AutismKB 2.0

Annotation Detail for ZAP70


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Basic Information Top
Gene Symbol:ZAP70 ( FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70 )
Gene Full Name: zeta-chain (TCR) associated protein kinase 70kDa
Band: 2q11.2
Quick LinksEntrez ID:7535; OMIM: 176947; Uniprot ID:ZAP70_HUMAN; ENSEMBL ID: ENSG00000115085; HGNC ID: 12858
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult33 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia13 / 95842135
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal48 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood15 / 123478121
bone0 / 716550 
bone marrow2 / 4880140
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver3 / 20774314
lung0 / 3369740 
lymph0 / 442700 
lymph node7 / 9161076
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis0 / 3304420 
thymus30 / 81131369
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214032_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.9
Adipocyte4.75
AdrenalCortex5.15
Adrenalgland4.05
Amygdala4.9
Appendix4.75
AtrioventricularNode3.8
BDCA4+_DentriticCells6.2
Bonemarrow4.85
BronchialEpithelialCells4.6
CD105+_Endothelial4.8
CD14+_Monocytes5.1
CD19+_BCells(neg._sel.)4.95
CD33+_Myeloid6.15
CD34+6.1
CD4+_Tcells580.8
CD56+_NKCells906.7
CD71+_EarlyErythroid4.45
CD8+_Tcells511.25
CardiacMyocytes6
Caudatenucleus4.25
Cerebellum3.85
CerebellumPeduncles5.4
CiliaryGanglion3.55
CingulateCortex4.9
Colorectaladenocarcinoma5.6
DorsalRootGanglion3.7
FetalThyroid4.55
Fetalbrain4.7
Fetalliver4.15
Fetallung3.9
GlobusPallidus3.5
Heart6.2
Hypothalamus5.15
Kidney3.9
Leukemia_chronicMyelogenousK-5624.25
Leukemia_promyelocytic-HL-604.2
Leukemialymphoblastic(MOLT-4)288.7
Liver6.35
Lung5.35
Lymphnode11.45
Lymphoma_burkitts(Daudi)6.1
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.35
OccipitalLobe4.3
OlfactoryBulb3.8
Ovary3.25
Pancreas3.85
PancreaticIslet5.05
ParietalLobe5.05
Pituitary5.55
Placenta4.85
Pons4.5
PrefrontalCortex5.9
Prostate5.65
Salivarygland4.05
SkeletalMuscle5.9
Skin3.85
SmoothMuscle5.35
Spinalcord5.1
SubthalamicNucleus4.4
SuperiorCervicalGanglion5.45
TemporalLobe4.4
Testis4.15
TestisGermCell3.95
TestisIntersitial4
TestisLeydigCell4.75
TestisSeminiferousTubule4.1
Thalamus4.85
Thymus93.65
Thyroid6.05
Tongue4.6
Tonsil5.8
Trachea4
TrigeminalGanglion5.05
Uterus3.85
UterusCorpus4.25
WholeBlood23.45
Wholebrain3.95
colon4.8
pineal_day5.9
pineal_night5.8
retina5.75
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P169234
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.85 ± 0.96
Basal Forebrain1.39 ± 0.24
Basal Part of Pons1.43 ± 0.39
Cerebellar Cortex1.7 ± 0.78
Cerebellar Nuclei1.86 ± 0.84
Claustrum2.56 ± 0.92
Epithalamus1.38 ± 0.56
Frontal Lobe1.52 ± 0.72
Globus Pallidus2.01 ± 0.64
Hypothalamus1.6 ± 0.51
Insula1.52 ± 0.69
Limbic Lobe1.61 ± 0.82
Mesencephalon1.81 ± 0.79
Myelencephalon1.72 ± 0.69
Occipital Lobe1.54 ± 0.74
Parietal Lobe1.66 ± 0.87
Pontine Tegmentum1.7 ± 0.84
Striatum1.87 ± 0.79
Subthalamus1.71 ± 0.62
Temporal Lobe1.58 ± 0.72
Thalamus1.79 ± 0.64
White Matter1.79 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zap70CBCerebellum7.53
8.74
Zap70CTXCerebral cortex17.19
11.14
Zap70HIPHippocampal region13.36
13.27
Zap70HPFHippocampal formation13.79
11.89
Zap70HYHypothalamus8.61
6.41
Zap70LSXLateral septal complex3.68
2.35
Zap70MBMidbrain6.09
5.33
Zap70MYMedulla7.57
7.43
Zap70OLFOlfactory bulb19.63
12.97
Zap70PPons7.08
6.49
Zap70PALPallidum7.06
5.44
Zap70RHPRetrohippocampal region14.85
10.05
Zap70sAMYStriatum-like amygdalar nuclei10.14
7.14
Zap70STRStriatum7.01
4.8
Zap70STRdStriatum dorsal region6.4
4.56
Zap70STRvStriatum ventral region8.28
4.9
Zap70THThalamus19.27
15.8
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00032292 14 76 89 AHCGPAELCEFYSR Peptide Atlas
ZAP70_HUMAN_2 16 2 17 PDPAAHLPFFYGSISR PRIDE
ZAP70_HUMAN_25 12 25 36 LAGMADGLFLLR PRIDE
ZAP70_HUMAN_284 15 284 298 IDTLNSDGYTPEPAR PRIDE
ZAP70_HUMAN_386 15 386 400 EAQIMHQLDNPYIVR PRIDE
ZAP70_HUMAN_400 24 400 423 LIGVCQAEALMLVMEMAGGGPLHK PRIDE
ZAP70_HUMAN_429 21 429 449 REEIPVSNVAELLHQVSMGMK PRIDE
ZAP70_HUMAN_430 20 430 449 EEIPVSNVAELLHQVSMGMK PRIDE
ZAP70_HUMAN_485 12 485 496 ALGADDSYYTAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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