AutismKB 2.0

Annotation Detail for ZNF22


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Basic Information Top
Gene Symbol:ZNF22 ( HKR-T1,KOX15,ZNF422,Zfp422 )
Gene Full Name: zinc finger protein 22 (KOX 15)
Band: 10q11.21
Quick LinksEntrez ID:7570; OMIM: 194529; Uniprot ID:ZNF22_HUMAN; ENSEMBL ID: ENSG00000165512; HGNC ID: 13012
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus30 / 56401253
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult78 / 193912140
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult22 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia10 / 95842104
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia1 / 9725010
normal146 / 336030743
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal55 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood4 / 12347832
bone5 / 7165569
bone marrow3 / 4880161
brain23 / 110098920
cervix0 / 481710 
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye9 / 21105442
heart9 / 89626100
intestine6 / 23447225
kidney11 / 21177751
larynx1 / 2414541
liver6 / 20774328
lung11 / 33697432
lymph1 / 4427022
lymph node13 / 91610141
mammary gland12 / 15327178
mouth0 / 670520 
muscle6 / 10771555
nerve1 / 1576863
ovary2 / 10205119
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx6 / 41328145
pituitary gland1 / 1658560
placenta17 / 28082560
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach3 / 9661931
testis9 / 33044227
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone0 / 716550 
bone marrow2 / 4880140
brain11 / 11009899
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye1 / 2110544
heart3 / 8962633
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung2 / 3369745
lymph1 / 4427022
lymph node2 / 9161021
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate3 / 18934515
salivary gland1 / 2015549
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis10 / 33044230
thymus4 / 8113149
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218005_at
Cell line Expression level Expression bar
721_B_lymphoblasts300.6
Adipocyte5.65
AdrenalCortex5.45
Adrenalgland4.45
Amygdala5.85
Appendix5.65
AtrioventricularNode4.15
BDCA4+_DentriticCells232.05
Bonemarrow5.25
BronchialEpithelialCells5.85
CD105+_Endothelial153.15
CD14+_Monocytes48.6
CD19+_BCells(neg._sel.)374.6
CD33+_Myeloid52.25
CD34+649.35
CD4+_Tcells53.05
CD56+_NKCells368.7
CD71+_EarlyErythroid6.65
CD8+_Tcells82.35
CardiacMyocytes5.7
Caudatenucleus4.85
Cerebellum4.25
CerebellumPeduncles5.7
CiliaryGanglion3.85
CingulateCortex5.8
Colorectaladenocarcinoma6.8
DorsalRootGanglion4.15
FetalThyroid8.5
Fetalbrain29.65
Fetalliver20.9
Fetallung45.15
GlobusPallidus4.15
Heart5.95
Hypothalamus11.3
Kidney4.3
Leukemia_chronicMyelogenousK-5628.25
Leukemia_promyelocytic-HL-6086.5
Leukemialymphoblastic(MOLT-4)296.35
Liver7.1
Lung5.7
Lymphnode21
Lymphoma_burkitts(Daudi)15.65
Lymphoma_burkitts(Raji)22.45
MedullaOblongata6
OccipitalLobe5.15
OlfactoryBulb6.9
Ovary3.6
Pancreas19.45
PancreaticIslet46.65
ParietalLobe5.65
Pituitary11.15
Placenta14.05
Pons5.2
PrefrontalCortex7.45
Prostate7.4
Salivarygland9.1
SkeletalMuscle6.2
Skin4.2
SmoothMuscle9.7
Spinalcord6.05
SubthalamicNucleus4.85
SuperiorCervicalGanglion6.3
TemporalLobe4.7
Testis4.65
TestisGermCell7.15
TestisIntersitial4.75
TestisLeydigCell4.6
TestisSeminiferousTubule4.8
Thalamus5.05
Thymus26.75
Thyroid23.3
Tongue5
Tonsil9.2
Trachea4.8
TrigeminalGanglion5.25
Uterus26.85
UterusCorpus5
WholeBlood26.65
Wholebrain8.15
colon6.95
pineal_day16
pineal_night17.7
retina9.175
small_intestine8.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P384512
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.41 ± 0.39
Basal Forebrain4.38 ± 0.31
Basal Part of Pons3.8 ± 0.37
Cerebellar Cortex4.38 ± 0.36
Cerebellar Nuclei4.23 ± 0.65
Claustrum3.89 ± 0.67
Epithalamus4.54 ± 0.38
Frontal Lobe4.07 ± 0.5
Globus Pallidus4.74 ± 0.41
Hypothalamus4.31 ± 0.43
Insula4.25 ± 0.37
Limbic Lobe4.08 ± 0.44
Mesencephalon4.29 ± 0.53
Myelencephalon4.23 ± 0.56
Occipital Lobe4.3 ± 0.47
Parietal Lobe4.19 ± 0.51
Pontine Tegmentum4.26 ± 0.59
Striatum4.25 ± 0.48
Subthalamus4.45 ± 0.69
Temporal Lobe4.15 ± 0.46
Thalamus4.24 ± 0.47
White Matter5.12 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp422CBCerebellum0.9
1.46
Zfp422CTXCerebral cortex5.67
4.56
Zfp422HIPHippocampal region1.93
1.93
Zfp422HPFHippocampal formation1.43
1.4
Zfp422HYHypothalamus0.08
0.06
Zfp422LSXLateral septal complex0.72
1.59
Zfp422MBMidbrain0.75
1.23
Zfp422MYMedulla0.61
0.8
Zfp422OLFOlfactory bulb2.8
2.98
Zfp422PPons0.93
1.85
Zfp422PALPallidum1.28
1.19
Zfp422RHPRetrohippocampal region0.48
0.55
Zfp422sAMYStriatum-like amygdalar nuclei3.43
2.38
Zfp422STRStriatum1.34
1.59
Zfp422STRdStriatum dorsal region1.15
1.84
Zfp422STRvStriatum ventral region0.98
0.67
Zfp422THThalamus0.6
0.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000978 13 147 159 CFSQSSHLIQHQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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