AutismKB 2.0

Annotation Detail for ZNF74


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Basic Information Top
Gene Symbol:ZNF74 ( Cos52,ZNF520,Zfp520 )
Gene Full Name: zinc finger protein 74
Band: 22q11.21
Quick LinksEntrez ID:7625; OMIM: 194548; Uniprot ID:ZNF74_HUMAN; ENSEMBL ID: ENSG00000185252; HGNC ID: 13144
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst7 / 62319112
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult26 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor10 / 26384537
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor6 / 6895987
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal90 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow1 / 4880120
brain62 / 110098956
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine2 / 2344728
kidney7 / 21177733
larynx0 / 241450 
liver1 / 2077434
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth4 / 6705259
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis9 / 33044227
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205881_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.8
Adipocyte6.1
AdrenalCortex6.8
Adrenalgland5.15
Amygdala6.35
Appendix10
AtrioventricularNode7.85
BDCA4+_DentriticCells6.9
Bonemarrow6.05
BronchialEpithelialCells6.05
CD105+_Endothelial6.35
CD14+_Monocytes6.6
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid8
CD34+11.75
CD4+_Tcells6.85
CD56+_NKCells8.25
CD71+_EarlyErythroid5.85
CD8+_Tcells6.1
CardiacMyocytes8
Caudatenucleus5.55
Cerebellum4.95
CerebellumPeduncles7.7
CiliaryGanglion4.9
CingulateCortex6.3
Colorectaladenocarcinoma6.2
DorsalRootGanglion8.75
FetalThyroid6.05
Fetalbrain6.25
Fetalliver5.05
Fetallung4.6
GlobusPallidus4.6
Heart7.9
Hypothalamus6.75
Kidney5.15
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.4
Leukemialymphoblastic(MOLT-4)5.2
Liver8.15
Lung6.9
Lymphnode5.35
Lymphoma_burkitts(Daudi)7.85
Lymphoma_burkitts(Raji)9
MedullaOblongata5.7
OccipitalLobe5.55
OlfactoryBulb4.85
Ovary4.2
Pancreas4.95
PancreaticIslet6.6
ParietalLobe7.3
Pituitary7.25
Placenta6
Pons5.85
PrefrontalCortex7.75
Prostate7.25
Salivarygland4.95
SkeletalMuscle7.25
Skin5.1
SmoothMuscle7
Spinalcord6.5
SubthalamicNucleus8.2
SuperiorCervicalGanglion7.15
TemporalLobe5.8
Testis4.85
TestisGermCell4.9
TestisIntersitial5.2
TestisLeydigCell6.1
TestisSeminiferousTubule5.35
Thalamus6.3
Thymus4.8
Thyroid7.7
Tongue6.15
Tonsil6
Trachea5.2
TrigeminalGanglion8.5
Uterus5.05
UterusCorpus6.8
WholeBlood6.45
Wholebrain5.25
colon5.8
pineal_day7.88
pineal_night7.66
retina7.55
small_intestine5.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5444_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.31 ± 0.95
Basal Forebrain2.14 ± 0.48
Basal Part of Pons1.83 ± 0.37
Cerebellar Cortex2.44 ± 0.47
Cerebellar Nuclei2.24 ± 0.68
Claustrum2.7 ± 0.71
Epithalamus1.97 ± 0.58
Frontal Lobe2.02 ± 0.66
Globus Pallidus1.45 ± 0.66
Hypothalamus1.84 ± 0.62
Insula1.92 ± 0.87
Limbic Lobe2 ± 0.6
Mesencephalon2.15 ± 0.68
Myelencephalon2.01 ± 0.64
Occipital Lobe2.21 ± 0.73
Parietal Lobe1.98 ± 0.67
Pontine Tegmentum2.14 ± 0.69
Striatum1.83 ± 0.54
Subthalamus2.23 ± 0.32
Temporal Lobe2.08 ± 0.66
Thalamus1.99 ± 0.6
White Matter2.16 ± 1.02
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018