AutismKB 2.0

Annotation Detail for YWHAE


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Basic Information Top
Gene Symbol:YWHAE ( 14-3-3E,FLJ45465,FLJ53559,KCIP-1,MDCR,MDS )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Band: 17p13.3
Quick LinksEntrez ID:7531; OMIM: 605066; Uniprot ID:1433E_HUMAN; ENSEMBL ID: ENSG00000108953; HGNC ID: 12851
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body34 / 70761480
blastocyst33 / 62319529
fetus200 / 564012354
neonate8 / 31097257
infant52 / 236202201
juvenile49 / 55556881
adult652 / 1939121336
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma1 / 1747557
breast (mammary gland) tumor45 / 94178477
cervical tumor22 / 34366640
chondrosarcoma46 / 82823555
colorectal tumor38 / 114246332
esophageal tumor18 / 172901041
gastrointestinal tumor78 / 119369653
germ cell tumor115 / 263845435
glioma33 / 106883308
head and neck tumor46 / 136302337
kidney tumor23 / 68959333
leukemia29 / 95842302
liver tumor64 / 96359664
lung tumor36 / 103127349
lymphoma26 / 71755362
non-neoplasia71 / 97250730
normal1318 / 3360307392
ovarian tumor35 / 76682456
pancreatic tumor33 / 104616315
primitive neuroectodermal tumor of the CNS98 / 125680779
prostate cancer29 / 102680282
retinoblastoma43 / 46356927
skin tumor30 / 124949240
soft tissue/muscle tissue tumor60 / 125191479
uterine tumor30 / 90257332
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland14 / 33197421
ascites32 / 40015799
bladder12 / 29757403
blood38 / 123478307
bone38 / 71655530
bone marrow16 / 48801327
brain653 / 1100989593
cervix31 / 48171643
connective tissue32 / 149255214
ear3 / 16212185
embryonic tissue101 / 215722468
esophagus20 / 20209989
eye87 / 211054412
heart81 / 89626903
intestine90 / 234472383
kidney88 / 211777415
larynx2 / 2414582
liver113 / 207743543
lung133 / 336974394
lymph7 / 44270158
lymph node16 / 91610174
mammary gland65 / 153271424
mouth30 / 67052447
muscle39 / 107715362
nerve8 / 15768507
ovary43 / 102051421
pancreas47 / 214812218
parathyroid12 / 20539584
pharynx5 / 41328120
pituitary gland2 / 16585120
placenta81 / 280825288
prostate42 / 189345221
salivary gland5 / 20155248
skin67 / 210574318
spleen6 / 53952111
stomach48 / 96619496
testis148 / 330442447
thymus8 / 8113198
thyroid18 / 47473379
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord5 / 13680365
uterus125 / 232878536
vascular61 / 517801178
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210317_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts310.25
Adipocyte136.95
AdrenalCortex17.3
Adrenalgland28.4
Amygdala151.3
Appendix11.05
AtrioventricularNode14.15
BDCA4+_DentriticCells30.85
Bonemarrow17.9
BronchialEpithelialCells205.9
CD105+_Endothelial15.4
CD14+_Monocytes32.4
CD19+_BCells(neg._sel.)10.4
CD33+_Myeloid26.5
CD34+31.1
CD4+_Tcells11.95
CD56+_NKCells9.65
CD71+_EarlyErythroid28.55
CD8+_Tcells10.05
CardiacMyocytes86.7
Caudatenucleus92.55
Cerebellum153.4
CerebellumPeduncles61.9
CiliaryGanglion21.55
CingulateCortex94.45
Colorectaladenocarcinoma229.7
DorsalRootGanglion19.55
FetalThyroid21.55
Fetalbrain71.75
Fetalliver36.85
Fetallung41.7
GlobusPallidus40.65
Heart31.6
Hypothalamus45.6
Kidney29.2
Leukemia_chronicMyelogenousK-56236.65
Leukemia_promyelocytic-HL-6032.75
Leukemialymphoblastic(MOLT-4)85.5
Liver26
Lung17.75
Lymphnode9.3
Lymphoma_burkitts(Daudi)39.25
Lymphoma_burkitts(Raji)17.95
MedullaOblongata139.6
OccipitalLobe124.9
OlfactoryBulb26.65
Ovary53.45
Pancreas8.1
PancreaticIslet43.55
ParietalLobe69.2
Pituitary63.6
Placenta137.95
Pons65.4
PrefrontalCortex308.9
Prostate12.1
Salivarygland18.2
SkeletalMuscle19.2
Skin13.15
SmoothMuscle110.85
Spinalcord60.7
SubthalamicNucleus75
SuperiorCervicalGanglion24.05
TemporalLobe76.5
Testis23.6
TestisGermCell102.15
TestisIntersitial65.65
TestisLeydigCell48.75
TestisSeminiferousTubule42.35
Thalamus59.15
Thymus23.9
Thyroid30.6
Tongue24.15
Tonsil33.55
Trachea51.5
TrigeminalGanglion18.95
Uterus12.85
UterusCorpus26.2
WholeBlood28.15
Wholebrain118.8
colon139.3
pineal_day136.94
pineal_night177.9
retina292.55
small_intestine76.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P123011
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.29 ± 0.3
Basal Forebrain10.76 ± 0.19
Basal Part of Pons10.78 ± 0.27
Cerebellar Cortex10.57 ± 0.26
Cerebellar Nuclei10.73 ± 0.2
Claustrum11.27 ± 0.5
Epithalamus10.52 ± 0.31
Frontal Lobe10.75 ± 0.34
Globus Pallidus11.16 ± 0.15
Hypothalamus10.58 ± 0.31
Insula10.82 ± 0.28
Limbic Lobe11.1 ± 0.32
Mesencephalon10.86 ± 0.28
Myelencephalon10.83 ± 0.32
Occipital Lobe11 ± 0.3
Parietal Lobe10.86 ± 0.35
Pontine Tegmentum10.83 ± 0.26
Striatum10.92 ± 0.3
Subthalamus10.63 ± 0.05
Temporal Lobe10.82 ± 0.3
Thalamus10.79 ± 0.29
White Matter11.34 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
YwhaeCBCerebellum75.68
62.61
YwhaeCTXCerebral cortex99.57
89.24
YwhaeHIPHippocampal region90.67
100
YwhaeHPFHippocampal formation93.55
97.26
YwhaeHYHypothalamus78.46
72.22
YwhaeLSXLateral septal complex72.53
49.93
YwhaeMBMidbrain91.17
85.51
YwhaeMYMedulla84.83
84.57
YwhaeOLFOlfactory bulb100
95.75
YwhaePPons81.57
81.04
YwhaePALPallidum63.26
57.8
YwhaeRHPRetrohippocampal region99.23
88.83
YwhaesAMYStriatum-like amygdalar nuclei73.59
65.75
YwhaeSTRStriatum78.71
58.64
YwhaeSTRdStriatum dorsal region73.72
53.45
YwhaeSTRvStriatum ventral region93.12
66.14
YwhaeTHThalamus87
84.08
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
1433E_HUMAN_0 0 0 0 AASDIAMTELPPTHPIR PRIDE
1433E_HUMAN_0 0 0 0 DSTLIMQLLR PRIDE
1433E_HUMAN_0 0 0 0 EAAENSLVAYK PRIDE
1433E_HUMAN_0 0 0 0 EALQDVEDENQ PRIDE
1433E_HUMAN_0 0 0 0 LICCDILDVLDK PRIDE
1433E_HUMAN_0 0 0 0 YLAEFATGNDR PRIDE
1433E_HUMAN_0 0 0 0 YLAEFATGNDRK PRIDE
1433E_HUMAN_1 12 1 12 MDDREDLVYQAK PRIDE
1433E_HUMAN_1 19 1 19 MDDREDLVYQAKLAEQAER PRIDE
1433E_HUMAN_106 12 106 117 HLIPAANTGESK PRIDE
1433E_HUMAN_107 12 107 118 HLIPAANTGESK PRIDE
1433E_HUMAN_119 5 119 123 VFYYK PRIDE
1433E_HUMAN_12 16 12 27 LAEQAERYDEMVESMK PRIDE
1433E_HUMAN_12 17 12 28 LAEQAERYDEMVESMKK PRIDE
1433E_HUMAN_130 11 130 140 YLAEFATGNDR PRIDE
1433E_HUMAN_130 12 130 141 YLAEFATGNDRK PRIDE
1433E_HUMAN_131 11 131 141 YLAEFATGNDR PRIDE
1433E_HUMAN_131 12 131 142 YLAEFATGNDRK PRIDE
1433E_HUMAN_141 12 141 152 KEAAENSLVAYK PRIDE
1433E_HUMAN_142 11 142 152 EAAENSLVAYK PRIDE
1433E_HUMAN_143 11 143 153 EAAENSLVAYK PRIDE
1433E_HUMAN_153 17 153 169 AASDIAMTELPPTHPIR PRIDE
1433E_HUMAN_154 17 154 170 AASDIAMTELPPTHPIR PRIDE
1433E_HUMAN_171 20 171 190 LGLALNFSVFYYEILNSPDR PRIDE
1433E_HUMAN_196 19 196 214 AAFDDAIAELDTLSEESYK PRIDE
1433E_HUMAN_196 29 196 224 AAFDDAIAELDTLSEESYKDSTLIMQLLR PRIDE
1433E_HUMAN_197 19 197 215 AAFDDAIAELDTLSEESYK PRIDE
1433E_HUMAN_215 10 215 224 DSTLIMQLLR PRIDE
1433E_HUMAN_216 10 216 225 DSTLIMQLLR PRIDE
1433E_HUMAN_244 11 244 254 EALQDVEDENQ PRIDE
1433E_HUMAN_28 14 28 41 KVAGMDVELTVEER PRIDE
1433E_HUMAN_29 13 29 41 VAGMDVELTVEER PRIDE
1433E_HUMAN_29 14 29 42 KVAGMDVELTVEER PRIDE
1433E_HUMAN_30 13 30 42 VAGMDVELTVEER PRIDE
1433E_HUMAN_42 14 42 55 NLLSVAYKNVIGAR PRIDE
1433E_HUMAN_42 8 42 49 NLLSVAYK PRIDE
1433E_HUMAN_43 8 43 50 NLLSVAYK PRIDE
1433E_HUMAN_62 12 62 73 IISSIEQKEENK PRIDE
1433E_HUMAN_83 11 83 93 EYRQMVETELK PRIDE
1433E_HUMAN_87 8 87 94 QMVETELK PRIDE
1433E_HUMAN_94 12 94 105 LICCDILDVLDK PRIDE
1433E_HUMAN_94 24 94 117 LICCDILDVLDKHLIPAANTGESK PRIDE
1433E_HUMAN_94 29 94 122 LICCDILDVLDKHLIPAANTGESKVFYYK PRIDE
1433E_HUMAN_95 12 95 106 LICCDILDVLDK PRIDE
1433E_HUMAN_95 24 95 118 LICCDILDVLDKHLIPAANTGESK PRIDE
PAp00004995 12 95 106 LICCDILDVLDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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