AutismKB 2.0

Annotation Detail for XPO1


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Basic Information Top
Gene Symbol:XPO1 ( CRM1,DKFZp686B1823,emb )
Gene Full Name: exportin 1 (CRM1 homolog, yeast)
Band: 2p15
Quick LinksEntrez ID:7514; OMIM: 602559; Uniprot ID:XPO1_HUMAN; ENSEMBL ID: ENSG00000082898; HGNC ID: 12825
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body28 / 70761395
blastocyst21 / 62319336
fetus59 / 564012104
neonate3 / 3109796
infant2 / 2362084
juvenile10 / 55556179
adult250 / 1939121128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor17 / 94178180
cervical tumor5 / 34366145
chondrosarcoma9 / 82823108
colorectal tumor11 / 11424696
esophageal tumor7 / 17290404
gastrointestinal tumor25 / 119369209
germ cell tumor71 / 263845269
glioma9 / 10688384
head and neck tumor22 / 136302161
kidney tumor9 / 68959130
leukemia7 / 9584273
liver tumor15 / 96359155
lung tumor4 / 10312738
lymphoma3 / 7175541
non-neoplasia6 / 9725061
normal402 / 3360307119
ovarian tumor12 / 76682156
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer11 / 102680107
retinoblastoma13 / 46356280
skin tumor20 / 124949160
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor22 / 90257243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites7 / 40015174
bladder6 / 29757201
blood7 / 12347856
bone7 / 7165597
bone marrow5 / 48801102
brain115 / 1100989104
cervix7 / 48171145
connective tissue8 / 14925553
ear2 / 16212123
embryonic tissue75 / 215722347
esophagus8 / 20209395
eye25 / 211054118
heart5 / 8962655
intestine29 / 234472123
kidney24 / 211777113
larynx2 / 2414582
liver31 / 207743149
lung33 / 33697497
lymph2 / 4427045
lymph node18 / 91610196
mammary gland18 / 153271117
mouth18 / 67052268
muscle29 / 107715269
nerve3 / 15768190
ovary10 / 10205197
pancreas15 / 21481269
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta37 / 280825131
prostate18 / 18934595
salivary gland0 / 201550 
skin22 / 210574104
spleen8 / 53952148
stomach15 / 96619155
testis87 / 330442263
thymus22 / 81131271
thyroid5 / 47473105
tonsil1 / 1699958
trachea19 / 52413362
umbilical cord0 / 136800 
uterus59 / 232878253
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208775_at
Cell line Expression level Expression bar
721_B_lymphoblasts974.75
Adipocyte107.55
AdrenalCortex49.15
Adrenalgland51.1
Amygdala197.35
Appendix78.65
AtrioventricularNode49.5
BDCA4+_DentriticCells434.9
Bonemarrow43.85
BronchialEpithelialCells208
CD105+_Endothelial576.6
CD14+_Monocytes269.5
CD19+_BCells(neg._sel.)428.9
CD33+_Myeloid513.05
CD34+909.7
CD4+_Tcells510.5
CD56+_NKCells465.3
CD71+_EarlyErythroid305.75
CD8+_Tcells555
CardiacMyocytes159.4
Caudatenucleus110.95
Cerebellum46.55
CerebellumPeduncles111.55
CiliaryGanglion24.2
CingulateCortex109
Colorectaladenocarcinoma379.1
DorsalRootGanglion50.5
FetalThyroid142.7
Fetalbrain391.8
Fetalliver124.5
Fetallung201.75
GlobusPallidus54.45
Heart12.35
Hypothalamus239.1
Kidney22.25
Leukemia_chronicMyelogenousK-562317.35
Leukemia_promyelocytic-HL-60419.25
Leukemialymphoblastic(MOLT-4)413.45
Liver11.65
Lung42.35
Lymphnode228.05
Lymphoma_burkitts(Daudi)562.4
Lymphoma_burkitts(Raji)306.6
MedullaOblongata139.85
OccipitalLobe128.1
OlfactoryBulb177.9
Ovary94.8
Pancreas112.9
PancreaticIslet83.35
ParietalLobe88.75
Pituitary205.2
Placenta100.6
Pons59.45
PrefrontalCortex475.9
Prostate151.75
Salivarygland103.95
SkeletalMuscle35.6
Skin47.45
SmoothMuscle206.2
Spinalcord175.45
SubthalamicNucleus59.95
SuperiorCervicalGanglion32.35
TemporalLobe91.7
Testis91.8
TestisGermCell401
TestisIntersitial150.9
TestisLeydigCell121.3
TestisSeminiferousTubule143.3
Thalamus137.3
Thymus175.45
Thyroid237.05
Tongue78.75
Tonsil184.5
Trachea80.35
TrigeminalGanglion82.55
Uterus316.85
UterusCorpus21.9
WholeBlood232.7
Wholebrain120.8
colon276.05
pineal_day759.66
pineal_night782.18
retina183.9
small_intestine163.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P40078
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.35 ± 0.33
Basal Forebrain7.41 ± 0.09
Basal Part of Pons7.27 ± 0.19
Cerebellar Cortex7.31 ± 0.26
Cerebellar Nuclei7.35 ± 0.21
Claustrum7.54 ± 0.34
Epithalamus7.64 ± 0.17
Frontal Lobe7.3 ± 0.24
Globus Pallidus7.61 ± 0.26
Hypothalamus7.53 ± 0.14
Insula7.33 ± 0.3
Limbic Lobe7.33 ± 0.26
Mesencephalon7.34 ± 0.26
Myelencephalon7.32 ± 0.28
Occipital Lobe7.41 ± 0.25
Parietal Lobe7.32 ± 0.26
Pontine Tegmentum7.34 ± 0.28
Striatum7.24 ± 0.21
Subthalamus7.22 ± 0.31
Temporal Lobe7.35 ± 0.25
Thalamus7.32 ± 0.26
White Matter7.93 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Xpo1CBCerebellum0.99
1.04
Xpo1CTXCerebral cortex14.04
10.22
Xpo1HIPHippocampal region19.64
23.46
Xpo1HPFHippocampal formation14.4
15.92
Xpo1HYHypothalamus25.14
19.84
Xpo1LSXLateral septal complex34.32
25.67
Xpo1MBMidbrain1.99
2.44
Xpo1MYMedulla0.13
0.21
Xpo1OLFOlfactory bulb15.74
12.49
Xpo1PPons0.43
0.61
Xpo1PALPallidum27.41
21.34
Xpo1RHPRetrohippocampal region3.1
2.93
Xpo1sAMYStriatum-like amygdalar nuclei40.09
27.99
Xpo1STRStriatum13.71
10.2
Xpo1STRdStriatum dorsal region5.11
4.5
Xpo1STRvStriatum ventral region15.28
9.86
Xpo1THThalamus17.4
14.66
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002249 16 458 473 ETLVYLTHLDYVDTER Peptide Atlas
XPO1_HUMAN_2 13 2 14 PAIMTMLADHAAR PRIDE
XPO1_HUMAN_296 10 296 305 QMLPLNTNIR PRIDE
XPO1_HUMAN_515 16 515 530 FLVTVIKDLLGLCEQK PRIDE
XPO1_HUMAN_6 9 6 14 TMLADHAAR PRIDE
XPO1_HUMAN_7 8 7 14 MLADHAAR PRIDE
XPO1_HUMAN_712 10 712 721 IYLDMLNVYK PRIDE
XPO1_HUMAN_76 12 76 87 YYGLQILENVIK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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