AutismKB 2.0

Annotation Detail for YWHAZ


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Basic Information Top
Gene Symbol:YWHAZ ( 14-3-3-zeta,KCIP-1,MGC111427,MGC126532,MGC138156,YWHAD )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Band: 8q22.3
Quick LinksEntrez ID:7534; OMIM: 601288; Uniprot ID:1433Z_HUMAN; ENSEMBL ID: ENSG00000164924; HGNC ID: 12855
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body67 / 70761946
blastocyst34 / 62319545
fetus134 / 564012237
neonate4 / 31097128
infant4 / 23620169
juvenile16 / 55556287
adult419 / 1939121216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma15 / 17475858
breast (mammary gland) tumor25 / 94178265
cervical tumor21 / 34366611
chondrosarcoma15 / 82823181
colorectal tumor66 / 114246577
esophageal tumor8 / 17290462
gastrointestinal tumor48 / 119369402
germ cell tumor90 / 263845341
glioma17 / 106883159
head and neck tumor37 / 136302271
kidney tumor21 / 68959304
leukemia42 / 95842438
liver tumor22 / 96359228
lung tumor24 / 103127232
lymphoma33 / 71755459
non-neoplasia11 / 97250113
normal747 / 3360307222
ovarian tumor32 / 76682417
pancreatic tumor25 / 104616238
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer19 / 102680185
retinoblastoma49 / 463561057
skin tumor49 / 124949392
soft tissue/muscle tissue tumor37 / 125191295
uterine tumor33 / 90257365
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue12 / 13106915
adrenal gland8 / 33197240
ascites22 / 40015549
bladder14 / 29757470
blood44 / 123478356
bone16 / 71655223
bone marrow20 / 48801409
brain308 / 1100989279
cervix23 / 48171477
connective tissue13 / 14925587
ear6 / 16212370
embryonic tissue150 / 215722695
esophagus9 / 20209445
eye72 / 211054341
heart17 / 89626189
intestine94 / 234472400
kidney35 / 211777165
larynx4 / 24145165
liver43 / 207743206
lung54 / 336974160
lymph12 / 44270271
lymph node29 / 91610316
mammary gland40 / 153271260
mouth30 / 67052447
muscle3 / 10771527
nerve6 / 15768380
ovary28 / 102051274
pancreas40 / 214812186
parathyroid7 / 20539340
pharynx4 / 4132896
pituitary gland3 / 16585180
placenta59 / 280825210
prostate31 / 189345163
salivary gland4 / 20155198
skin72 / 210574341
spleen6 / 53952111
stomach28 / 96619289
testis77 / 330442233
thymus8 / 8113198
thyroid3 / 4747363
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord0 / 136800 
uterus85 / 232878364
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200640_at
Cell line Expression level Expression bar
721_B_lymphoblasts1752.1
Adipocyte618.6
AdrenalCortex504.85
Adrenalgland337.65
Amygdala1153
Appendix203.55
AtrioventricularNode149
BDCA4+_DentriticCells1598.2
Bonemarrow520.95
BronchialEpithelialCells2340.45
CD105+_Endothelial248.3
CD14+_Monocytes1188.3
CD19+_BCells(neg._sel.)1981.3
CD33+_Myeloid1239.9
CD34+909.1
CD4+_Tcells1922.7
CD56+_NKCells2455.2
CD71+_EarlyErythroid76.85
CD8+_Tcells1588.1
CardiacMyocytes1133.55
Caudatenucleus905.75
Cerebellum507.4
CerebellumPeduncles824.7
CiliaryGanglion159.65
CingulateCortex1139.2
Colorectaladenocarcinoma330.25
DorsalRootGanglion298.1
FetalThyroid554.25
Fetalbrain1830.2
Fetalliver312.85
Fetallung682.9
GlobusPallidus685.3
Heart20.65
Hypothalamus1365.15
Kidney172.9
Leukemia_chronicMyelogenousK-562732.05
Leukemia_promyelocytic-HL-60692
Leukemialymphoblastic(MOLT-4)1017.05
Liver13
Lung64.4
Lymphnode580.15
Lymphoma_burkitts(Daudi)1440.5
Lymphoma_burkitts(Raji)449.55
MedullaOblongata1166.85
OccipitalLobe1667.95
OlfactoryBulb658.85
Ovary274.05
Pancreas913.5
PancreaticIslet779.65
ParietalLobe1154.4
Pituitary495.35
Placenta1269.1
Pons804.45
PrefrontalCortex1242.2
Prostate198.1
Salivarygland382.75
SkeletalMuscle45.9
Skin282.85
SmoothMuscle1417.3
Spinalcord540.05
SubthalamicNucleus795.35
SuperiorCervicalGanglion181.3
TemporalLobe949.2
Testis118
TestisGermCell486.1
TestisIntersitial169.95
TestisLeydigCell137.3
TestisSeminiferousTubule239.35
Thalamus1332.7
Thymus641.45
Thyroid395.25
Tongue788.9
Tonsil1305.4
Trachea672.1
TrigeminalGanglion188.5
Uterus278.55
UterusCorpus202.9
WholeBlood1571.95
Wholebrain663.45
colon1073.9
pineal_day1513.24
pineal_night1463.72
retina765.9
small_intestine1118.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P209571
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.99 ± 0.44
Basal Forebrain10.61 ± 0.3
Basal Part of Pons10.98 ± 0.2
Cerebellar Cortex10.61 ± 0.17
Cerebellar Nuclei10.45 ± 0.38
Claustrum10.99 ± 0.3
Epithalamus10.19 ± 0.46
Frontal Lobe10.79 ± 0.3
Globus Pallidus9.56 ± 0.38
Hypothalamus10.67 ± 0.27
Insula10.83 ± 0.15
Limbic Lobe10.94 ± 0.49
Mesencephalon10.48 ± 0.39
Myelencephalon10.65 ± 0.45
Occipital Lobe10.46 ± 0.5
Parietal Lobe10.65 ± 0.36
Pontine Tegmentum10.64 ± 0.37
Striatum10.71 ± 0.46
Subthalamus10.46 ± 0.28
Temporal Lobe10.89 ± 0.36
Thalamus10.73 ± 0.32
White Matter9.38 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
YwhazCBCerebellum85.98
100
YwhazCTXCerebral cortex100
100
YwhazHIPHippocampal region100
100
YwhazHPFHippocampal formation100
100
YwhazHYHypothalamus96.94
100
YwhazLSXLateral septal complex100
100
YwhazMBMidbrain96.03
100
YwhazMYMedulla97.28
100
YwhazOLFOlfactory bulb100
100
YwhazPPons96.28
100
YwhazPALPallidum94.57
100
YwhazRHPRetrohippocampal region100
100
YwhazsAMYStriatum-like amygdalar nuclei94.49
100
YwhazSTRStriatum100
100
YwhazSTRdStriatum dorsal region100
100
YwhazSTRvStriatum ventral region100
100
YwhazTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
1433Z_HUMAN_0 0 0 0 DICNDVLSLLEK PRIDE
1433Z_HUMAN_0 0 0 0 DSTLIMQLLR PRIDE
1433Z_HUMAN_0 0 0 0 EKIETELR PRIDE
1433Z_HUMAN_0 0 0 0 GIVDQSQQAYQEAFEISKK PRIDE
1433Z_HUMAN_0 0 0 0 SVTEQGAELSNEER PRIDE
1433Z_HUMAN_0 0 0 0 TAFDEAIAELDTLSEESYK PRIDE
1433Z_HUMAN_0 0 0 0 YDDMAACMK PRIDE
1433Z_HUMAN_0 0 0 0 YLAEVAAGDDK PRIDE
1433Z_HUMAN_0 0 0 0 YLAEVAAGDDKK PRIDE
1433Z_HUMAN_1 11 1 11 MDKNELVQKAK PRIDE
1433Z_HUMAN_1 18 1 18 MDKNELVQKAKLAEQAER PRIDE
1433Z_HUMAN_1 9 1 9 MDKNELVQK PRIDE
1433Z_HUMAN_103 12 103 114 FLIPNASQAESK PRIDE
1433Z_HUMAN_104 12 104 115 FLIPNASQAESK PRIDE
1433Z_HUMAN_11 16 11 26 LAEQAERYDDMAACMK PRIDE
1433Z_HUMAN_116 5 116 120 VFYLK PRIDE
1433Z_HUMAN_120 7 120 126 MKGDYYR PRIDE
1433Z_HUMAN_127 11 127 137 YLAEVAAGDDK PRIDE
1433Z_HUMAN_127 12 127 138 YLAEVAAGDDKK PRIDE
1433Z_HUMAN_128 12 128 139 YLAEVAAGDDKK PRIDE
1433Z_HUMAN_138 20 138 157 KGIVDQSQQAYQEAFEISKK PRIDE
1433Z_HUMAN_139 18 139 156 GIVDQSQQAYQEAFEISK PRIDE
1433Z_HUMAN_139 19 139 157 GIVDQSQQAYQEAFEISKK PRIDE
1433Z_HUMAN_140 18 140 157 GIVDQSQQAYQEAFEISK PRIDE
1433Z_HUMAN_158 9 158 166 EMQPTHPIR PRIDE
1433Z_HUMAN_18 9 18 26 YDDMAACMK PRIDE
1433Z_HUMAN_193 19 193 211 TAFDEAIAELDTLSEESYK PRIDE
1433Z_HUMAN_194 19 194 212 TAFDEAIAELDTLSEESYK PRIDE
1433Z_HUMAN_2 17 2 18 DKNELVQKAKLAEQAER PRIDE
1433Z_HUMAN_212 10 212 221 DSTLIMQLLR PRIDE
1433Z_HUMAN_213 10 213 222 DSTLIMQLLR PRIDE
1433Z_HUMAN_27 14 27 40 SVTEQGAELSNEER PRIDE
1433Z_HUMAN_27 22 27 48 SVTEQGAELSNEERNLLSVAYK PRIDE
1433Z_HUMAN_28 14 28 41 SVTEQGAELSNEER PRIDE
1433Z_HUMAN_41 14 41 54 NLLSVAYKNVVGAR PRIDE
1433Z_HUMAN_41 8 41 48 NLLSVAYK PRIDE
1433Z_HUMAN_42 8 42 49 NLLSVAYK PRIDE
1433Z_HUMAN_60 14 60 73 VVSSIEQKTEGAEK PRIDE
1433Z_HUMAN_60 15 60 74 VVSSIEQKTEGAEKK PRIDE
1433Z_HUMAN_80 11 80 90 EYREKIETELR PRIDE
1433Z_HUMAN_83 20 83 102 EKIETELRDICNDVLSLLEK PRIDE
1433Z_HUMAN_83 8 83 90 EKIETELR PRIDE
1433Z_HUMAN_84 8 84 91 EKIETELR PRIDE
1433Z_HUMAN_85 18 85 102 IETELRDICNDVLSLLEK PRIDE
1433Z_HUMAN_9 18 9 26 AKLAEQAERYDDMAACMK PRIDE
1433Z_HUMAN_91 12 91 102 DICNDVLSLLEK PRIDE
1433Z_HUMAN_91 24 91 114 DICNDVLSLLEKFLIPNASQAESK PRIDE
1433Z_HUMAN_92 12 92 103 DICNDVLSLLEK PRIDE
1433Z_HUMAN_92 24 92 115 DICNDVLSLLEKFLIPNASQAESK PRIDE
PAp00000474 18 10 27 AKLAEQAERYDDMAACMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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