGanglion8.6
FetalThyroid8.25
Fetalbrain7.5
Fetalliver7.35
Fetallung6.8
GlobusPallidus6.3
Heart19.3
Hypothalamus8.85
Kidney7
Leukemia_chronicMyelogenousK-56239.3
Leukemia_promyelocytic-HL-607.4
Leukemialymphoblastic(MOLT-4)23.75
Liver14.2
Lung8.55
Lymphnode7.05
Lymphoma_burkitts(Daudi)19.6
Lymphoma_burkitts(Raji)15.45
MedullaOblongata7.2
OccipitalLobe6.65
OlfactoryBulb6.4
Ovary6.05
Pancreas7.1
PancreaticIslet9.5
ParietalLobe9.45
Pituitary9.3
Placenta7.65
Pons8
PrefrontalCortex9.85
Prostate9.6
Salivarygland7.35
SkeletalMuscle15.8
Skin9.8
SmoothMuscle11.85
Spinalcord8.85
SubthalamicNucleus7.6
SuperiorCervicalGanglion15.45
TemporalLobe7.75
Testis7.1
TestisGermCell6.55
TestisIntersitial7.2
TestisLeydigCell8.6
TestisSeminiferousTubule7.1
Thalamus7.95
Thymus5.45
Thyroid10.15
Tongue10.35
Tonsil7.7
Trachea6.3
TrigeminalGanglion15.6
Uterus6.75
UterusCorpus13.2
WholeBlood8.95
Wholebrain6.05
colon8.65
pineal_day9.72
pineal_night9.24
retina9.475
small_intestine8.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4632_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.72 ± 0.44
Basal Forebrain4.64 ± 0.29
Basal Part of Pons4.37 ± 0.67
Cerebellar Cortex4.54 ± 0.36
Cerebellar Nuclei4.4 ± 0.34
Claustrum4.38 ± 0.59
Epithalamus5.09 ± 0.41
Frontal Lobe4.28 ± 0.48
Globus Pallidus4.89 ± 0.44
Hypothalamus4.15 ± 0.44
Insula4.35 ± 0.32
Limbic Lobe4.47 ± 0.46
Mesencephalon4.46 ± 0.4
Myelencephalon4.41 ± 0.56
Occipital Lobe4.65 ± 0.44
Parietal Lobe4.33 ± 0.53
Pontine Tegmentum4.45 ± 0.51
Striatum4.63 ± 0.46
Subthalamus4.47 ± 0.56
Temporal Lobe4.34 ± 0.53
Thalamus4.32 ± 0.52
White Matter5.32 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
WrnCBCerebellum3.63
5.36
WrnCTXCerebral cortex2.7
2.05
WrnHIPHippocampal region2.53
2.21
WrnHPFHippocampal formation1.97
1.6
WrnHYHypothalamus0.78
0.87
WrnLSXLateral septal complex0.25
0.23
WrnMBMidbrain1.59
2.08
WrnMYMedulla2.28
2.36
WrnOLFOlfactory bulb3.63
2.37
WrnPPons1.58
1.82
WrnPALPallidum0.75
0.97
WrnRHPRetrohippocampal region1.1
0.82
WrnsAMYStriatum-like amygdalar nuclei2.24
1.93
WrnSTRStriatum1.86
2.2
WrnSTRdStriatum dorsal region2.1
2.85
WrnSTRvStriatum ventral region1.32
0.94
WrnTHThalamus3.62
5.1
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00433080 23 1221 1243 HFCQTNSVQTDLFSSTKPQEEQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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